DE69900698D1 - In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren - Google Patents

In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren

Info

Publication number
DE69900698D1
DE69900698D1 DE69900698T DE69900698T DE69900698D1 DE 69900698 D1 DE69900698 D1 DE 69900698D1 DE 69900698 T DE69900698 T DE 69900698T DE 69900698 T DE69900698 T DE 69900698T DE 69900698 D1 DE69900698 D1 DE 69900698D1
Authority
DE
Germany
Prior art keywords
substituted
methylthiopropanoyl
acid derivatives
dimethylmercaptooctanoic
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69900698T
Other languages
English (en)
Other versions
DE69900698T2 (de
Inventor
Gerard Anthony Quash
Jacques Gore
Guy Fournet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Application granted granted Critical
Publication of DE69900698D1 publication Critical patent/DE69900698D1/de
Publication of DE69900698T2 publication Critical patent/DE69900698T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
DE69900698T 1998-04-01 1999-04-01 In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren Expired - Fee Related DE69900698T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804041A FR2777001B1 (fr) 1998-04-01 1998-04-01 Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses

Publications (2)

Publication Number Publication Date
DE69900698D1 true DE69900698D1 (de) 2002-02-21
DE69900698T2 DE69900698T2 (de) 2002-08-08

Family

ID=9524740

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69900698T Expired - Fee Related DE69900698T2 (de) 1998-04-01 1999-04-01 In 6-S und/oder 8-S durch 3-Methylthiopropanoylrest substituierte 6,8-Dimethylmercaptooctansäure-Derivate und pharmaceutische Zubereitungen zur Behandlung von Krebstumoren

Country Status (11)

Country Link
US (1) US6117902A (de)
EP (1) EP0947503B1 (de)
JP (1) JP3459884B2 (de)
AT (1) ATE209184T1 (de)
AU (1) AU747867C (de)
CA (1) CA2264985C (de)
DE (1) DE69900698T2 (de)
DK (1) DK0947503T3 (de)
ES (1) ES2167989T3 (de)
FR (1) FR2777001B1 (de)
PT (1) PT947503E (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6001299A (en) * 1998-10-02 2000-04-26 Sankyo Company Limited Dithiol derivatives
IL142824A0 (en) * 1998-10-26 2002-03-10 Univ New York State Res Found Lipoic acid derivatives and their use in treatment of disease
FR2809727B1 (fr) * 2000-05-31 2002-07-26 Galderma Res & Dev Nouveaux composes aminothiolesters, compositions pharmaceutiques et cosmetiques les contenant et utilisations
US7078402B2 (en) * 2000-05-31 2006-07-18 Centre National De La Recherche Scientifique (Cnrs) Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof
US6916892B2 (en) * 2001-12-03 2005-07-12 Fina Technology, Inc. Method for transitioning between Ziegler-Natta and metallocene catalysts in a bulk loop reactor for the production of polypropylene
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
NZ580973A (en) * 2007-04-18 2011-10-28 Cornerstone Pharmaceuticals Inc Pharmaceutical formulations containing lipoic acid derivatives
EP2695614B1 (de) * 2007-04-18 2017-07-05 Cornerstone Pharmaceuticals, Inc. Liponsäurederivate
WO2009123597A1 (en) * 2008-04-04 2009-10-08 Robert Shorr Pharmaceutical composition
WO2015195070A1 (en) 2014-06-19 2015-12-23 Robert Shorr Pharmaceutical compounds
EP3188726B1 (de) 2014-06-19 2019-08-07 Rafael Pharmaceuticals, Inc. Pharmazeutische verbindungen
DK3362094T3 (da) * 2015-10-15 2021-03-01 Advanced Biodesign Kombination omfattende en aminothiolesterforbindelse eller et farmaceutisk acceptabelt salt deraf og en forbindelse, der er i stand til at øge H2O2-niveauet i cancerceller i et individ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2728790B1 (fr) * 1994-12-29 1997-01-24 Cird Galderma Composition modulant l'apoptose comprenant du methonial ou tout facteur influencant le taux intracellulaire de methonial

Also Published As

Publication number Publication date
EP0947503B1 (de) 2001-11-21
ATE209184T1 (de) 2001-12-15
US6117902A (en) 2000-09-12
AU747867C (en) 2003-01-09
JP2000001471A (ja) 2000-01-07
CA2264985A1 (fr) 1999-10-01
AU747867B2 (en) 2002-05-23
PT947503E (pt) 2002-05-31
DE69900698T2 (de) 2002-08-08
FR2777001B1 (fr) 2000-06-09
DK0947503T3 (da) 2002-05-13
AU2253699A (en) 1999-10-14
EP0947503A1 (de) 1999-10-06
CA2264985C (fr) 2003-12-09
FR2777001A1 (fr) 1999-10-08
ES2167989T3 (es) 2002-05-16
JP3459884B2 (ja) 2003-10-27

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee