KR870001235A - 11-메틸렌-에스트르-15-엔 스테로이드의 제조 방법 - Google Patents

11-메틸렌-에스트르-15-엔 스테로이드의 제조 방법 Download PDF

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Publication number
KR870001235A
KR870001235A KR1019860005965A KR860005965A KR870001235A KR 870001235 A KR870001235 A KR 870001235A KR 1019860005965 A KR1019860005965 A KR 1019860005965A KR 860005965 A KR860005965 A KR 860005965A KR 870001235 A KR870001235 A KR 870001235A
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KR
South Korea
Prior art keywords
compound
methylene
estra
ethynyl
estr
Prior art date
Application number
KR1019860005965A
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English (en)
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KR930011284B1 (ko
Inventor
엥겔베르트 빌름 베르깅크 독토르
엥겔베르트 빌름 베르 깅크 독토르
Original Assignee
악조 엔.브이.
아. 게. 유트. 베르메렌, 아. 데. 도우마
악조 엔. 브이.
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Application filed by 악조 엔.브이., 아. 게. 유트. 베르메렌, 아. 데. 도우마, 악조 엔. 브이. filed Critical 악조 엔.브이.
Publication of KR870001235A publication Critical patent/KR870001235A/ko
Application granted granted Critical
Publication of KR930011284B1 publication Critical patent/KR930011284B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals

Abstract

내용 없음.

Description

11-메틸렌-에스트르-15-엔 스테로이드의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기식(I)로 나타나는 11-메틸렌-스테로이드 화합물.
    상기식에서, R1=H 또는 1-18 탄소수의 아실, R2=에티닐, 비닐, 클로로에티닐, 알릴 또는 프로피닐, R3=0 또는 H2이다.
  2. 제1항에 있어서, R1=H인 화합물.
  3. 제1항 내지 2항중 어느 한항에 있어서, R2=에티닐인 화합물.
  4. 제1항 내지 3항중 어느 한항에 있어서, R3=O인 화합물.
  5. 11-메틸렌-17α-에티닐-17β-히드록시-에스트라-4,15-디엔-3-온 화합물.
  6. 제1항 내지 5항중 어느 한항에 있어서, 11-메틸렌-에스트라-4-엔-17-온 화합물을 출발물질로 하여 여기에 15α-히드록시기를 도입함으로서 산출된 생성물을 탈수화시켜 C-15와 C-16사이에 이중결합을 형성한뒤 마지막으로 3 및/또는 17위치에 치환체를 도입시켜 11-메틸렌-에스트라-4-엔-17-온 화합물을 제조하는 방법.
  7. 제1항 내지 5항에 따른 하나 또는 그 이상의 스테로이드를 함유하는 약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005965A 1985-07-24 1986-07-23 11-메틸렌-스테로이드 화합물의 제조방법 KR930011284B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL85-02115 1985-07-24
NL8502115 1985-07-24
NL8502115 1985-07-24

Publications (2)

Publication Number Publication Date
KR870001235A true KR870001235A (ko) 1987-03-12
KR930011284B1 KR930011284B1 (ko) 1993-11-29

Family

ID=19846354

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860005965A KR930011284B1 (ko) 1985-07-24 1986-07-23 11-메틸렌-스테로이드 화합물의 제조방법

Country Status (14)

Country Link
EP (1) EP0210678B1 (ko)
JP (1) JPH089633B2 (ko)
KR (1) KR930011284B1 (ko)
AU (1) AU589429B2 (ko)
BR (1) BR1100900A (ko)
CA (1) CA1314869C (ko)
DE (1) DE3665720D1 (ko)
DK (1) DK352586A (ko)
ES (1) ES8802233A1 (ko)
FI (1) FI85709C (ko)
GR (1) GR861633B (ko)
IE (1) IE58562B1 (ko)
PT (1) PT82928B (ko)
ZA (1) ZA864925B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5890232A (en) * 1997-11-25 1999-04-06 Park; Nam-Tae Helmet with an air cushion buffer

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5881909A (en) * 1993-02-01 1999-03-16 Maytag Corporation Plastic washing machine basket
EP0897927A1 (en) * 1997-08-11 1999-02-24 Akzo Nobel N.V. Novel crystalline form of the progestagen - (17alpha) 17-hydroxy-11-methylene-19-nor-pregna-4,15-dien-2 0-yn-3-one(Org 30659)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927046A (en) * 1972-12-09 1975-12-16 Akzona Inc Novel 11,11-alkylidene steroids
DE2943778A1 (de) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
DE3042529A1 (de) * 1980-11-07 1982-06-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen 11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3337179A1 (de) * 1983-10-10 1985-05-23 Schering AG, 1000 Berlin und 4709 Bergkamen Estran- und androstan-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende praeparate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5890232A (en) * 1997-11-25 1999-04-06 Park; Nam-Tae Helmet with an air cushion buffer

Also Published As

Publication number Publication date
GR861633B (en) 1986-10-15
IE861677L (en) 1987-01-24
ES556807A0 (es) 1988-04-16
FI862970A (fi) 1987-01-25
ZA864925B (en) 1987-02-25
EP0210678A1 (en) 1987-02-04
AU589429B2 (en) 1989-10-12
EP0210678B1 (en) 1989-09-20
FI862970A0 (fi) 1986-07-17
JPH089633B2 (ja) 1996-01-31
AU6016286A (en) 1987-01-29
ES8802233A1 (es) 1988-04-16
BR1100900A (pt) 1999-12-07
DK352586D0 (da) 1986-07-24
KR930011284B1 (ko) 1993-11-29
JPS6230799A (ja) 1987-02-09
PT82928B (pt) 1988-05-27
DE3665720D1 (en) 1989-10-26
IE58562B1 (en) 1993-10-06
FI85709C (fi) 1992-05-25
PT82928A (en) 1986-08-01
DK352586A (da) 1987-01-25
FI85709B (fi) 1992-02-14
CA1314869C (en) 1993-03-23

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