ES8704961A1 - Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas - Google Patents

Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas

Info

Publication number
ES8704961A1
ES8704961A1 ES548235A ES548235A ES8704961A1 ES 8704961 A1 ES8704961 A1 ES 8704961A1 ES 548235 A ES548235 A ES 548235A ES 548235 A ES548235 A ES 548235A ES 8704961 A1 ES8704961 A1 ES 8704961A1
Authority
ES
Spain
Prior art keywords
hydrogen
lower alkyl
independently
halogen
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548235A
Other languages
English (en)
Other versions
ES548235A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/772,984 external-priority patent/US4683223A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8704961A1 publication Critical patent/ES8704961A1/es
Publication of ES548235A0 publication Critical patent/ES548235A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

PROCEDIMIENTO DE PREPARACION DE N6-BENZOPIRANO Y BENZOTIOPIRANO-ADENOSINAS. CONSISTENTE EN LA OBTENCION DE COMPUESTOS DE FORMULA (I), DONDE R1 RESPONDE A LA EXPRESION (II) O (III); Y ES O, S, SO, SO2; X Y XK SON HIDROGENO, ALQUILO O ALCANOILO INFERIOR, HIDROXI, NITRO, AMINO O HALOGENO; A Y B SON HIDROGENO O ALQUILO INFERIOR; AK Y BK SON HIDROGENO, HALOGENO U OTROS RADICALES; RK2, RK3 Y RK5 SON HIDROGENO, ALCANOILO INFERIOR O BENZOILO; MEDIANTE REACCION DE UN RIBOSIDO DE 6-HALOPURINA DE FORMULA (III) CON LA AMINA CORRESPONDIENTE (II) O (III), EN DISOLVENTE APROTICO O INERTE, ENTRE 25JC Y 130JC, DURANTE 1 H A 48 H. DE APLICACION POR SU ACTIVIDAD ANALGESICA, ANTISICOTICA, SEDANTE O ANTIHIPERTENSIVA.
ES548235A 1984-10-26 1985-10-25 Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas Expired ES8704961A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66519784A 1984-10-26 1984-10-26
US06/772,984 US4683223A (en) 1985-09-09 1985-09-09 N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use

Publications (2)

Publication Number Publication Date
ES8704961A1 true ES8704961A1 (es) 1987-04-16
ES548235A0 ES548235A0 (es) 1987-04-16

Family

ID=27099144

Family Applications (2)

Application Number Title Priority Date Filing Date
ES548235A Expired ES8704961A1 (es) 1984-10-26 1985-10-25 Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas
ES557305A Expired ES8800255A1 (es) 1984-10-26 1987-01-13 Procedimiento para preparar n6 -benzopirano- y benzotiopirano-adenosinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557305A Expired ES8800255A1 (es) 1984-10-26 1987-01-13 Procedimiento para preparar n6 -benzopirano- y benzotiopirano-adenosinas.

Country Status (6)

Country Link
EP (1) EP0181109B1 (es)
AU (1) AU577743B2 (es)
CA (1) CA1255297A (es)
DE (1) DE3572824D1 (es)
DK (1) DK159454C (es)
ES (2) ES8704961A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU575438B2 (en) * 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
CN108599027A (zh) * 2018-05-25 2018-09-28 国家电网公司 一种新型电缆剥线装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2139107A1 (de) * 1971-08-04 1973-02-15 Merck Patent Gmbh Heterocyclisch substituierte adenosinverbindungen
CA1239397A (en) * 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines

Also Published As

Publication number Publication date
DK159454C (da) 1991-04-02
DK488185D0 (da) 1985-10-24
DK159454B (da) 1990-10-15
EP0181109A2 (en) 1986-05-14
AU577743B2 (en) 1988-09-29
DE3572824D1 (en) 1989-10-12
ES557305A0 (es) 1987-11-01
DK488185A (da) 1986-04-27
ES8800255A1 (es) 1987-11-01
AU4796485A (en) 1986-05-01
EP0181109A3 (en) 1987-05-13
CA1255297A (en) 1989-06-06
ES548235A0 (es) 1987-04-16
EP0181109B1 (en) 1989-09-06

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506