ATE94867T1 - (2r,3s,4s)-alpha-(carboxycyclopropyl)glycin. - Google Patents

(2r,3s,4s)-alpha-(carboxycyclopropyl)glycin.

Info

Publication number
ATE94867T1
ATE94867T1 AT89119266T AT89119266T ATE94867T1 AT E94867 T1 ATE94867 T1 AT E94867T1 AT 89119266 T AT89119266 T AT 89119266T AT 89119266 T AT89119266 T AT 89119266T AT E94867 T1 ATE94867 T1 AT E94867T1
Authority
AT
Austria
Prior art keywords
carboxycyclopropyl
glycine
alpha
depolarizing
potent
Prior art date
Application number
AT89119266T
Other languages
English (en)
Inventor
Yasufumi Ohfune
Keiko Shimamoto
Haruhiko Shinozaki
Michiko Ishida
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ATE94867T1 publication Critical patent/ATE94867T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89119266T 1988-10-17 1989-10-17 (2r,3s,4s)-alpha-(carboxycyclopropyl)glycin. ATE94867T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63261155A JP2757960B2 (ja) 1988-10-17 1988-10-17 （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン
EP89119266A EP0363994B1 (de) 1988-10-17 1989-10-17 (2R,3S,4S)-Alpha-(carboxycyclopropyl)glycin

Publications (1)

Publication Number Publication Date
ATE94867T1 true ATE94867T1 (de) 1993-10-15

Family

ID=17357874

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89119266T ATE94867T1 (de) 1988-10-17 1989-10-17 (2r,3s,4s)-alpha-(carboxycyclopropyl)glycin.

Country Status (6)

Country Link
US (1) US5068412A (de)
EP (1) EP0363994B1 (de)
JP (1) JP2757960B2 (de)
AT (1) ATE94867T1 (de)
DE (1) DE68909362T2 (de)
ES (1) ES2059669T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505908A (ja) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Ｎｍｄａ受容体のアロステリックモジュレーター
US5717109A (en) * 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
DE69513832T2 (de) * 1994-09-08 2000-04-13 Lilly Co Eli Exzitatorische aminosäure-rezeptor-antagonisten
IT1276153B1 (it) * 1995-11-17 1997-10-27 Roberto Pellicciari Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato
WO1997020552A1 (en) * 1995-12-07 1997-06-12 Albert Einstein College Of Medicine Of Yeshiva University Treatment of negative and cognitive symptoms of schizophrenia with glycine and its precursors
US6361957B1 (en) * 1999-08-03 2002-03-26 Glytech, Inc. Assay for D-serine transport antagonist and use for treating psychosis
US6355681B2 (en) * 1995-12-07 2002-03-12 Glytech, Inc. Glycine substitutes and precursors for treating a psychosis
JPH1053521A (ja) * 1996-08-12 1998-02-24 Kagaku Gijutsu Shinko Jigyodan 脳内グルタミン酸の活性抑制剤および活性増強剤
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine
US6750364B2 (en) 2001-06-29 2004-06-15 Wyeth Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport
US6689904B2 (en) 2001-06-29 2004-02-10 Wyeth Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine
US6689905B2 (en) 2001-06-29 2004-02-10 Wyeth Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid
US7232798B2 (en) * 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
AU2019271189A1 (en) 2018-05-15 2021-01-07 Lloyd Hung Loi TRAN Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305177C (en) * 1987-06-30 1992-07-14 Yasufumi Ohfune Carboxycyclopropylglycine and process for producing the same

Also Published As

Publication number Publication date
EP0363994A2 (de) 1990-04-18
EP0363994A3 (de) 1991-03-27
JP2757960B2 (ja) 1998-05-25
ES2059669T3 (es) 1994-11-16
DE68909362T2 (de) 1994-03-10
US5068412A (en) 1991-11-26
DE68909362D1 (de) 1993-10-28
JPH02108654A (ja) 1990-04-20
EP0363994B1 (de) 1993-09-22

Similar Documents

Publication Publication Date Title
ATE94867T1 (de) (2r,3s,4s)-alpha-(carboxycyclopropyl)glycin.
AU634294B2 (en) Fibrinogen receptor antagonists
AU7166787A (en) Antagonists of specific excitatory amino acid neurotransmitter receptors
DE69010139D1 (de) Haarkräftigungsmittel.
EP1486207A3 (de) Sulfonierte Aminosäurederivate und diese enthaltende Metalloproteinaseinhibitoren
ES514664A0 (es) "un procedimiento para la preparacion de derivados de aminoacidos utiles como agentes antihipertensores".
ATE189387T1 (de) Darreichungsformen enthaltend feste salze von r- thioctsäure mit verbesserter freisetzung und bioverfügbarkeit
AU644380B2 (en) Fibrinogen receptor antagonists
GR3017792T3 (en) Excitatory amino acid antagonists.
DK232989D0 (da) Antiviralt praeparat
ES2088995T3 (es) Utilizacion de complejos de cobre de alfa amino acidos que contienen grupos amino terminales como suplemento nutritivo.
AU5491490A (en) Excitatory amino acid antagonists
CA2087091A1 (en) Excitatory amino acid antagonists
DE3381850D1 (de) Pharmazeutische zusammensetzung.
TR199902043T2 (xx) Sabit, higroskopik olmayan (-) karnitin tuzlar�n� haz�rlama y�ntemi.
MC2107A1 (fr) Derives d'acides amines
PT91045A (pt) Processo para a preparacao de derivados aminodiol n-terminais etereos de amino--acidos, uteis como agentes anti-hipertensivos
ES2064577T3 (es) N-azabiciclo(3.3.0)octanoamidas de acidos aromaticos.
IT1299623B1 (it) Composizione per uso cosmetico o farmaceutico a base di acido lipoico e acido piruvico
UA26981A1 (uk) Гербіцидhа композиція
BG50331A1 (en) Herbicide and the method for its preparation

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time