ES2059669T3 - Un metodo para preparar (2r, 3s, 4s)-alfa-(carboxiciclopropil)-glicina. - Google Patents

Un metodo para preparar (2r, 3s, 4s)-alfa-(carboxiciclopropil)-glicina.

Info

Publication number
ES2059669T3
ES2059669T3 ES89119266T ES89119266T ES2059669T3 ES 2059669 T3 ES2059669 T3 ES 2059669T3 ES 89119266 T ES89119266 T ES 89119266T ES 89119266 T ES89119266 T ES 89119266T ES 2059669 T3 ES2059669 T3 ES 2059669T3
Authority
ES
Spain
Prior art keywords
glycine
alpha
carboxiciclopropil
prepare
carboxycyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89119266T
Other languages
English (en)
Inventor
Yasufumi Ohfune
Keiko Shimamoto
Haruhiko Shinozaki
Michiko Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2059669T3 publication Critical patent/ES2059669T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE FORMULA (I) Y LAS SALES DEL MISMO. EL COMPUESTO (I) EXHIBE ACTIVIDAD DE DEPOLARIZACION MAS POTENTE ENTRE LOS COMPETIDORES DEL NMDA CONOCIDOS Y CONSTITUYE UNA HERRAMIENTA UTIL PARA INVESTIGAR VARIAS FUNCIONES NEURONALES RELACIONADAS CON LOS RECEPTORES DEL ACIDO AMINO EXCITATORIOS.
ES89119266T 1988-10-17 1989-10-17 Un metodo para preparar (2r, 3s, 4s)-alfa-(carboxiciclopropil)-glicina. Expired - Lifetime ES2059669T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63261155A JP2757960B2 (ja) 1988-10-17 1988-10-17 （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン

Publications (1)

Publication Number Publication Date
ES2059669T3 true ES2059669T3 (es) 1994-11-16

Family

ID=17357874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89119266T Expired - Lifetime ES2059669T3 (es) 1988-10-17 1989-10-17 Un metodo para preparar (2r, 3s, 4s)-alfa-(carboxiciclopropil)-glicina.

Country Status (6)

Country Link
US (1) US5068412A (es)
EP (1) EP0363994B1 (es)
JP (1) JP2757960B2 (es)
AT (1) ATE94867T1 (es)
DE (1) DE68909362T2 (es)
ES (1) ES2059669T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505908A (ja) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Ｎｍｄａ受容体のアロステリックモジュレーター
US5717109A (en) * 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2199508A1 (en) * 1994-09-08 1996-03-14 Darryle Darwin Schoepp Excitatory amino acid receptor antagonists
IT1276153B1 (it) * 1995-11-17 1997-10-27 Roberto Pellicciari Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato
US6361957B1 (en) * 1999-08-03 2002-03-26 Glytech, Inc. Assay for D-serine transport antagonist and use for treating psychosis
WO1997020553A1 (en) * 1995-12-07 1997-06-12 Javitt Daniel C Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists
US6355681B2 (en) * 1995-12-07 2002-03-12 Glytech, Inc. Glycine substitutes and precursors for treating a psychosis
JPH1053521A (ja) * 1996-08-12 1998-02-24 Kagaku Gijutsu Shinko Jigyodan 脳内グルタミン酸の活性抑制剤および活性増強剤
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine
US6750364B2 (en) 2001-06-29 2004-06-15 Wyeth Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport
US6689905B2 (en) 2001-06-29 2004-02-10 Wyeth Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid
US6689904B2 (en) 2001-06-29 2004-02-10 Wyeth Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine
US7232798B2 (en) * 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
AU2019271189A1 (en) 2018-05-15 2021-01-07 Lloyd Hung Loi TRAN Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305177C (en) * 1987-06-30 1992-07-14 Yasufumi Ohfune Carboxycyclopropylglycine and process for producing the same

Also Published As

Publication number Publication date
JP2757960B2 (ja) 1998-05-25
DE68909362D1 (de) 1993-10-28
DE68909362T2 (de) 1994-03-10
JPH02108654A (ja) 1990-04-20
EP0363994A3 (en) 1991-03-27
EP0363994A2 (en) 1990-04-18
US5068412A (en) 1991-11-26
ATE94867T1 (de) 1993-10-15
EP0363994B1 (en) 1993-09-22

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