ES8506716A1 - Un metodo de preparar espiro (indolo (1, 7-ab) (1, 5)-benzodiazepin-2, 4'-piperidinas) - Google Patents
Un metodo de preparar espiro (indolo (1, 7-ab) (1, 5)-benzodiazepin-2, 4'-piperidinas)Info
- Publication number
- ES8506716A1 ES8506716A1 ES532507A ES532507A ES8506716A1 ES 8506716 A1 ES8506716 A1 ES 8506716A1 ES 532507 A ES532507 A ES 532507A ES 532507 A ES532507 A ES 532507A ES 8506716 A1 ES8506716 A1 ES 8506716A1
- Authority
- ES
- Spain
- Prior art keywords
- indolo
- benzodiazepine
- piperidines
- spiro
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ESPIROINDOLO1,7-AB 1,5-BENZODIAZEPIN-2,4K-PIPERIDINAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O METILO; R PUEDE SER VARIOS RADICALES; Y P Y Q VALEN 0 O 1.CONSISTE EN LA CICLODESHIDRATACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 ES HIDROGENO O METILO, EN PRESENCIA DE UN REACTIVO, ADECUADO, TAL COMO POCL3, A UNA TEMPERATURA COMPRENDIDA ENTRE 100JC Y 1205JC; SEGUIDA DE LA REDUCCION OPCIONAL DEL PRODUCTO FORMADO CON UN AGENTE REDUCTOR TAL COMO HIDRURO DE BORO Y SODIO, EN UN DISOLVENTE COMO ETANOL; TRATAMIENTO CON UN HALURO DE ACRILOILO, UNA AMINA Y BROMURO DE BROMOACETILO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANALGESICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/495,907 US4472414A (en) | 1983-05-18 | 1983-05-18 | Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines] |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8506716A1 true ES8506716A1 (es) | 1985-08-01 |
| ES532507A0 ES532507A0 (es) | 1985-08-01 |
Family
ID=23970472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532507A Granted ES532507A0 (es) | 1983-05-18 | 1984-05-16 | Un metodo de preparar espiro (indolo (1, 7-ab) (1, 5)-benzodiazepin-2, 4'-piperidinas) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4472414A (es) |
| EP (1) | EP0125679B1 (es) |
| JP (1) | JPS59219283A (es) |
| AT (1) | ATE42291T1 (es) |
| DE (1) | DE3477781D1 (es) |
| DK (1) | DK247784A (es) |
| ES (1) | ES532507A0 (es) |
| GR (1) | GR82272B (es) |
| PT (1) | PT78598B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547497A (en) * | 1984-04-11 | 1985-10-15 | Mcneilab, Inc. | Amidine benzodiazepines, methods for their use and intermediates |
| US4751223A (en) * | 1986-10-14 | 1988-06-14 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines |
| US4929615A (en) * | 1989-06-12 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals Inc. | 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines |
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| US5189161A (en) * | 1989-08-07 | 1993-02-23 | Hoechst Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209625A (en) * | 1977-04-21 | 1980-06-24 | American Hoechst Corporation | Spiro[indoline-3,4'-piperidine]s |
| US4186199A (en) * | 1978-11-02 | 1980-01-29 | American Hoechst Corporation | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines |
| US4192874A (en) * | 1978-11-02 | 1980-03-11 | American Hoechst Corporation | Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines |
-
1983
- 1983-05-18 US US06/495,907 patent/US4472414A/en not_active Expired - Fee Related
-
1984
- 1984-05-14 EP EP84105435A patent/EP0125679B1/en not_active Expired
- 1984-05-14 DE DE8484105435T patent/DE3477781D1/de not_active Expired
- 1984-05-14 AT AT84105435T patent/ATE42291T1/de not_active IP Right Cessation
- 1984-05-16 GR GR74737A patent/GR82272B/el unknown
- 1984-05-16 ES ES532507A patent/ES532507A0/es active Granted
- 1984-05-17 JP JP59097690A patent/JPS59219283A/ja active Pending
- 1984-05-17 DK DK247784A patent/DK247784A/da not_active Application Discontinuation
- 1984-05-17 PT PT78598A patent/PT78598B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR82272B (es) | 1984-12-13 |
| ES532507A0 (es) | 1985-08-01 |
| US4472414A (en) | 1984-09-18 |
| DE3477781D1 (en) | 1989-05-24 |
| EP0125679A3 (en) | 1985-07-31 |
| EP0125679B1 (en) | 1989-04-19 |
| JPS59219283A (ja) | 1984-12-10 |
| PT78598B (en) | 1986-07-17 |
| PT78598A (en) | 1984-06-01 |
| EP0125679A2 (en) | 1984-11-21 |
| DK247784D0 (da) | 1984-05-17 |
| ATE42291T1 (de) | 1989-05-15 |
| DK247784A (da) | 1984-11-19 |
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