ES2010145A6 - Procedimiento para la obtencion de derivados de la 2-picolilamina. - Google Patents

Procedimiento para la obtencion de derivados de la 2-picolilamina.

Info

Publication number
ES2010145A6
ES2010145A6 ES8900754A ES8900754A ES2010145A6 ES 2010145 A6 ES2010145 A6 ES 2010145A6 ES 8900754 A ES8900754 A ES 8900754A ES 8900754 A ES8900754 A ES 8900754A ES 2010145 A6 ES2010145 A6 ES 2010145A6
Authority
ES
Spain
Prior art keywords
picolylamine
hydrogen
case
derivates
aminocarboniloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8900754A
Other languages
English (en)
Inventor
Javier Bartroli
Manuel Anguita
Elena Carceller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES8900754A priority Critical patent/ES2010145A6/es
Publication of ES2010145A6 publication Critical patent/ES2010145A6/es
Priority to CA002011277A priority patent/CA2011277A1/en
Priority to US07/487,476 priority patent/US5134151A/en
Priority to JP2051594A priority patent/JPH0334968A/ja
Priority to EP19900104051 priority patent/EP0385490A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA 2-PICOLILAMINA. EN LA PRESENTE INVENCION SE DESCRIBE UN PROCEDIMIENTO PARA OBTENER DERIVADOS DE LA 2-PICOLILAMINA DE FORMULA (I) EN DONDE: R1 REPRESENTA UN RADICAL ALQUILICO O FENILALQUILICO; R2 REPRESENTA HIDROGENO, C1-C4, ACILO O C1-C4 ALCOXICARBONILO; R3 O BIEN ES UN PAR DE ELECTRONES, EN CUYO CASO T NO SIGNIFICA NADA Y Q ES 0, O BIEN ES HIDROGENO O C1-C4-ALQUILO EN CUYO CASO T ES (+) Y Q=1; Z ES OXIGENO O UN GRUPO AMINOCARBONILOXI; X ES O O S; M Y N VALEN 2-6; P VALE 0-4; A- ES UN ANION FARMACEUTICAMENTE ACEPTABLE. DICHOS COMPUESTOS SON ANTAGONISTAS DEL PAF Y, POR LO TANTO, UTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES EN LAS QUE DICHA SUSTANCIA SE HALLA IMPLICADA. EL PROCEDIMIENTO, MOSTRADO EN EL ESQUEMA ADJUNTO, CONSISTE EN HACER REACCIONAR EL ALCOHOL III CON UN REACTIVO DEL TIPO FOSGENO V, SIENDO X=CL Y Z=OPH, EN PRESENCIA DE UN DISOLVENTE Y UNA BASE CAPTADORA, DE PROTONES, A TEMPERATURA ENTRE 0 Y 50GC, DURANTE UN TIEMPO ENTRE 30 MINUTOS Y 24 H. EL PRODUCTO IV OBTENIDO SE HACE REACCIONAR CON 2-(AMINOMETIL) PIRIDINA EN PRESENCIA DE UN DISOLVENTE Y EN LAS MISMAS CONDICIONES YA CITADAS, OBTENIENDOSE IA, EL CUAL PUEDE HACERSE REACCIONAR CON UN COMPUESTO DE FORMULA R2-X PARA OBTENER IB, A TEMPERATURA ENTRE 0GC Y LA AMBIENTAL, DURANTE 2 A 72 H. LOS PRODUCTOS IA Y IB PUEDEN TRANSFORMARSE RESPECTIVAMENTE EN LOS PRODUCTOS IC Y ID POR REACCION CON UN HALURO DE ALQUILO INFERIOR, A 20-120GC, DURANTE 1 A 72 HORAS.
ES8900754A 1989-03-02 1989-03-02 Procedimiento para la obtencion de derivados de la 2-picolilamina. Expired ES2010145A6 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES8900754A ES2010145A6 (es) 1989-03-02 1989-03-02 Procedimiento para la obtencion de derivados de la 2-picolilamina.
CA002011277A CA2011277A1 (en) 1989-03-02 1990-03-01 2-picolylamine derivatives
US07/487,476 US5134151A (en) 1989-03-02 1990-03-02 2-picolylamine derivatives
JP2051594A JPH0334968A (ja) 1989-03-02 1990-03-02 新規２‐ピコリルアミン誘導体
EP19900104051 EP0385490A1 (en) 1989-03-02 1990-03-02 2-picolylamine derivates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8900754A ES2010145A6 (es) 1989-03-02 1989-03-02 Procedimiento para la obtencion de derivados de la 2-picolilamina.

Publications (1)

Publication Number Publication Date
ES2010145A6 true ES2010145A6 (es) 1989-10-16

Family

ID=8260723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900754A Expired ES2010145A6 (es) 1989-03-02 1989-03-02 Procedimiento para la obtencion de derivados de la 2-picolilamina.

Country Status (5)

Country Link
US (1) US5134151A (es)
EP (1) EP0385490A1 (es)
JP (1) JPH0334968A (es)
CA (1) CA2011277A1 (es)
ES (1) ES2010145A6 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599265A1 (en) * 1992-11-24 1994-06-01 Takeda Chemical Industries, Ltd. Antibacterial, antifungal compound and its production method

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208247A (en) * 1991-08-01 1993-05-04 American Cyanamid Company Pyridinium compounds which are useful as antagonists of platelet activating factor
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
KR20020033707A (ko) * 2002-04-09 2002-05-07 임정진 길이조절이 가능한 롤러브레이드
GB0222522D0 (en) * 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2011051916A2 (en) * 2009-11-02 2011-05-05 Universite De Geneve Stabilized protein formulations and use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57165394A (en) * 1981-04-02 1982-10-12 Ono Pharmaceut Co Ltd Phospholipid derivative, its preparation, and blood platelet activating factor antagonistic agent contraining the same
JPH0240648B2 (ja) * 1981-08-25 1990-09-12 Takeda Chemical Industries Ltd Ketsushobankatsuseiinshokuseizai
JPS6081194A (ja) * 1983-10-11 1985-05-09 Takeda Chem Ind Ltd ケトアルキルリン脂質
DK160818C (da) * 1983-12-30 1991-10-07 Hoffmann La Roche N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse
DE3586746T2 (de) * 1984-04-03 1993-03-04 Takeda Chemical Industries Ltd Lipidderivate, ihre produktion und verwendung.
WO1986001507A1 (en) * 1984-08-23 1986-03-13 Sandoz Ag Cyclimmonium salts
ZA857808B (en) * 1984-10-10 1987-05-27 Sandoz Ltd Substituted 2-furanyl or 5-oxo-2-furanylalkoxy phospherol alkyl cyclimmonium salts
EP0178261A3 (en) * 1984-10-10 1986-12-30 Sandoz Ag Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts
US4663333A (en) * 1985-02-04 1987-05-05 G. D. Searle & Co. Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions
DE3663255D1 (en) * 1985-07-26 1989-06-15 Sankyo Co Phosphate ester derivatives, their preparation and their therapeutic use
JP2556849B2 (ja) * 1986-02-13 1996-11-27 三共株式会社 グリセリン誘導体
KR950002551B1 (en) * 1986-07-04 1995-03-21 Sankyo Co Cyclic ether derivatives, their preparation and use
JP2561478B2 (ja) * 1986-07-22 1996-12-11 武田薬品工業株式会社 グリセリン誘導体
DE3871705T2 (de) * 1987-10-13 1992-12-17 Uriach & Cia Sa J 2,4-disubstituierte tetrahydrofuranderivate.
ES2005031A6 (es) * 1987-10-13 1989-02-16 Uriach & Cia Sa J Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599265A1 (en) * 1992-11-24 1994-06-01 Takeda Chemical Industries, Ltd. Antibacterial, antifungal compound and its production method

Also Published As

Publication number Publication date
EP0385490A1 (en) 1990-09-05
US5134151A (en) 1992-07-28
CA2011277A1 (en) 1990-09-02
JPH0334968A (ja) 1991-02-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301