IT1125469B - Composto 2-metil-diidropirindinico,procedimenti per la sua preparazione e composizione farmaceutica che lo comprende - Google Patents
Composto 2-metil-diidropirindinico,procedimenti per la sua preparazione e composizione farmaceutica che lo comprendeInfo
- Publication number
- IT1125469B IT1125469B IT26362/79A IT2636279A IT1125469B IT 1125469 B IT1125469 B IT 1125469B IT 26362/79 A IT26362/79 A IT 26362/79A IT 2636279 A IT2636279 A IT 2636279A IT 1125469 B IT1125469 B IT 1125469B
- Authority
- IT
- Italy
- Prior art keywords
- dihydropyrindinic
- procedures
- methyl
- compound
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7839978 | 1978-10-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7926362A0 IT7926362A0 (it) | 1979-10-09 |
| IT1125469B true IT1125469B (it) | 1986-05-14 |
Family
ID=10500226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT26362/79A IT1125469B (it) | 1978-10-10 | 1979-10-09 | Composto 2-metil-diidropirindinico,procedimenti per la sua preparazione e composizione farmaceutica che lo comprende |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JPS5562065A (fr) |
| BE (1) | BE879263A (fr) |
| CA (1) | CA1117117A (fr) |
| CH (1) | CH642353A5 (fr) |
| DE (1) | DE2940833A1 (fr) |
| FR (1) | FR2438654A1 (fr) |
| GB (1) | GB2036722B (fr) |
| IT (1) | IT1125469B (fr) |
| NL (1) | NL7907482A (fr) |
| SE (2) | SE446265B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| JPS57175164A (en) * | 1981-04-18 | 1982-10-28 | Banyu Pharmaceut Co Ltd | 1,4-dihydropyridine derivative and its preparation |
| EP0080220B1 (fr) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, leur procédé de préparation, leurs compositions et leur application comme médicaments |
| ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
| CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| DE3312216A1 (de) * | 1983-04-05 | 1984-10-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern |
| JPS6038322A (ja) * | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンａ物質含有易溶性固形製剤 |
| GB8412208D0 (en) * | 1984-05-12 | 1984-06-20 | Pfizer Ltd | Quinolone inotropic agents |
| GB8431119D0 (en) * | 1984-12-10 | 1985-01-16 | Fujisawa Pharmaceutical Co | Anti-arteriosclerotic composition |
| GB8602518D0 (en) * | 1986-02-01 | 1986-03-05 | Wyeth John & Brother Ltd | 1 4-dihydropyridines |
| JPS63115890A (ja) * | 1986-10-31 | 1988-05-20 | Nippon Shinyaku Co Ltd | ２位置換１，４−ジヒドロピリジン誘導体 |
| US5114946A (en) * | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| DE3877630T2 (de) * | 1987-06-12 | 1993-06-03 | American Cyanamid Co | Transkutane verabreichung von pharmazeutika. |
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| CA1318596C (fr) * | 1987-12-29 | 1993-06-01 | Takaharu Ono | Agent de suppression de l'hypertrophie cardiaque et d'amelioration de l'elasticite du reseau veineux, contenant un compose du type dihydropyridine |
| EP0322747B1 (fr) * | 1987-12-29 | 1994-03-02 | Fujisawa Pharmaceutical Co., Ltd. | Agent protégeant les neurones cérébraux contenant un dérivé de la dihydropyridine |
| JP2007230869A (ja) * | 2004-04-05 | 2007-09-13 | Takeda Chem Ind Ltd | アルドステロン受容体拮抗剤 |
| CN103951608B (zh) * | 2009-08-04 | 2016-04-27 | 喜德生（苏州）医药科技有限公司 | 尼伐地平晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
| GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
| DE2658183A1 (de) * | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
-
1979
- 1979-09-21 CA CA000336130A patent/CA1117117A/fr not_active Expired
- 1979-10-08 FR FR7925007A patent/FR2438654A1/fr active Granted
- 1979-10-08 BE BE0/197526A patent/BE879263A/fr not_active IP Right Cessation
- 1979-10-09 SE SE7908367A patent/SE446265B/sv not_active IP Right Cessation
- 1979-10-09 GB GB7935022A patent/GB2036722B/en not_active Expired
- 1979-10-09 JP JP13053079A patent/JPS5562065A/ja active Granted
- 1979-10-09 NL NL7907482A patent/NL7907482A/nl active Search and Examination
- 1979-10-09 DE DE19792940833 patent/DE2940833A1/de active Granted
- 1979-10-09 IT IT26362/79A patent/IT1125469B/it active Protection Beyond IP Right Term
- 1979-10-10 CH CH912879A patent/CH642353A5/de not_active IP Right Cessation
-
1984
- 1984-02-09 SE SE8400689A patent/SE446096B/sv not_active IP Right Cessation
-
1985
- 1985-09-26 JP JP60214152A patent/JPS61118366A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE8400689D0 (sv) | 1984-02-09 |
| JPS5562065A (en) | 1980-05-10 |
| GB2036722A (en) | 1980-07-02 |
| DE2940833C2 (fr) | 1989-01-26 |
| JPS6143343B2 (fr) | 1986-09-26 |
| GB2036722B (en) | 1982-12-01 |
| SE446096B (sv) | 1986-08-11 |
| CH642353A5 (de) | 1984-04-13 |
| FR2438654B1 (fr) | 1983-01-14 |
| DE2940833A1 (de) | 1980-04-30 |
| FR2438654A1 (fr) | 1980-05-09 |
| JPS61118366A (ja) | 1986-06-05 |
| NL7907482A (nl) | 1980-04-14 |
| SE446265B (sv) | 1986-08-25 |
| IT7926362A0 (it) | 1979-10-09 |
| BE879263A (fr) | 1980-04-08 |
| CA1117117A (fr) | 1982-01-26 |
| SE8400689L (sv) | 1984-02-09 |
| SE7908367L (sv) | 1980-04-11 |
| JPS6125711B2 (fr) | 1986-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 555, 19961120; FUJISAWA PHARMACEUTICAL CO., LDT. |
|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971030 |