CA1230115A - Substituted anthra[1,9-cd]pyrazol-6(2h)-ones - Google Patents

Substituted anthra[1,9-cd]pyrazol-6(2h)-ones

Info

Publication number
CA1230115A
CA1230115A CA000432584A CA432584A CA1230115A CA 1230115 A CA1230115 A CA 1230115A CA 000432584 A CA000432584 A CA 000432584A CA 432584 A CA432584 A CA 432584A CA 1230115 A CA1230115 A CA 1230115A
Authority
CA
Canada
Prior art keywords
pyrazol
ones
substituted anthra
anthra
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000432584A
Other languages
French (fr)
Other versions
CA1251442C (en
Inventor
Howard D H Showalter
Judith L Johnson
Leslie M Werbel
Edward F Elslager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/507,961 external-priority patent/US4556654A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to CA000550173A priority Critical patent/CA1248097A/en
Priority to CA000550175A priority patent/CA1251442A/en
Priority to CA000550174A priority patent/CA1256431A/en
Publication of CA1230115A publication Critical patent/CA1230115A/en
Application granted granted Critical
Publication of CA1251442C publication Critical patent/CA1251442C/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
    • C09B5/02—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic ring being only condensed in peri position
    • C09B5/16—Benz-diazabenzanthrones, e.g. anthrapyrimidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Abstract

Substituted anthra¢1,9-cd!pyrazol-6(2H)-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.
CA000432584A 1982-07-23 1983-07-18 Substituted anthra[1,9-cd]pyrazol-6(2h)-ones Expired CA1230115A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA000550173A CA1248097A (en) 1982-07-23 1987-10-23 Intermediates for substituted anthra¬1-9-cd|- pyrazol-6(2h)-ones
CA000550175A CA1251442A (en) 1982-07-23 1987-10-23 Intermediates for substituted anthra¬1,9-cd|- pyrazol-6(2h)-ones
CA000550174A CA1256431A (en) 1982-07-23 1987-10-23 Substituted anthra¬1,9-cd|pyrazol-6-(2h)-ones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40115782A 1982-07-23 1982-07-23
US06/507,961 US4556654A (en) 1983-06-28 1983-06-28 Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000550173A Division CA1248097A (en) 1982-07-23 1987-10-23 Intermediates for substituted anthra¬1-9-cd|- pyrazol-6(2h)-ones

Publications (2)

Publication Number Publication Date
CA1230115A true CA1230115A (en) 1987-12-08
CA1251442C CA1251442C (en) 1989-03-21

Family

ID=27017319

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000432584A Expired CA1230115A (en) 1982-07-23 1983-07-18 Substituted anthra[1,9-cd]pyrazol-6(2h)-ones

Country Status (18)

Country Link
EP (1) EP0103381B1 (en)
JP (2) JPH072719B2 (en)
KR (1) KR900005026B1 (en)
AR (1) AR240315A1 (en)
AU (1) AU549659B2 (en)
CA (1) CA1230115A (en)
DE (1) DE3373811D1 (en)
DK (3) DK159429C (en)
ES (3) ES524380A0 (en)
FI (1) FI82932C (en)
GR (1) GR79610B (en)
HU (1) HU195779B (en)
IE (1) IE56782B1 (en)
IL (1) IL69211A (en)
NO (1) NO160000C (en)
NZ (1) NZ205001A (en)
PH (1) PH20906A (en)
PT (1) PT77088B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1251450A (en) * 1984-06-29 1989-03-21 David B. Capps Benzopyrano¬4,3,2-cd|indazole compositions and methods for their production and use
CA1251451A (en) * 1984-06-29 1989-03-21 Ellen M. Berman Benzoseleno¬4,3,2-cd|indazole compositions and methods for their production and use
US4608439A (en) * 1985-04-26 1986-08-26 Warner-Lambert Company Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
US4672129A (en) * 1986-05-05 1987-06-09 Warner-Lambert Company Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
GB9107852D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9107843D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
PT662076E (en) * 1992-09-08 2001-09-28 Univ Vermont 2-AMINOALQUIL-5-AMINOALQUILAMINO-ACTIVITY-ACTIVITY-REPLACED ISOKININDAZOL-6- (2H) -ONES
US5393886A (en) * 1993-05-05 1995-02-28 The Du Pont Merck Pharmaceutical Company Intermediates for the synthesis of anthrapyrazolone anticancer agents
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
IT1277576B1 (en) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2- (2-HYDROXYETHYL) AMINO ETHYL -5- 2-METHYLAMINO ETHYL AMINO INDAZOLE 4,3-GH ISOCHINOLIN-6 (2H) -ONE AS ANTI-TUMOR AGENT
US20100233689A1 (en) 2007-03-22 2010-09-16 The General Hospital Corporation Pyrazoloanthrone and derivatives thereof for the treatment of cancer expressing 'mullerian inhibiting substance' type ii receptor (misrii) and of excess androgen states

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH191142A (en) * 1936-02-07 1937-05-31 Chem Ind Basel Process for the production of an anthraquinone derivative.
GB470475A (en) * 1936-02-14 1937-08-16 Of Chemical Industry Soc Manufacture of dyestuffs and intermediate products
US2518150A (en) * 1946-02-01 1950-08-08 Ciba Ltd Vat dyestuffs
DE2558812A1 (en) * 1975-12-27 1977-07-07 Hoechst Ag LIGHT-SENSITIVE COPY DIMENSIONS AND CONTAINED PHOTOINITIATORS

Also Published As

Publication number Publication date
GR79610B (en) 1984-10-31
AU549659B2 (en) 1986-02-06
IE56782B1 (en) 1991-12-18
ES8504731A1 (en) 1985-04-16
JPH072719B2 (en) 1995-01-18
DK159429C (en) 1991-03-18
DK159429B (en) 1990-10-15
DK430389A (en) 1989-08-31
FI82932B (en) 1991-01-31
IL69211A0 (en) 1983-11-30
KR840005431A (en) 1984-11-12
EP0103381A1 (en) 1984-03-21
FI82932C (en) 1991-05-10
ES8507503A1 (en) 1985-09-01
ES529577A0 (en) 1985-09-01
NO832659L (en) 1984-01-24
DK430389D0 (en) 1989-08-31
IL69211A (en) 1987-01-30
HU195779B (en) 1988-07-28
NO160000C (en) 1989-03-01
ES8507502A1 (en) 1985-09-01
JPH07179389A (en) 1995-07-18
DK159849B (en) 1990-12-17
JPH07110829B2 (en) 1995-11-29
DK160251C (en) 1991-07-22
DE3373811D1 (en) 1987-10-29
ES524380A0 (en) 1985-04-16
NZ205001A (en) 1986-09-10
DK430289A (en) 1989-08-31
DK430289D0 (en) 1989-08-31
AU1681083A (en) 1984-01-26
ES529578A0 (en) 1985-09-01
DK329683D0 (en) 1983-07-18
PH20906A (en) 1987-05-27
DK160251B (en) 1991-02-18
JPS5951268A (en) 1984-03-24
NO160000B (en) 1988-11-21
FI832638A0 (en) 1983-07-20
DK159849C (en) 1991-05-13
DK329683A (en) 1984-01-24
IE831622L (en) 1984-01-23
AR240315A1 (en) 1990-03-30
FI832638A (en) 1984-01-24
EP0103381B1 (en) 1987-09-23
KR900005026B1 (en) 1990-07-18
CA1251442C (en) 1989-03-21
PT77088A (en) 1983-08-01
PT77088B (en) 1986-02-12

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Legal Events

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