KR870700071A - 비타민 d 유도체 및 이의 제조방법 - Google Patents

비타민 d 유도체 및 이의 제조방법

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Publication number
KR870700071A
KR870700071A KR1019860700644A KR860700644A KR870700071A KR 870700071 A KR870700071 A KR 870700071A KR 1019860700644 A KR1019860700644 A KR 1019860700644A KR 860700644 A KR860700644 A KR 860700644A KR 870700071 A KR870700071 A KR 870700071A
Authority
KR
South Korea
Prior art keywords
compound
hydrogen
carbon
benzoyl
acyl
Prior art date
Application number
KR1019860700644A
Other languages
English (en)
Other versions
KR910004337B1 (ko
Inventor
드루카 헥터 에프
이게까와 노부오
다나까 요꼬
슈노스 하인리히 케이
오스트렘 보울라
Original Assignee
존 알, 피케
위스콘신 알럼니 리서치 화운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/739,332 external-priority patent/US4717721A/en
Priority claimed from PCT/US1986/000009 external-priority patent/WO1986004169A1/en
Application filed by 존 알, 피케, 위스콘신 알럼니 리서치 화운데이션 filed Critical 존 알, 피케
Publication of KR870700071A publication Critical patent/KR870700071A/ko
Application granted granted Critical
Publication of KR910004337B1 publication Critical patent/KR910004337B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음.

Description

비타민 D 유도체 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 일반식의 화합물.
    상기식에서, R1, R2및 R3는 수소, 탄소수1 내지 약 4의 아실 및 벤조일로 이루어진 그룹중에 서선택하고; R4및 R5는 각기 수소이거나, 함께 탄소―탄소 이중결합을 형성한다.
  2. 제1항에 있어서, R1, R2및 R3가 수소이고, R4및 R5가 수소인 화합물.
  3. 제2항에 있어서, 결정형태인 화합물.
  4. 제2항에 있어서, 약제학적으로 허용되는 부평제와 혼합된 형태의 화합물.
  5. 제1항에 있어서, R1, R2및 R3가 수소이고, R4및 R5가 함께 탄소―탄소 이중결합을 형성하는 화합물.
  6. 제5항에 있어서, 결정형태인 화합물.
  7. 제4항에 있어서, 약제학적으로 허용되는 부평제와 혼합된 형태의 화합물.
  8. 제4항에 있어서, Δ22결합이 E 배위인 화합물.
  9. 다음 일반식의 화합물.
    상기식에서, R은 수소, 탄소수 1 내지 약 4의 아실, 벤조일 및 메톡시메틸로 이루어진 그룹중에서 선택한다.
  10. 다음 일반식의 화합물.
    상기식에서, R1, R2및 R3는 수소, 탄소수 1 내지 약 4의 아실 및 벤조일로 이루어진 그룹중에서 선택하고; R4및 R5는 수소이거나, 함께 탄소―탄소 이중결합을 형성한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860700644A 1985-01-17 1986-01-15 비타민 d 유도체 및 이를 함유하는 약제 KR910004337B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69215185A 1985-01-17 1985-01-17
US06/739,332 US4717721A (en) 1985-05-30 1985-05-30 Sidechain homo-vitamin D compounds with preferential anti-cancer activity
US739332 1985-05-30
US692151 1985-05-30
PCT/US1986/000009 WO1986004169A1 (en) 1985-01-07 1986-01-06 Printer-tape data link processor

Publications (2)

Publication Number Publication Date
KR870700071A true KR870700071A (ko) 1987-02-28
KR910004337B1 KR910004337B1 (ko) 1991-06-26

Family

ID=27104918

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860700644A KR910004337B1 (ko) 1985-01-17 1986-01-15 비타민 d 유도체 및 이를 함유하는 약제

Country Status (7)

Country Link
EP (1) EP0211863B1 (ko)
JP (3) JPH0678354B2 (ko)
KR (1) KR910004337B1 (ko)
AU (1) AU594662B2 (ko)
DE (1) DE3687377T2 (ko)
DK (3) DK157007C (ko)
WO (1) WO1986004333A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
JPH0699454B2 (ja) * 1988-04-29 1994-12-07 ウィスコンシン・アルムナイ・リサーチ・ファウンデイション １α―ヒドロキシビタミンＤ同族体
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4226770A (en) * 1978-02-10 1980-10-07 Kaiser Emil T Synthesis of steroids
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
AU568549B2 (en) * 1983-05-09 1988-01-07 Wisconsin Alumni Research Foundation Process for the preparation of 1a, 25-dihydroxylated vitamin d2 and related compounds
CH665835A5 (de) * 1984-01-30 1988-06-15 Wisconsin Alumni Res Found 1alpha,25-dihydroxy-22z-dehydrovitamin d-verbindung.

Also Published As

Publication number Publication date
EP0211863A1 (en) 1987-03-04
DK56490A (da) 1990-03-05
DK56490D0 (da) 1990-03-05
AU5359786A (en) 1986-08-13
DK157007C (da) 1990-03-19
EP0211863B1 (en) 1992-12-30
JPH0635474B2 (ja) 1994-05-11
JPH05132499A (ja) 1993-05-28
DK159273C (da) 1991-02-18
DK162394B (da) 1991-10-21
DK443186D0 (da) 1986-09-16
JPH0649092A (ja) 1994-02-22
DE3687377D1 (de) 1993-02-11
AU594662B2 (en) 1990-03-15
JPH0678354B2 (ja) 1994-10-05
EP0211863A4 (en) 1987-03-16
KR910004337B1 (ko) 1991-06-26
JPH06128160A (ja) 1994-05-10
DK162394C (da) 1992-03-09
WO1986004333A1 (en) 1986-07-31
DK159273B (da) 1990-09-24
DK157007B (da) 1989-10-30
DK443186A (da) 1986-09-16
DK35889D0 (da) 1989-01-27
DE3687377T2 (de) 1993-04-29
JPH0737391B2 (ja) 1995-04-26
DK35889A (da) 1989-01-27

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