KR900003174A - 벤조푸로[3,2-c] 퀴놀린 화합물 - Google Patents

벤조푸로[3,2-c] 퀴놀린 화합물 Download PDF

Info

Publication number
KR900003174A
KR900003174A KR1019890002745A KR890002745A KR900003174A KR 900003174 A KR900003174 A KR 900003174A KR 1019890002745 A KR1019890002745 A KR 1019890002745A KR 890002745 A KR890002745 A KR 890002745A KR 900003174 A KR900003174 A KR 900003174A
Authority
KR
South Korea
Prior art keywords
group
following general
general formula
formula
represented
Prior art date
Application number
KR1019890002745A
Other languages
English (en)
Inventor
데쓰히데 가미조오
아라오 우지이에
히로무 하라다
나오유끼 쓰쓰미
아쓰시 쓰바끼
도시아끼 야마구찌
히데오 나가다
Original Assignee
간자와 구니오
깃세이 야꾸힝 고오교오 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 간자와 구니오, 깃세이 야꾸힝 고오교오 가부시끼가이샤 filed Critical 간자와 구니오
Publication of KR900003174A publication Critical patent/KR900003174A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

벤조푸로[3,2-c] 퀴놀린 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음의 일반식으로 나타내는 화합물
    상기식에서 1)R1과 R2는 서로 같으며, 식 -OR3의 기를 나타내고 여기서 R3은 카바모일기, N-모노-알킬카바모일기, N,N-디알킬카바모일기, 알킬술포닐기, 포르밀기 혹은 치환기로 알콕시카르보닐기를 가지기도 하는 지방족 아실기를 나타내며; m은 0,1 혹은 2를 나타내고 ;n은 0 혹은 1을 나타내며;단, m이 0일때 n은 0이 아니다. 2) R1과 R2는 서로 다르고 수산기 혹은 N,N-디알킬카바모일옥시기를 나타내며; M은 1 혹은 2를 나타내고;N은 1을 나타낸다.
  2. 제1항에 있어서, 다음의 일반식으로 나타내는 화합물.
    상기식에서 q는 1 혹은 2를 나타낸다.
  3. 제1항에 있어서, 다음의 일반식으로 나타내는 화합물.
    상기식에서 R8은 알킬기를 나타낸다.
  4. 제2항에 있어서, 다음의 일반식으로 나타내는 화합물.
  5. 제3항에 있어서, 다음의 일반식으로 나타내는 화합물.
  6. 다음의 일반식으로 나타내는 화합물로 이루어지는 골다공증의 예방과 치료를 위한 약학적 조성물.
    상기식에서 1)R1과 R2는 서로 같으며, 식 -OR3의 기를 나타내고 여기서 R3은 카바모일기, N-모노-알킬카바모일기, N,N-디알킬카바모일기, 알킬술포닐기, 포르밀기 혹은 치환기로 알콕시카르보닐기를 가지기도 하는 지방족 아실기를 나타내며; m은 0,1 혹은 2를 나타내고; n은 0 혹은 1을 나타내며; 단,m이 0일때 n은 0이 아니다. 2) R1과 R2는 서로 다르고 수산기 혹은 N,N-디알킬카바모일 옥시기를 나타내며; M은 1 혹은 2를 나타내고; N은 1을 나타낸다.
  7. 제6항에 있어서, 다음의 일반식으로 나타내는 화합물로 이루어지는 골다공증의 예방과 치료를 위한 약학적 조성물.
    상기식에서 q는 1 혹은 2를 나타낸다.
  8. 제6항에 있어서, 다음의 일반식으로 나타내는 화합물로 이루어지는 골다공증의 예방과 치료를 위한 약학적 조성물.
    상기식에서 R8은 알킬기를 나타낸다.
  9. 제7항에 있어서, 다음의 일반식으로 나타내는 화합물로 이루어지는 골다공증의 예방과 치료를 위한 약학적 조성물.
  10. 제8항에 있어서, 다음의 일반식으로 나타내는 화합물로 이루어지는 골다공증의 예방과 치료를 위한 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890002745A 1988-08-30 1989-03-06 벤조푸로[3,2-c] 퀴놀린 화합물 KR900003174A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-215755 1988-08-30
JP63215755A JPH0692410B2 (ja) 1988-08-30 1988-08-30 新規なベンゾフロキノリン誘導体

Publications (1)

Publication Number Publication Date
KR900003174A true KR900003174A (ko) 1990-03-23

Family

ID=16677687

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890002745A KR900003174A (ko) 1988-08-30 1989-03-06 벤조푸로[3,2-c] 퀴놀린 화합물

Country Status (8)

Country Link
US (1) US5023261A (ko)
EP (1) EP0357172A3 (ko)
JP (1) JPH0692410B2 (ko)
KR (1) KR900003174A (ko)
AU (1) AU624361B2 (ko)
DK (1) DK91989A (ko)
FI (1) FI891120A (ko)
NO (1) NO168358C (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370760A3 (en) * 1988-11-22 1991-07-24 Kissei Pharmaceutical Co., Ltd. Benzofuro[3,2-c]quinoline compounds
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries, Ltd. Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
JP2004075677A (ja) * 2002-06-21 2004-03-11 Toyama Chem Co Ltd 骨欠損治療および骨損傷の治癒促進剤
WO2006119148A2 (en) * 2005-04-29 2006-11-09 The Ohio State University Research Foundation Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis
US20190218226A1 (en) * 2016-02-04 2019-07-18 Purdue Research Foundation Prodrugs of anticancer agents indotecan and indimitecan
WO2017160898A1 (en) 2016-03-15 2017-09-21 Purdue Research Foundation Aza-a-ring indenoisoquinoline topoisomerase i poisons
KR102572721B1 (ko) 2016-05-19 2023-09-01 삼성디스플레이 주식회사 헤테로고리 화합물 및 이를 포함한 유기 발광 소자
CA3047992A1 (en) 2016-12-22 2018-06-28 Purdue Research Foundation Azaindenoisoquinoline compounds and uses thereof
CN110396094B (zh) * 2018-04-24 2021-10-12 华东师范大学 一种喹啉酮并杂芳环类化合物及其衍生物和合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017499A (en) * 1976-04-05 1977-04-12 Sandoz, Inc. 6H(1)-Benzopyrano(3,2-c)quinolines
JPS5413391A (en) * 1977-06-30 1979-01-31 Matsushita Electric Works Ltd Smoke sensor
JPS6048924A (ja) * 1983-08-24 1985-03-16 Takeda Chem Ind Ltd 骨粗鬆症治療剤
JPS6054379A (ja) * 1983-09-05 1985-03-28 Takeda Chem Ind Ltd 新規４ｈ−１−ベンゾピラン−４−オン誘導体，その製法および用途
JPS60132976A (ja) * 1983-12-21 1985-07-16 Takeda Chem Ind Ltd 新規３−フエニル−４ｈ−１−ベンゾピラン−４−オン誘導体
JPS60132917A (ja) * 1983-12-21 1985-07-16 Takeda Chem Ind Ltd 骨粗鬆症治療剤
JPS63101369A (ja) * 1986-10-17 1988-05-06 Mect Corp インデノキノリン系化合物、その製造法及びその化合物を有効成分とする抗癌剤
EP0293146A1 (en) * 1987-05-26 1988-11-30 Kissei Pharmaceutical Co. Ltd. Benzofuro [3,2-c] quinoline compounds
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法

Also Published As

Publication number Publication date
NO168358B (no) 1991-11-04
FI891120A (fi) 1990-03-01
JPH0262878A (ja) 1990-03-02
FI891120A0 (fi) 1989-03-09
AU3097789A (en) 1990-03-08
DK91989A (da) 1990-03-01
NO891027L (no) 1990-03-01
NO168358C (no) 1992-02-12
EP0357172A3 (en) 1991-03-27
AU624361B2 (en) 1992-06-11
EP0357172A2 (en) 1990-03-07
DK91989D0 (da) 1989-02-27
NO891027D0 (no) 1989-03-09
JPH0692410B2 (ja) 1994-11-16
US5023261A (en) 1991-06-11

Similar Documents

Publication Publication Date Title
FI931031A (fi) Mometasonfuroatmonohydrat, foerfarande foer dess framstaellning och farmaceutiska sammansaettningar
GR1001503B (el) Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
JPS5262213A (en) Polypluenyl derivatives
EP0339237A3 (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
KR900003174A (ko) 벤조푸로[3,2-c] 퀴놀린 화합물
SE8600632D0 (sv) Novel pharmaceutical composition
EP0031584A3 (en) 2-substituted-aminopropene- and propanenitrile compounds and antimicrobial and pharmaceutical, anti-inflammatory compositions
JPS5277073A (en) 1-carbamoyl-5-fluorouracil deruvative and anticancer drug containing s ame as effective component
JPS52108028A (en) Remedies for dysacousis
KR920020262A (ko) 포지티브 레지스트 조성물
FI932641A0 (fi) Nytt estradiolderivat-klorambucil-konjugat, foerfarande foer dess framstaellning och farmaceutiska kompositioner
KR830005168A (ko) 5-(디하이드록시페녹시)테트라졸의 제조방법
KR880013896A (ko) 벤조푸로[3,2-c]퀴놀린 화합물
KR840006657A (ko) 이소퀴놀린 화합물의 제조방법
KR880009644A (ko) 궤양성 대장질환 치료용 약한 조성물
JPS5259186A (en) Preparation of 3-cephem compounds by reduction
GB1495353A (en) Ascochlorin derivatives pharmaceutical composition containing the same and method of using the same
JPS51125722A (en) Germicides for industry and their preparation
KR920000319A (ko) 암 예방 방법
EP0043976A3 (en) Anti-tumor agent
JPS51123824A (en) A non-medical antibacterial and its preparation
KR840000235A (ko) 치환 히드록시벤젠류에 의한 2-레노일메르캅토프로피온일글리신의 에스테르 제조방법 및 이를 함유한 약제조성물
KR890001543A (ko) 당뇨병 치료제
KR870003089A (ko) 1-카바페넴 및 1-카바세펨 제조중간체의 제조방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid