KR850004391A - 비-수성 아이버멕틴 제형 - Google Patents
비-수성 아이버멕틴 제형 Download PDFInfo
- Publication number
- KR850004391A KR850004391A KR1019840008224A KR840008224A KR850004391A KR 850004391 A KR850004391 A KR 850004391A KR 1019840008224 A KR1019840008224 A KR 1019840008224A KR 840008224 A KR840008224 A KR 840008224A KR 850004391 A KR850004391 A KR 850004391A
- Authority
- KR
- South Korea
- Prior art keywords
- dissolved
- propylene glycol
- mixture
- ivermectin
- mentioned
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 18
- 238000009472 formulation Methods 0.000 title claims 10
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title claims 8
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 title claims 8
- 229960002418 ivermectin Drugs 0.000 title claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000005660 Abamectin Substances 0.000 claims 5
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 3
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000003071 parasitic effect Effects 0.000 claims 2
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940074076 glycerol formal Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 프로필렌 글리콜과 글리세롤 포름알 또는 물과의 혼합물에 용해된 애버멕틴 또는 밀베마이신으로 이루어진 내부 및 외부 구충제 비경구 제형.
- 제1항에 있어서, 언급된 애버멕틴 또는 밀베마이신 화합물이 아이버멕틴인 제형.
- 제2항에 있어서, 언급된 아이버멕틴이 글리세를 포름알과 프로필렌 글리콜과의 혼합물에 용해된 제형.
- 제3항에 있어서, 언급된 아이버멕틴이 0.1 내지 20%W/V로 존재하며, 글리세를 포름알과 프로필렌 글리콜과의 10:90 내지 90:10V/V비의 혼합물에 용해된 재형.
- 제4항에 있어서, 언급된 아이버멕틴이 약 1%W/V로 존재하고, 약 40:60의 비로 용매에 용해된 제형.
- 제2항에 있어서, 언급된 아이버멕틴이 프로필렌글리콜과 물과의 혼합물에 용해된 제형.
- 제6항에 있어서, 언급된 아이버멕틴이 0.1 내지 20%W/V로 존재하고, 프로필렌 글리콜과 물과의 95:5 내지 80:20V/V비의 혼합물에 용해된 제형.
- 제7항에 있어서, 언급된 아이버멕틴이 약 1%W/V로 존재하고, 약 90:10의 비로 용매에 용해된 제형.
- 애버멕틴을 충분량의 글리세를 포름알, 프로필렌 글리콜 또는 이들의 혼합물에 용해시키고, 용매 농도를 목적치로 조절하는 것으로 이루어짐을 특징으로 하는, 프로필렌 글리콜과 글리세를 포름알 또는 물과의 혼합물에 용해된 애버멕틴 또는 밀베마이신으로 이루어진 내부 및 외부구충제 비경구 제형의 제조방법.
- 애버멕틴을 충분량의 프로필렌 글리콜에 용해시키고, 필요량의 물을 첨가시킨 다음, 프로필렌 글리콜을 사용하여 농도를 목적치로 조절하는 것으로 이루어짐을 특징으로 하는, 프로필렌 글리콜과 글리세를 포름알 또는 물과의 혼합물에 용해된 애버멕틴 또는 밀베마이신으로 이루어진 내부 및 외부구충제 비경구 제형의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56414083A | 1983-12-22 | 1983-12-22 | |
US564,140 | 1983-12-22 | ||
US564140 | 2000-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850004391A true KR850004391A (ko) | 1985-07-15 |
KR880002366B1 KR880002366B1 (ko) | 1988-11-03 |
Family
ID=24253315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840008224A KR880002366B1 (ko) | 1983-12-22 | 1984-12-21 | 비-수성 아이버멕틴 제제 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0146414B1 (ko) |
JP (1) | JPH0623100B2 (ko) |
KR (1) | KR880002366B1 (ko) |
AT (1) | ATE47522T1 (ko) |
AU (1) | AU560864B2 (ko) |
CA (1) | CA1267844A (ko) |
DE (1) | DE3480263D1 (ko) |
DK (1) | DK164772C (ko) |
ES (1) | ES8608888A1 (ko) |
GR (1) | GR81244B (ko) |
HK (1) | HK5091A (ko) |
IE (1) | IE57681B1 (ko) |
IL (1) | IL73800A (ko) |
NZ (1) | NZ210505A (ko) |
PT (1) | PT79656B (ko) |
SG (1) | SG97890G (ko) |
ZA (1) | ZA849841B (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2058244T3 (es) * | 1987-01-23 | 1994-11-01 | Pfizer | Procedimiento para produccion de avermectinas y cultivos para el mismo. |
US5075307A (en) * | 1987-07-28 | 1991-12-24 | Merck & Co., Inc. | Paraherquamide and dihydroparaherquamide as antihelminthic agents |
GB8803836D0 (en) * | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
US6001822A (en) * | 1989-04-11 | 1999-12-14 | Pfizer Inc. | Antiparasitic formulations |
US5169846A (en) * | 1989-10-12 | 1992-12-08 | Crooks Michael J | Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators |
NZ335166A (en) | 1999-04-14 | 2001-11-30 | Ashmont Holdings Ltd | Anthelmintic composition containing triclabendazole in at least one solvent |
GB2275193A (en) * | 1993-02-17 | 1994-08-24 | Merck & Co Inc | Formulations for the topical delivery of avermectins |
PL174488B1 (pl) * | 1993-05-10 | 1998-08-31 | Merck & Co Inc | Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt |
US5602107A (en) * | 1993-05-10 | 1997-02-11 | Merck & Co., Inc. | Pour-on formulations consisting of gylcols, glycerides and avermectin compounds |
SI9420028A (en) * | 1993-05-10 | 1996-06-30 | Merck & Co Inc | Pour-on medical formulations containing avermectin compound as a medical active agent, polymeric material, glycols and glycerides |
DE19613972A1 (de) * | 1996-04-09 | 1997-10-16 | Bayer Ag | Injektionsformulierungen von Avermectinen und Milbemycinen auf Basis von Rizinusöl |
DE19638045A1 (de) * | 1996-09-18 | 1998-03-19 | Bayer Ag | Injektionsformulierungen von Avermectinen und Milbemycinen |
ZA981925B (en) * | 1997-03-21 | 1998-10-23 | Biogenesis S A | A long acting injectable parasiticidal composition and the process for its preparation |
UY25089A1 (es) * | 1997-07-10 | 2000-08-21 | Hoechst Roussel Vet Gmbh | Vacunas no acuosas |
GB9816132D0 (en) * | 1998-07-24 | 1998-09-23 | Norbrook Lab Ltd | Non-aqueous anthelmintic composition |
AU7463000A (en) * | 1999-09-22 | 2001-04-24 | Ashmont Holdings Limited | Sheep pour-on |
JP2001253824A (ja) * | 2000-03-14 | 2001-09-18 | Mitsukazu Matsumoto | 局所注射用処方剤 |
GR1003969B (el) * | 2001-02-05 | 2002-08-14 | U��-Pharma ����� ������ ������������ ���������� ���� | Σταθερα φαρμακευτικα διαλυματα νιμεσουλιδης. |
US20050009762A1 (en) | 2003-06-06 | 2005-01-13 | Strobel Michael Albert | Application of water and organic solvent soluble ivermectin for topical and oral use |
US6627613B2 (en) | 2001-07-23 | 2003-09-30 | Michael A. Strobel | Application of water and organic solvent soluble ivermectin for topical and oral use |
GB2386066A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species |
UY27412A1 (es) * | 2002-08-12 | 2003-06-30 | Carlson Internat Inc | Un nuevo producto para el combate de garrapatas y el proceso para la prepaacinn. |
GB0316377D0 (en) | 2003-07-12 | 2003-08-13 | Norbrook Lab Ltd | Parasiticidal composition |
JP4886214B2 (ja) * | 2005-05-24 | 2012-02-29 | 日本パワーファスニング株式会社 | 石膏ボード締結用の2条式木ねじ |
PT2331068T (pt) | 2008-10-08 | 2017-03-13 | Zoetis Services Llc | Composições anti-helmínticas de benzimidazol |
JP5607114B2 (ja) | 2012-06-26 | 2014-10-15 | 株式会社トープラ | タッピンねじ |
EP4337015A1 (en) | 2021-05-14 | 2024-03-20 | Syngenta Crop Protection AG | Insect, acarina and nematode pest control |
WO2022268815A1 (en) | 2021-06-24 | 2022-12-29 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4144352A (en) * | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
US4130651A (en) * | 1978-03-31 | 1978-12-19 | American Cyanamid Company | Butamisole injectable formulations having improved margin of safety in dogs |
OA06863A (fr) * | 1980-08-04 | 1983-02-28 | Merck & Co Inc | Solubilisation de l'invermectine dans l'eau. |
US4430329A (en) * | 1982-05-17 | 1984-02-07 | Merck & Co., Inc. | Synergistic treatment of adult canine heartworm with thiacetarsamide and ivermectin |
-
1984
- 1984-12-10 NZ NZ210505A patent/NZ210505A/xx unknown
- 1984-12-11 PT PT79656A patent/PT79656B/pt unknown
- 1984-12-11 IL IL73800A patent/IL73800A/xx not_active IP Right Cessation
- 1984-12-12 GR GR81244A patent/GR81244B/el unknown
- 1984-12-14 IE IE3221/84A patent/IE57681B1/en not_active IP Right Cessation
- 1984-12-14 CA CA000470213A patent/CA1267844A/en not_active Expired - Lifetime
- 1984-12-18 ES ES538750A patent/ES8608888A1/es not_active Expired
- 1984-12-18 ZA ZA849841A patent/ZA849841B/xx unknown
- 1984-12-20 JP JP59267598A patent/JPH0623100B2/ja not_active Expired - Lifetime
- 1984-12-21 DK DK619784A patent/DK164772C/da active
- 1984-12-21 KR KR1019840008224A patent/KR880002366B1/ko not_active IP Right Cessation
- 1984-12-21 DE DE8484309044T patent/DE3480263D1/de not_active Expired
- 1984-12-21 AU AU37024/84A patent/AU560864B2/en not_active Expired
- 1984-12-21 EP EP84309044A patent/EP0146414B1/en not_active Expired
- 1984-12-21 AT AT84309044T patent/ATE47522T1/de not_active IP Right Cessation
-
1990
- 1990-12-10 SG SG978/90A patent/SG97890G/en unknown
-
1991
- 1991-01-10 HK HK50/91A patent/HK5091A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ210505A (en) | 1988-06-30 |
JPS60169415A (ja) | 1985-09-02 |
AU560864B2 (en) | 1987-04-16 |
JPH0623100B2 (ja) | 1994-03-30 |
DK164772C (da) | 1993-01-04 |
HK5091A (en) | 1991-01-18 |
SG97890G (en) | 1991-02-14 |
GR81244B (en) | 1985-04-16 |
ES538750A0 (es) | 1986-07-16 |
ATE47522T1 (de) | 1989-11-15 |
PT79656B (en) | 1987-01-16 |
IL73800A0 (en) | 1985-03-31 |
PT79656A (en) | 1985-01-01 |
AU3702484A (en) | 1985-07-04 |
EP0146414A2 (en) | 1985-06-26 |
IE843221L (en) | 1985-06-22 |
CA1267844A (en) | 1990-04-17 |
DK164772B (da) | 1992-08-17 |
ZA849841B (en) | 1986-07-30 |
EP0146414A3 (en) | 1986-12-10 |
KR880002366B1 (ko) | 1988-11-03 |
ES8608888A1 (es) | 1986-07-16 |
IL73800A (en) | 1987-11-30 |
EP0146414B1 (en) | 1989-10-25 |
DK619784A (da) | 1985-06-23 |
IE57681B1 (en) | 1993-02-24 |
DK619784D0 (da) | 1984-12-21 |
DE3480263D1 (en) | 1989-11-30 |
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