ES8802233A1 - Un procedimiento para la preparacion de nuevos 11-metileno-esteroides. - Google Patents

Un procedimiento para la preparacion de nuevos 11-metileno-esteroides.

Info

Publication number
ES8802233A1
ES8802233A1 ES556807A ES556807A ES8802233A1 ES 8802233 A1 ES8802233 A1 ES 8802233A1 ES 556807 A ES556807 A ES 556807A ES 556807 A ES556807 A ES 556807A ES 8802233 A1 ES8802233 A1 ES 8802233A1
Authority
ES
Spain
Prior art keywords
oestr
enes
methylene
novel
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556807A
Other languages
English (en)
Other versions
ES556807A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES8802233A1 publication Critical patent/ES8802233A1/es
Publication of ES556807A0 publication Critical patent/ES556807A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LOS METILENO-ESTEROIDES (I), DONDE NO EXCLUSIVAMENTE, R1 ES ACILO C1-18, R2 VINILO O CLOROETINILO Y R3 OXIGENO O DOS HIDROGENOS; SE OBTIENEN: A) INTRODUCIENDO UN GRUPO 15 ALFA HIDROXI POR MEDIO DE HONGOS DEL GENERO PENICILLIUM Y OTROS, EN EL 11-METILEN-ESTRA-4-EN-17-ONA; B) PROTEGIENDO EL GRUPO 3-OXO EN FORMA DE ACETAL; C) DESHIDRATANDO PARA FORMAR UN DOBLE ENLACE C-15 Y C-16, PREVIA CONVERSION DEL GRUPO 15 ALFA-HIDROXI EN ACILATO; D) INTRODUCIENDO R2 MEDIANTE ALQUILACION DEL COMPUESTO 17-OXO CON UN CON COMPUESTO ORGANOMETALICO ETINILICO; E) ESCINDIENDO EL GRUPO 3-ACETAL CON UN ACIDO PARA DAR UN COMPUESTO 3-OXO; Y FINALMENTE F) ESTERIFICANDO SI ESTA PRESENTE Y SI SE DESEA, EL GRUPO 17 BETA HIDROXILO. POR SI SOLOS O EN COMBINACION CON UN ESTROGENO SON ANTICONCEPTIVOS.
ES556807A 1985-07-24 1986-06-25 Un procedimiento para la preparacion de nuevos 11-metileno-esteroides. Expired ES8802233A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8502115 1985-07-24

Publications (2)

Publication Number Publication Date
ES8802233A1 true ES8802233A1 (es) 1988-04-16
ES556807A0 ES556807A0 (es) 1988-04-16

Family

ID=19846354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556807A Expired ES8802233A1 (es) 1985-07-24 1986-06-25 Un procedimiento para la preparacion de nuevos 11-metileno-esteroides.

Country Status (14)

Country Link
EP (1) EP0210678B1 (es)
JP (1) JPH089633B2 (es)
KR (1) KR930011284B1 (es)
AU (1) AU589429B2 (es)
BR (1) BR1100900A (es)
CA (1) CA1314869C (es)
DE (1) DE3665720D1 (es)
DK (1) DK352586A (es)
ES (1) ES8802233A1 (es)
FI (1) FI85709C (es)
GR (1) GR861633B (es)
IE (1) IE58562B1 (es)
PT (1) PT82928B (es)
ZA (1) ZA864925B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5881909A (en) * 1993-02-01 1999-03-16 Maytag Corporation Plastic washing machine basket
EP0897927A1 (en) * 1997-08-11 1999-02-24 Akzo Nobel N.V. Novel crystalline form of the progestagen - (17alpha) 17-hydroxy-11-methylene-19-nor-pregna-4,15-dien-2 0-yn-3-one(Org 30659)
US5890232A (en) * 1997-11-25 1999-04-06 Park; Nam-Tae Helmet with an air cushion buffer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927046A (en) * 1972-12-09 1975-12-16 Akzona Inc Novel 11,11-alkylidene steroids
DE2943778A1 (de) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
DE3042529A1 (de) * 1980-11-07 1982-06-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen 11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3337179A1 (de) * 1983-10-10 1985-05-23 Schering AG, 1000 Berlin und 4709 Bergkamen Estran- und androstan-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende praeparate

Also Published As

Publication number Publication date
IE861677L (en) 1987-01-24
AU6016286A (en) 1987-01-29
KR930011284B1 (ko) 1993-11-29
IE58562B1 (en) 1993-10-06
KR870001235A (ko) 1987-03-12
JPH089633B2 (ja) 1996-01-31
FI85709B (fi) 1992-02-14
GR861633B (en) 1986-10-15
FI85709C (fi) 1992-05-25
FI862970A (fi) 1987-01-25
CA1314869C (en) 1993-03-23
PT82928A (en) 1986-08-01
EP0210678A1 (en) 1987-02-04
FI862970A0 (fi) 1986-07-17
DE3665720D1 (en) 1989-10-26
DK352586A (da) 1987-01-25
ES556807A0 (es) 1988-04-16
AU589429B2 (en) 1989-10-12
PT82928B (pt) 1988-05-27
DK352586D0 (da) 1986-07-24
JPS6230799A (ja) 1987-02-09
BR1100900A (pt) 1999-12-07
EP0210678B1 (en) 1989-09-20
ZA864925B (en) 1987-02-25

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170627