DE69900698T2 - In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren - Google Patents
In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von KrebstumorenInfo
- Publication number
- DE69900698T2 DE69900698T2 DE69900698T DE69900698T DE69900698T2 DE 69900698 T2 DE69900698 T2 DE 69900698T2 DE 69900698 T DE69900698 T DE 69900698T DE 69900698 T DE69900698 T DE 69900698T DE 69900698 T2 DE69900698 T2 DE 69900698T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- methylthiopropanoyl
- acid derivatives
- dimethylmercaptooctanoic
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9804041A FR2777001B1 (fr) | 1998-04-01 | 1998-04-01 | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69900698D1 DE69900698D1 (de) | 2002-02-21 |
DE69900698T2 true DE69900698T2 (de) | 2002-08-08 |
Family
ID=9524740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69900698T Expired - Fee Related DE69900698T2 (de) | 1998-04-01 | 1999-04-01 | In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren |
Country Status (11)
Country | Link |
---|---|
US (1) | US6117902A (de) |
EP (1) | EP0947503B1 (de) |
JP (1) | JP3459884B2 (de) |
AT (1) | ATE209184T1 (de) |
AU (1) | AU747867C (de) |
CA (1) | CA2264985C (de) |
DE (1) | DE69900698T2 (de) |
DK (1) | DK0947503T3 (de) |
ES (1) | ES2167989T3 (de) |
FR (1) | FR2777001B1 (de) |
PT (1) | PT947503E (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000020385A1 (fr) * | 1998-10-02 | 2000-04-13 | Sankyo Company, Limited | Derives de dithiol |
EP1486495B1 (de) * | 1998-10-26 | 2009-12-09 | The Research Foundation of State University of New York | Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten |
FR2809727B1 (fr) * | 2000-05-31 | 2002-07-26 | Galderma Res & Dev | Nouveaux composes aminothiolesters, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
US7078402B2 (en) * | 2000-05-31 | 2006-07-18 | Centre National De La Recherche Scientifique (Cnrs) | Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof |
US6916892B2 (en) * | 2001-12-03 | 2005-07-12 | Fina Technology, Inc. | Method for transitioning between Ziegler-Natta and metallocene catalysts in a bulk loop reactor for the production of polypropylene |
CN101765370B (zh) * | 2007-04-18 | 2014-06-25 | 基石制药公司 | 硫辛酸衍生物 |
US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
CA2684479C (en) * | 2007-04-18 | 2017-11-14 | Cornerstone Pharmaceuticals, Inc. | Amine salts of lipoic acid derivative and use thereof in the treatment of cancer |
KR20110025168A (ko) * | 2008-04-04 | 2011-03-09 | 로버트 쇼어 | 약학적 조성물 |
ES2819175T3 (es) | 2014-06-19 | 2021-04-15 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
CA2965898C (en) | 2014-06-19 | 2021-07-06 | Robert Shorr | Fatty acid analogs |
JP7062592B2 (ja) * | 2015-10-15 | 2022-05-06 | アドヴァンスト・バイオデザイン | アミノチオールエステル化合物またはその薬学的に許容される塩および対象の癌細胞におけるh2o2濃度を増大し得る化合物の組み合わせ |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2728790B1 (fr) * | 1994-12-29 | 1997-01-24 | Cird Galderma | Composition modulant l'apoptose comprenant du methonial ou tout facteur influencant le taux intracellulaire de methonial |
-
1998
- 1998-04-01 FR FR9804041A patent/FR2777001B1/fr not_active Expired - Lifetime
-
1999
- 1999-03-30 US US09/281,654 patent/US6117902A/en not_active Expired - Fee Related
- 1999-03-31 CA CA002264985A patent/CA2264985C/fr not_active Expired - Fee Related
- 1999-03-31 AU AU22536/99A patent/AU747867C/en not_active Ceased
- 1999-04-01 EP EP99400803A patent/EP0947503B1/de not_active Expired - Lifetime
- 1999-04-01 AT AT99400803T patent/ATE209184T1/de not_active IP Right Cessation
- 1999-04-01 DE DE69900698T patent/DE69900698T2/de not_active Expired - Fee Related
- 1999-04-01 PT PT99400803T patent/PT947503E/pt unknown
- 1999-04-01 DK DK99400803T patent/DK0947503T3/da active
- 1999-04-01 ES ES99400803T patent/ES2167989T3/es not_active Expired - Lifetime
- 1999-04-01 JP JP09556099A patent/JP3459884B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0947503T3 (da) | 2002-05-13 |
FR2777001B1 (fr) | 2000-06-09 |
FR2777001A1 (fr) | 1999-10-08 |
JP2000001471A (ja) | 2000-01-07 |
ATE209184T1 (de) | 2001-12-15 |
ES2167989T3 (es) | 2002-05-16 |
US6117902A (en) | 2000-09-12 |
AU2253699A (en) | 1999-10-14 |
CA2264985C (fr) | 2003-12-09 |
EP0947503A1 (de) | 1999-10-06 |
AU747867C (en) | 2003-01-09 |
JP3459884B2 (ja) | 2003-10-27 |
PT947503E (pt) | 2002-05-31 |
EP0947503B1 (de) | 2001-11-21 |
AU747867B2 (en) | 2002-05-23 |
CA2264985A1 (fr) | 1999-10-01 |
DE69900698D1 (de) | 2002-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |