ES8507502A1 - Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas - Google Patents

Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas

Info

Publication number
ES8507502A1
ES8507502A1 ES529577A ES529577A ES8507502A1 ES 8507502 A1 ES8507502 A1 ES 8507502A1 ES 529577 A ES529577 A ES 529577A ES 529577 A ES529577 A ES 529577A ES 8507502 A1 ES8507502 A1 ES 8507502A1
Authority
ES
Spain
Prior art keywords
pyrazol
ones
anthra
substituted
substituted anthra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529577A
Other languages
English (en)
Other versions
ES529577A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/507,961 external-priority patent/US4556654A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8507502A1 publication Critical patent/ES8507502A1/es
Publication of ES529577A0 publication Critical patent/ES529577A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
    • C09B5/02—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic ring being only condensed in peri position
    • C09B5/16—Benz-diazabenzanthrones, e.g. anthrapyrimidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ANTRA 1,9-C,D PIRAZOL-6(2H)-ONAS, DE FORMULA ESTRUCTURAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), CON UNA HIDRAZINA DE FORMULA GENERAL: H2N-NHZ, EN LAS QUE Q Y Q PUEDEN SER IGUALES O DIFERENTES Y SIGNIFICAN H, OH, BENCILOXI O P-METOXIBENCILOXI; Y Z ES HIDROGENO O ALQUILO DE UNO A SEIS ATOMOS DE CARBONO.DE APLICACION EN EL TRATAMIENTO DE TUMORES SOLIDOS EN MAMIFEROS, CONSISTENTE EN LA ADMINISTRACION DE UNA CANTIDAD SUFICIENTE DE DICHO COMPUESTO O DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN COMBINACION CON UN VEHICULO FISIOLOGICAMENTE ACEPTABLE.
ES529577A 1982-07-23 1984-02-09 Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas Granted ES529577A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40115782A 1982-07-23 1982-07-23
US06/507,961 US4556654A (en) 1983-06-28 1983-06-28 Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones

Publications (2)

Publication Number Publication Date
ES8507502A1 true ES8507502A1 (es) 1985-09-01
ES529577A0 ES529577A0 (es) 1985-09-01

Family

ID=27017319

Family Applications (3)

Application Number Title Priority Date Filing Date
ES524380A Expired ES8504731A1 (es) 1982-07-23 1983-07-22 Un procedimiento para preparar antra 1,9-cd-7pirazol-6(2h)-onas
ES529578A Expired ES8507503A1 (es) 1982-07-23 1984-02-09 Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas
ES529577A Granted ES529577A0 (es) 1982-07-23 1984-02-09 Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES524380A Expired ES8504731A1 (es) 1982-07-23 1983-07-22 Un procedimiento para preparar antra 1,9-cd-7pirazol-6(2h)-onas
ES529578A Expired ES8507503A1 (es) 1982-07-23 1984-02-09 Un procedimiento para preparar antra (1, 9-cd) pirazol-6(2h)-onas

Country Status (18)

Country Link
EP (1) EP0103381B1 (es)
JP (2) JPH072719B2 (es)
KR (1) KR900005026B1 (es)
AR (1) AR240315A1 (es)
AU (1) AU549659B2 (es)
CA (1) CA1230115A (es)
DE (1) DE3373811D1 (es)
DK (3) DK159429C (es)
ES (3) ES8504731A1 (es)
FI (1) FI82932C (es)
GR (1) GR79610B (es)
HU (1) HU195779B (es)
IE (1) IE56782B1 (es)
IL (1) IL69211A (es)
NO (1) NO160000C (es)
NZ (1) NZ205001A (es)
PH (1) PH20906A (es)
PT (1) PT77088B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1251451A (en) * 1984-06-29 1989-03-21 Ellen M. Berman Benzoseleno¬4,3,2-cd|indazole compositions and methods for their production and use
CA1251450A (en) * 1984-06-29 1989-03-21 David B. Capps Benzopyrano¬4,3,2-cd|indazole compositions and methods for their production and use
US4608439A (en) * 1985-04-26 1986-08-26 Warner-Lambert Company Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
US4672129A (en) * 1986-05-05 1987-06-09 Warner-Lambert Company Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
GB9107852D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9107843D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
JP3497168B2 (ja) * 1992-09-08 2004-02-16 ザ・ユニバーシティ・オブ・バーモント 抗腫瘍活性を有する２−アミノアルキル−５−アミノアルキルアミノ置換イソキノインダゾール−６−（２ｈ）−オン類
US5393886A (en) * 1993-05-05 1995-02-28 The Du Pont Merck Pharmaceutical Company Intermediates for the synthesis of anthrapyrazolone anticancer agents
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
IT1277576B1 (it) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
WO2008116161A2 (en) 2007-03-22 2008-09-25 The General Hospital Corporation Pyrazoloanthrone and derivatives thereof for the treatment of cancer expressing 'mullerian inhibiting substance' type ii receptor (misrii) and of excess androgen states

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH191142A (de) * 1936-02-07 1937-05-31 Chem Ind Basel Verfahren zur Herstellung eines Anthrachinonderivates.
GB470475A (en) * 1936-02-14 1937-08-16 Of Chemical Industry Soc Manufacture of dyestuffs and intermediate products
US2518150A (en) * 1946-02-01 1950-08-08 Ciba Ltd Vat dyestuffs
DE2558812A1 (de) * 1975-12-27 1977-07-07 Hoechst Ag Lichtempfindliche kopiermassen und darin enthaltene photoinitiatoren

Also Published As

Publication number Publication date
DK430389D0 (da) 1989-08-31
DK160251B (da) 1991-02-18
IE56782B1 (en) 1991-12-18
KR900005026B1 (ko) 1990-07-18
JPH072719B2 (ja) 1995-01-18
AU549659B2 (en) 1986-02-06
NO160000B (no) 1988-11-21
HU195779B (en) 1988-07-28
JPH07179389A (ja) 1995-07-18
DE3373811D1 (en) 1987-10-29
NO832659L (no) 1984-01-24
IL69211A0 (en) 1983-11-30
IL69211A (en) 1987-01-30
DK329683D0 (da) 1983-07-18
ES524380A0 (es) 1985-04-16
FI82932B (fi) 1991-01-31
GR79610B (es) 1984-10-31
JPH07110829B2 (ja) 1995-11-29
PH20906A (en) 1987-05-27
DK430389A (da) 1989-08-31
DK159429B (da) 1990-10-15
ES529578A0 (es) 1985-09-01
DK159429C (da) 1991-03-18
DK430289A (da) 1989-08-31
NZ205001A (en) 1986-09-10
FI82932C (fi) 1991-05-10
AR240315A1 (es) 1990-03-30
DK159849C (da) 1991-05-13
ES8504731A1 (es) 1985-04-16
KR840005431A (ko) 1984-11-12
DK159849B (da) 1990-12-17
DK329683A (da) 1984-01-24
DK430289D0 (da) 1989-08-31
EP0103381B1 (en) 1987-09-23
EP0103381A1 (en) 1984-03-21
FI832638A0 (fi) 1983-07-20
FI832638A (fi) 1984-01-24
DK160251C (da) 1991-07-22
NO160000C (no) 1989-03-01
PT77088A (en) 1983-08-01
AU1681083A (en) 1984-01-26
CA1230115A (en) 1987-12-08
ES8507503A1 (es) 1985-09-01
ES529577A0 (es) 1985-09-01
IE831622L (en) 1984-01-23
PT77088B (en) 1986-02-12
CA1251442C (es) 1989-03-21
JPS5951268A (ja) 1984-03-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050207