DK160818C - N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse - Google Patents

N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse

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Publication number
DK160818C
DK160818C DK514284A DK514284A DK160818C DK 160818 C DK160818 C DK 160818C DK 514284 A DK514284 A DK 514284A DK 514284 A DK514284 A DK 514284A DK 160818 C DK160818 C DK 160818C
Authority
DK
Denmark
Prior art keywords
preparation
processes
compound
platelet activation
activation factor
Prior art date
Application number
DK514284A
Other languages
English (en)
Other versions
DK514284D0 (da
DK514284A (da
DK160818B (da
Inventor
Richard Barner
Kaspar Burri
Jean-Marie Cassal
Paul Hadvary
Georges Hirth
Klaus Mueller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK514284D0 publication Critical patent/DK514284D0/da
Publication of DK514284A publication Critical patent/DK514284A/da
Publication of DK160818B publication Critical patent/DK160818B/da
Application granted granted Critical
Publication of DK160818C publication Critical patent/DK160818C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20Quaternary compounds thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
DK514284A 1983-12-30 1984-10-26 N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse DK160818C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH698583 1983-12-30
CH698583 1983-12-30
CH449884 1984-09-20
CH449884 1984-09-20

Publications (4)

Publication Number Publication Date
DK514284D0 DK514284D0 (da) 1984-10-26
DK514284A DK514284A (da) 1985-07-01
DK160818B DK160818B (da) 1991-04-22
DK160818C true DK160818C (da) 1991-10-07

Family

ID=25695617

Family Applications (2)

Application Number Title Priority Date Filing Date
DK514284A DK160818C (da) 1983-12-30 1984-10-26 N-ring-holdige glycerolderivater, fremgangsmaade til fremstilling deraf, anvendelse deraf til fremstilling af et blodpladeaktiveringsfaktorhaemmende middel samt laegemidler indeholdende en saadan forbindelse
DK200590A DK200590D0 (da) 1983-12-30 1990-08-21 Glycerolderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK200590A DK200590D0 (da) 1983-12-30 1990-08-21 Glycerolderivater

Country Status (15)

Country Link
US (1) US4731373A (da)
EP (1) EP0147768B1 (da)
AU (1) AU571625B2 (da)
CA (1) CA1266476A (da)
DE (1) DE3476661D1 (da)
DK (2) DK160818C (da)
ES (2) ES539136A0 (da)
FI (1) FI82686C (da)
HU (1) HU195775B (da)
IL (1) IL73920A (da)
MC (1) MC1639A1 (da)
NO (1) NO165192C (da)
NZ (1) NZ210633A (da)
PH (1) PH21482A (da)
PT (1) PT79783B (da)

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AU4727085A (en) * 1984-08-23 1986-03-24 Sandoz Ag Cyclimmonium salts
US4863941A (en) * 1985-06-18 1989-09-05 Hoffmann-La Roche Inc. Glycerol derivatives
GB8528959D0 (en) * 1985-11-25 1986-01-02 Leo Pharm Prod Ltd Chemical compounds
US5089657A (en) * 1987-03-11 1992-02-18 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
EP0301751B1 (en) * 1987-07-31 1993-03-10 Takeda Chemical Industries, Ltd. Pyridinium derivatives, their production and use
US4920134A (en) * 1987-08-07 1990-04-24 Takeda Chemical Industries, Ltd. 2-O-pyrimidinyl glycerol derivatives
ES2005031A6 (es) * 1987-10-13 1989-02-16 Uriach & Cia Sa J Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.
WO1989007100A1 (en) * 1988-02-05 1989-08-10 Schering Corporation 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use
WO1989007099A1 (en) * 1988-02-05 1989-08-10 Schering Corporation 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use
US5185334A (en) * 1989-07-31 1993-02-09 Schering Corporation 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use
EP0336142A3 (en) * 1988-04-04 1991-04-24 American Cyanamid Company Novel antagonists of platelet activating factor
US5273985A (en) * 1988-07-04 1993-12-28 Eisai Co., Ltd. Glycerin derivative and its pharmacological use
FI97883C (fi) * 1988-07-04 1997-03-10 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen glyserolijohdannaisen valmistamiseksi
EP0356765A3 (en) * 1988-08-19 1991-08-07 Takeda Chemical Industries, Ltd. Carboxylic acid derivatives, their production and use
US4981860A (en) * 1989-01-30 1991-01-01 Takeda Chemical Industries, Ltd. Pyridinium nitrate, composition containing same and their use for inhibiting platelet activating factor
ES2013834A6 (es) * 1989-01-30 1990-06-01 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 4-sustituidos de 2-alcoxitetrahidrofurano.
ES2010145A6 (es) * 1989-03-02 1989-10-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados de la 2-picolilamina.
US5391785A (en) * 1990-01-16 1995-02-21 La Jolla Pharmaceutial Company Intermediates for providing functional groups on the 5' end of oligonucleotides
IE922292A1 (en) * 1991-07-15 1993-01-27 Jolla Pharma Modified phosphorous intermediates for providing functional¹groups on the 5' end of oligonucleotides
ES2062943B1 (es) * 1993-03-23 1995-11-16 Uriach & Cia Sa J Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
AU2001268228A1 (en) * 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
RU2414453C2 (ru) * 2008-07-17 2011-03-20 Сергей Иванович МАЛЕКИН 1-алкил-2-алкилкарбамоил-глицерины, обладающие антигипертензивной активностью, и способ их получения
JP6233303B2 (ja) 2012-03-30 2017-11-22 三菱ケミカル株式会社 エポキシ化合物の製造方法及びエポキシ化反応用触媒組成物
RU2621347C1 (ru) * 2016-05-27 2017-06-02 Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет "Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) Способ получения 1-алкил-2-алкилкарбамоилглицеринов

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DE932611C (de) * 1949-12-22 1955-09-05 Ciba Geigy Verfahren zur Herstellung von Polyalkylenglykolaethern isocyclischer Verbindungen
DE1199254B (de) * 1963-09-20 1965-08-26 Krewel Leuffen Gmbh Verfahren zur Herstellung von O, N-Dicarbaethoxyderivaten von substituierten 1, 3-Aminoalkoholen
NL133296C (da) * 1966-12-30
DE1954718A1 (de) * 1968-11-02 1970-06-18 Sumitomo Chemical Co Wasserloesliche antibakterielle Verbindungen und Verfahren zu ihrer Herstellung
US3686238A (en) * 1970-01-19 1972-08-22 Syntex Corp Glycerol esterified with 2-naphthyl-acetic acids and fatty acids
US3671557A (en) * 1970-09-17 1972-06-20 Smith Kline French Lab 1,2-diacylglycerol 3-(2,2,2-trichloroethyl) carbonates
DE2422170C2 (de) * 1974-05-08 1982-09-23 Bayer Ag, 5090 Leverkusen Polymerisierbare N,N-disubstituierte Carbamoyloxyalkylcarbonsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung
DD121507B1 (de) * 1975-09-29 1989-11-29 Hans Brachwitz Verfahren zur herstellung von 1-o-acyl-und 1-0-alkyl-2-halogenpropandiol-(1,3)
GB1514389A (en) * 1975-12-08 1978-06-14 Abbott Lab Glycerides with antibacterial properties
DE2820892A1 (de) * 1978-05-12 1979-11-22 Nattermann A & Cie Neue strukturanaloga von glyveriden und verfahren zu deren herstellung
US4551532A (en) * 1980-05-08 1985-11-05 Takeda Chemical Industries, Ltd. Ethylene glycol derivatives having anti-protozoan, anti-fungal and anti-tumor activity
EP0054715A3 (de) * 1980-12-18 1982-09-22 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Propionsäureester, Herstellung dieser Verbindungen, Unkrautbekämpfungsmittel, die diese Verbindungen als Wirkstoffe enthalten, sowie Verwendung solcher Verbindungen und Mittel zur Bekämpfung von Unkräutern
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
JPS58192825A (ja) * 1982-05-06 1983-11-10 Takeda Chem Ind Ltd グリセロール誘導体
EP0094586A3 (en) * 1982-05-13 1984-06-06 Ono Pharmaceutical Co., Ltd. Glycerol derivatives, process for preparing same and pharmaceutical composition containing same
JPS5988447A (ja) * 1982-11-11 1984-05-22 Ono Pharmaceut Co Ltd グリセリン誘導体、その製造方法及びその誘導体を含有する薬剤
JPS60104066A (ja) * 1983-11-10 1985-06-08 Ono Pharmaceut Co Ltd グリセリン誘導体

Also Published As

Publication number Publication date
FI82686C (fi) 1991-04-10
DE3476661D1 (en) 1989-03-16
IL73920A0 (en) 1985-03-31
ES547020A0 (es) 1986-11-16
MC1639A1 (fr) 1986-01-09
DK514284D0 (da) 1984-10-26
EP0147768A2 (de) 1985-07-10
PH21482A (en) 1987-10-28
HUT37112A (en) 1985-11-28
CA1266476A (en) 1990-03-06
NO165192B (no) 1990-10-01
DK514284A (da) 1985-07-01
DK200590A (da) 1990-08-21
ES8603374A1 (es) 1986-01-01
ES8701138A1 (es) 1986-11-16
NO165192C (no) 1991-01-09
FI82686B (fi) 1990-12-31
IL73920A (en) 1988-06-30
PT79783B (en) 1987-01-05
PT79783A (en) 1985-01-01
AU3719684A (en) 1985-07-04
ES539136A0 (es) 1986-01-01
FI844332A0 (fi) 1984-11-05
AU571625B2 (en) 1988-04-21
NZ210633A (en) 1988-08-30
US4731373A (en) 1988-03-15
DK200590D0 (da) 1990-08-21
NO844635L (no) 1985-07-01
EP0147768A3 (en) 1985-10-09
DK160818B (da) 1991-04-22
EP0147768B1 (de) 1989-02-08
HU195775B (en) 1988-07-28
FI844332L (fi) 1985-07-01

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Legal Events

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PBP Patent lapsed
AHS Application shelved for other reasons than non-payment