ES8706645A1 - Un procedimiento para preparar derivados de dihidropiridazinona - Google Patents

Un procedimiento para preparar derivados de dihidropiridazinona

Info

Publication number
ES8706645A1
ES8706645A1 ES554965A ES554965A ES8706645A1 ES 8706645 A1 ES8706645 A1 ES 8706645A1 ES 554965 A ES554965 A ES 554965A ES 554965 A ES554965 A ES 554965A ES 8706645 A1 ES8706645 A1 ES 8706645A1
Authority
ES
Spain
Prior art keywords
compounds
formula
dihydropyridazinones
hydrogon
bronchodilating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554965A
Other languages
English (en)
Other versions
ES554965A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES554965A0 publication Critical patent/ES554965A0/es
Publication of ES8706645A1 publication Critical patent/ES8706645A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE DIHIDROPIRIDAZINONA. CONSISTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) DONDE X ES UN GRUPO DESPLAZABLE, CON HIDRAZINA O UN EQUIVALENTE QUIMICO DE LA MISMA; O B) HACER REACCIONAR UN COMPUESTO DE FORMULA (III) DONDE A ES UN GRUPO DESPLAZABLE, CON CIANAMIDA O UNA SAL DE METAL PESADO DE LA MISMA, PARA OBTENER DERIVADOS DE DIHIDROPIRIDAZINONA DE FORMULA (I) DONDE R ELEVADO A 1 ES HIDROGENO O METILO Y R ELEVADO A 2 ES HIDROGENO O ALQUILO DE C 1 A 4. TIENEN APLICACIONES FARMACEUTICAS POR SUS EFECTOS VASODILATADORES. *FORMULA*
ES554965A 1984-01-13 1986-05-14 Un procedimiento para preparar derivados de dihidropiridazinona Expired ES8706645A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848400863A GB8400863D0 (en) 1984-01-13 1984-01-13 Chemical compounds

Publications (2)

Publication Number Publication Date
ES554965A0 ES554965A0 (es) 1987-07-01
ES8706645A1 true ES8706645A1 (es) 1987-07-01

Family

ID=10554924

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539446A Expired ES8607949A1 (es) 1984-01-13 1985-01-10 Un procedimiento para preparar un derivado de dihidropiridazinona
ES549629A Expired ES8703846A1 (es) 1984-01-13 1985-12-05 Un procedimiento para preparar derivados de dihidropiridazi-nona
ES554965A Expired ES8706645A1 (es) 1984-01-13 1986-05-14 Un procedimiento para preparar derivados de dihidropiridazinona

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES539446A Expired ES8607949A1 (es) 1984-01-13 1985-01-10 Un procedimiento para preparar un derivado de dihidropiridazinona
ES549629A Expired ES8703846A1 (es) 1984-01-13 1985-12-05 Un procedimiento para preparar derivados de dihidropiridazi-nona

Country Status (31)

Country Link
US (1) US4654342A (es)
EP (1) EP0150937B1 (es)
JP (3) JPS60158181A (es)
KR (1) KR920006781B1 (es)
CN (1) CN85101722A (es)
AT (1) ATE37179T1 (es)
AU (1) AU572252B2 (es)
CA (2) CA1251209A (es)
CS (1) CS248731B2 (es)
DD (1) DD231350A5 (es)
DE (1) DE3564941D1 (es)
DK (1) DK162519C (es)
ES (3) ES8607949A1 (es)
FI (1) FI850140L (es)
GB (1) GB8400863D0 (es)
GR (1) GR850068B (es)
HU (1) HU193591B (es)
IE (1) IE57969B1 (es)
IL (1) IL74031A (es)
JO (1) JO1351B1 (es)
MY (1) MY100124A (es)
NO (1) NO850129L (es)
NZ (1) NZ210816A (es)
PH (1) PH22136A (es)
PL (1) PL147123B1 (es)
PT (1) PT79819B (es)
RO (1) RO92607A (es)
SU (1) SU1396963A3 (es)
WO (1) WO1985003076A1 (es)
ZA (1) ZA85251B (es)
ZW (1) ZW385A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1251448A (en) * 1985-03-27 1989-03-21 William J. Coates Pyridazinone derivatives
US4946842A (en) * 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
GB8722776D0 (en) * 1987-09-28 1987-11-04 Smith Kline French Lab Chemical compounds
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
US6562821B2 (en) 2001-02-27 2003-05-13 Mitokor Aryl-N-cyanoguanidines and methods related thereto
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
CA2629367C (en) * 2005-11-14 2016-05-03 Boehringer Ingelheim Vetmedica Gmbh Use of pde iii inhibitors and/or calcium sensitizers for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP3239170B1 (en) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
KR20110089851A (ko) 2008-11-25 2011-08-09 베링거잉겔하임베트메디카게엠베하 비대 심근병증의 치료를 위한 포스포디에스테라제 타입 Ⅲ（ＰＤＥ Ⅲ） 억제제 또는 Ｃａ２＋―감작제
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
KR102455648B1 (ko) 2013-07-19 2022-10-19 베링거잉겔하임베트메디카게엠베하 보존된 에테르화된 사이클로덱스트린 유도체 함유 액체 수성 약제학적 조성물
IL280864B2 (en) 2013-08-09 2024-03-01 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
BE791539A (fr) * 1971-11-19 1973-05-17 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
EP0030835B1 (en) * 1979-12-05 1983-05-11 Morishita Pharmaceutical Co. Ltd. Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
EP0059688B1 (de) * 1981-03-04 1985-05-15 Ciba-Geigy Ag Pyridazinone, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen und deren Verwendung
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58140076A (ja) * 1982-02-09 1983-08-19 Mitsubishi Chem Ind Ltd ピリダジノン誘導体又はその塩類
DE3204375C2 (de) * 1982-02-09 1983-12-01 J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle Verfahren zur Herabsetzung der Saugfähigkeit von Holz
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
US4946842A (en) * 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants

Also Published As

Publication number Publication date
PT79819A (en) 1985-02-01
KR920006781B1 (ko) 1992-08-17
HUT37128A (en) 1985-11-28
CA1260471C (es) 1989-09-26
ATE37179T1 (de) 1988-09-15
GR850068B (es) 1985-05-03
PL251516A1 (en) 1985-12-17
ZW385A1 (en) 1985-08-07
ZA85251B (en) 1986-08-27
PL147123B1 (en) 1989-04-29
ES549629A0 (es) 1987-03-01
KR850005417A (ko) 1985-08-26
EP0150937B1 (en) 1988-09-14
IE850069L (en) 1985-07-13
EP0150937A3 (en) 1985-08-21
AU3761185A (en) 1985-07-18
RO92607A (ro) 1987-11-30
CN85101722A (zh) 1987-01-31
JPS60158181A (ja) 1985-08-19
DK162519C (da) 1992-03-30
HU193591B (en) 1987-11-30
NO850129L (no) 1985-07-15
DE3564941D1 (en) 1988-10-20
JPS63313775A (ja) 1988-12-21
CA1251209A (en) 1989-03-14
US4654342A (en) 1987-03-31
NZ210816A (en) 1987-06-30
JPS63313776A (ja) 1988-12-21
GB8400863D0 (en) 1984-02-15
MY100124A (en) 1989-12-18
IL74031A0 (en) 1985-04-30
CA1260471A (en) 1989-09-26
IL74031A (en) 1988-07-31
ES539446A0 (es) 1986-06-01
EP0150937A2 (en) 1985-08-07
IE57969B1 (en) 1993-06-02
CS248731B2 (en) 1987-02-12
WO1985003076A1 (en) 1985-07-18
SU1396963A3 (ru) 1988-05-15
AU572252B2 (en) 1988-05-05
DK9185D0 (da) 1985-01-08
ES554965A0 (es) 1987-07-01
DK162519B (da) 1991-11-11
ES8607949A1 (es) 1986-06-01
DD231350A5 (de) 1985-12-24
DK9185A (da) 1985-07-14
PT79819B (en) 1987-01-07
FI850140L (fi) 1985-07-14
PH22136A (en) 1988-06-01
JO1351B1 (en) 1986-11-30
FI850140A0 (fi) 1985-01-11
ES8703846A1 (es) 1987-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505