GR3034023T3 - Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. - Google Patents

Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.

Info

Publication number
GR3034023T3
GR3034023T3 GR20000401711T GR20000401711T GR3034023T3 GR 3034023 T3 GR3034023 T3 GR 3034023T3 GR 20000401711 T GR20000401711 T GR 20000401711T GR 20000401711 T GR20000401711 T GR 20000401711T GR 3034023 T3 GR3034023 T3 GR 3034023T3
Authority
GR
Greece
Prior art keywords
group
carbon atoms
salts
preparation
isoxazole
Prior art date
Application number
GR20000401711T
Other languages
Greek (el)
Inventor
Elizabeth Anne Kuo
Robert Westwood
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of GR3034023T3 publication Critical patent/GR3034023T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds of formula (I): <IMAGE> [in which R1 represents a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; R2 represents a cycloalkyl group containing 3 to 6 carbon atoms; R4 represents a halogen atom, a nitrile group, a nitro group, an -SCH3 group, a C1-6 alkylcarbonyl group, a C3-6 cycloalkylcarbonyl group, a -CX3 group, a -WCX3 group, a -(CH2)nCX3 group, a -(CX2)n CX3 group, a -W(CX2)nCX3 group or a -W(CH2)nCX3 group, in which X represents a halogen atom, W represents an oxygen or sulphur atom and n represents 1, 2 or 3; and R5 represents a hydrogen atom, an alkyl group containing 1 to 3 carbon atoms or a cycloalkyl group containing 3 to 6 carbon atoms; provided that, if R5 represents a hydrogen atom, R4 does not represent an -SCH3 or -CF3 group]; and their salts have an anti-proliferative, anti-inflammatory and anti-tumour activity. A description is also given of processes for their preparation, of the compositions which contain them and of their use in therapeutics.
GR20000401711T 1993-10-01 2000-07-26 Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. GR3034023T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939320299A GB9320299D0 (en) 1993-10-01 1993-10-01 Isoxazole derivatives

Publications (1)

Publication Number Publication Date
GR3034023T3 true GR3034023T3 (en) 2000-11-30

Family

ID=10742865

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000401711T GR3034023T3 (en) 1993-10-01 2000-07-26 Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.

Country Status (11)

Country Link
US (2) US5476866A (en)
EP (1) EP0646578B1 (en)
JP (1) JP3723589B2 (en)
AT (1) ATE193531T1 (en)
CA (1) CA2133140C (en)
DE (1) DE69424734T2 (en)
DK (1) DK0646578T3 (en)
ES (1) ES2146643T3 (en)
GB (1) GB9320299D0 (en)
GR (1) GR3034023T3 (en)
PT (1) PT646578E (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
DE19539638A1 (en) * 1995-10-25 1997-04-30 Hoechst Ag The use of isoxazole and crotonic acid amide derivatives for the treatment of cancer
AU7687998A (en) * 1997-05-19 1998-12-11 Sugen, Inc. Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
ATE196764T1 (en) * 1997-08-08 2000-10-15 Aventis Pharma Gmbh CRYSTAL FORM OF 5-METHYLISOXAZOLE-4-CARBONIC ACID (4-TRIFLUORMETHYL) ANILIDE
US6579880B2 (en) 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
WO2002007783A2 (en) * 2000-07-20 2002-01-31 Regents Of The University Of Minnesota Radiolabeled immunotoxins
MXPA04000224A (en) 2001-07-10 2005-07-25 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
KR20030063046A (en) * 2002-01-22 2003-07-28 주식회사 엘지생명과학 LB84068-Containing composition for prevention and treatment of inflammatory diseases and formulation containing thereof
BR0317687A (en) 2002-12-23 2005-11-22 4Sc Ag Aromatic compounds as antiinflammatory, immunomodulatory and antiproliferative agents
UA108760C2 (en) 2010-07-01 2015-06-10 Calcium salts of the compound as anti-inflammatory, immunomodulatory and antiproliferative agents
KR20160079123A (en) 2013-11-22 2016-07-05 젠자임 코포레이션 Novel methods for treating neurodegenerative diseases
IL307422A (en) 2018-03-16 2023-12-01 Immunic Ag Calcium salt polymorph inhibitors of dihydroorotate dehydrogenase and processes for preparing same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178596C (en) * 1975-06-05 1986-04-16 Hoechst Ag METHOD FOR PREPARING A MEDICINAL PRODUCT WITH ANTIFLOGISTIC AND / OR ANALGETIC ACTION, AND A METHOD FOR PREPARING THEIR PRODUCT TO BE USED AS MEDICINAL COMPOUNDS 5-METHYLISOXAZOLE-4-CARBONIC ACID.
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
GB9209330D0 (en) * 1992-04-30 1992-06-17 Roussel Lab Ltd Chemical compounds

Also Published As

Publication number Publication date
ES2146643T3 (en) 2000-08-16
DK0646578T3 (en) 2000-10-30
US5506249A (en) 1996-04-09
JP3723589B2 (en) 2005-12-07
EP0646578A1 (en) 1995-04-05
CA2133140A1 (en) 1995-04-02
JPH07149743A (en) 1995-06-13
CA2133140C (en) 2006-07-25
ATE193531T1 (en) 2000-06-15
DE69424734T2 (en) 2000-11-16
US5476866A (en) 1995-12-19
DE69424734D1 (en) 2000-07-06
PT646578E (en) 2000-09-29
GB9320299D0 (en) 1993-11-17
EP0646578B1 (en) 2000-05-31

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