DE3477781D1 - Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments - Google Patents

Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments

Info

Publication number
DE3477781D1
DE3477781D1 DE8484105435T DE3477781T DE3477781D1 DE 3477781 D1 DE3477781 D1 DE 3477781D1 DE 8484105435 T DE8484105435 T DE 8484105435T DE 3477781 T DE3477781 T DE 3477781T DE 3477781 D1 DE3477781 D1 DE 3477781D1
Authority
DE
Germany
Prior art keywords
indolo
benzodiazepine
piperidines
spiro
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484105435T
Other languages
English (en)
Inventor
Edward J Glamkowski
James M Fortunato
Richard C Allen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3477781D1 publication Critical patent/DE3477781D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484105435T 1983-05-18 1984-05-14 Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments Expired DE3477781D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/495,907 US4472414A (en) 1983-05-18 1983-05-18 Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines]

Publications (1)

Publication Number Publication Date
DE3477781D1 true DE3477781D1 (en) 1989-05-24

Family

ID=23970472

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484105435T Expired DE3477781D1 (en) 1983-05-18 1984-05-14 Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments

Country Status (9)

Country Link
US (1) US4472414A (de)
EP (1) EP0125679B1 (de)
JP (1) JPS59219283A (de)
AT (1) ATE42291T1 (de)
DE (1) DE3477781D1 (de)
DK (1) DK247784A (de)
ES (1) ES8506716A1 (de)
GR (1) GR82272B (de)
PT (1) PT78598B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547497A (en) * 1984-04-11 1985-10-15 Mcneilab, Inc. Amidine benzodiazepines, methods for their use and intermediates
US4751223A (en) * 1986-10-14 1988-06-14 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines
US4929615A (en) * 1989-06-12 1990-05-29 Hoechst-Roussel Pharmaceuticals Inc. 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
US5015738A (en) * 1989-08-07 1991-05-14 Hoechst-Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines
US5189161A (en) * 1989-08-07 1993-02-23 Hoechst Roussel Pharmaceuticals Inc. Benzo(b)pyrrolobenzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209625A (en) * 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
US4192874A (en) * 1978-11-02 1980-03-11 American Hoechst Corporation Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines
US4186199A (en) * 1978-11-02 1980-01-29 American Hoechst Corporation Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines

Also Published As

Publication number Publication date
EP0125679B1 (de) 1989-04-19
PT78598A (en) 1984-06-01
DK247784D0 (da) 1984-05-17
JPS59219283A (ja) 1984-12-10
PT78598B (en) 1986-07-17
DK247784A (da) 1984-11-19
ES532507A0 (es) 1985-08-01
US4472414A (en) 1984-09-18
GR82272B (de) 1984-12-13
EP0125679A2 (de) 1984-11-21
EP0125679A3 (en) 1985-07-31
ATE42291T1 (de) 1989-05-15
ES8506716A1 (es) 1985-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee