KR830004320A - 퀴나졸린 유도체의 제조방법 - Google Patents

퀴나졸린 유도체의 제조방법 Download PDF

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Publication number
KR830004320A
KR830004320A KR1019800003887A KR800003887A KR830004320A KR 830004320 A KR830004320 A KR 830004320A KR 1019800003887 A KR1019800003887 A KR 1019800003887A KR 800003887 A KR800003887 A KR 800003887A KR 830004320 A KR830004320 A KR 830004320A
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KR
South Korea
Prior art keywords
formula
quinazoline derivatives
preparing
methylthio
lower alkyl
Prior art date
Application number
KR1019800003887A
Other languages
English (en)
Inventor
앤드류 레마휴 로날드
Original Assignee
쿠르트 내셀 보쉬, 한스 스튀클린
에프. 호프만-라 롯슈 앤드캄파니 아크티엔 게쩔샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쿠르트 내셀 보쉬, 한스 스튀클린, 에프. 호프만-라 롯슈 앤드캄파니 아크티엔 게쩔샤프트 filed Critical 쿠르트 내셀 보쉬, 한스 스튀클린
Publication of KR830004320A publication Critical patent/KR830004320A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

퀴나졸린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. a) 다음 구조식(Ⅱ)의 안트라닐산 유도체를 구조식(Ⅲ)의 2-할로티아졸과 함께 축합시키거나
    여기서 R은 수소 또는 저급알킬이고
    b) 다음 구조식(Ⅳ)의 화합물을 가수분해하거나
    여기서 R'는 저급알킬이고 R1은 메틸티오 또는 메틸설피닐이며
    c) 7-메틸티오-5-옥소-5H-티아졸로[2,3-b]퀴나졸린-2-카복실산을 산화하고
    d) 필요한 경우 수득된 화합물을 이들의 약학적으로 무독한 염으로 전환시켜 다음 구조식(I)의 퀴나졸린 유도체 및 이들의 약학적으로 무독한 염을 제조하는 방법.
    여기서 R1은 상기에서와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003887A 1979-10-12 1980-10-10 퀴나졸린 유도체의 제조방법 KR830004320A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/084,471 US4282360A (en) 1979-10-12 1979-10-12 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US84471 1998-05-22

Publications (1)

Publication Number Publication Date
KR830004320A true KR830004320A (ko) 1983-07-09

Family

ID=22185170

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003887A KR830004320A (ko) 1979-10-12 1980-10-10 퀴나졸린 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4282360A (ko)
EP (1) EP0027268A3 (ko)
JP (1) JPS5677288A (ko)
KR (1) KR830004320A (ko)
AU (1) AU6319080A (ko)
CA (1) CA1122216A (ko)
DK (1) DK426980A (ko)
ES (1) ES8201169A1 (ko)
FI (1) FI803214L (ko)
GR (1) GR70307B (ko)
HU (1) HU179391B (ko)
IL (1) IL61240A0 (ko)
MC (1) MC1356A1 (ko)
NO (1) NO803058L (ko)
PH (1) PH15743A (ko)
PT (1) PT71902B (ko)
ZA (1) ZA805920B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142727A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Thiazolo (2,3-b)-chinazolone, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des pflanzenwachstums
DE3142728A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Herbizide, enthaltend thiazolo(2,3-b)-chinazolone als wirkstoffe, und ihre verwendung zur beeinflussung des pflanzenwachstums
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4579132A (en) * 1983-02-04 1986-04-01 Windmere Corporation Flocked hair curling roller
EP0142057A3 (en) * 1983-11-04 1988-03-30 F. Hoffmann-La Roche Ag Thiazoloquinazoline derivatives, their preparation and pharmaceutical compositions containing same
US4738964A (en) * 1984-05-30 1988-04-19 Pennwalt Corporation Method of suppressing the immune system comprising administering 5H-thiazolo[2,3-b]quinazoline-3(2H)-one
US4588812A (en) * 1984-05-30 1986-05-13 Pennwalt Corporation Substituted 2,3-dihydro-5H-thiazolo[2,3,-b]quinazoline derivatives
DE3634532A1 (de) * 1986-10-10 1988-04-14 Basf Ag Verfahren zur herstellung von thiazolo-(2,3-b)chinazolonen
DE10046728C1 (de) * 2000-09-21 2001-09-27 Ibfb Gmbh Privates Inst Fuer B Tricyclische mercaptomethylsubstituierte 2,3-Dihydro-chinazolin-5-one und 2,3-Dihydro-benzo[1,2,4,]-thiadiazin-5,5-dioxide als Matrix Metalloproteinase (MMP) Inhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557425C2 (de) * 1975-12-19 1987-03-19 C.H. Boehringer Sohn, 6507 Ingelheim 11-Oxo-11-H-pyrido[2,1-b]-chinazolin-2-carbonsäure und ihre Salze, Verfahren zu ihrer Herstellung und Arzneimittel
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
US4168380A (en) * 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid

Also Published As

Publication number Publication date
HU179391B (en) 1982-10-28
DK426980A (da) 1981-04-13
CA1122216A (en) 1982-04-20
US4282360A (en) 1981-08-04
FI803214L (fi) 1981-04-13
PT71902A (en) 1980-10-31
ZA805920B (en) 1981-09-30
JPS5677288A (en) 1981-06-25
AU6319080A (en) 1981-04-16
IL61240A0 (en) 1980-12-31
PT71902B (en) 1982-03-31
GR70307B (ko) 1982-09-08
MC1356A1 (fr) 1981-08-10
EP0027268A2 (de) 1981-04-22
ES495865A0 (es) 1981-12-01
EP0027268A3 (de) 1981-06-17
NO803058L (no) 1981-04-13
ES8201169A1 (es) 1981-12-01
PH15743A (en) 1983-03-18

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