FR2424924A1 - Nouvelles azolopyrimidinones, leur procede de production et medicament les contenant - Google Patents
Nouvelles azolopyrimidinones, leur procede de production et medicament les contenantInfo
- Publication number
- FR2424924A1 FR2424924A1 FR7911351A FR7911351A FR2424924A1 FR 2424924 A1 FR2424924 A1 FR 2424924A1 FR 7911351 A FR7911351 A FR 7911351A FR 7911351 A FR7911351 A FR 7911351A FR 2424924 A1 FR2424924 A1 FR 2424924A1
- Authority
- FR
- France
- Prior art keywords
- exercise
- azolopyrimidinones
- new
- production process
- product containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE MEDICALE. ELLE CONCERNE DES 6-(1H-TETRAZOL-5-YL)THIAZOLO(3,2-A)-PYRIMIDINE - 5 - ONES, DES 3 - (1H - TETRAZOL - 5 - YL) - 4H - PYRIMIDO(2,1,B) - BENZOTHIAZOLE - 4 - ONES ET LES IMIDAZO- ET TRIAZOLOPYRIMIDINES, LES THIONES ET LES IMINES CORRESPONDANTES. LES COMPOSES DE L'INVENTION SONT UTILES COMME COMPOSES ANTI-ALLERGIQUES ET ANTI-ASTHMATIQUES DU FAIT DE L'ACTION INHIBITRICE QU'ILS EXERCENT SUR LA REACTION D'HYPERSENSIBILITE IMMEDIATE CHEZ LES MAMMIFERES ET DE L'ACTION DE RELAXATION QU'ILS EXERCENT SUR LE MUSCLE DE LA TRACHEE. DES COMPOSES INTERMEDIAIRES DE LA SYNTHESE DE CES SUBSTANCES A PARTIR DE 2-AMINOAZOLES ET D'ETHOXYMETHYLENEMALONONITRILE EXERCENT EGALEMENT UNE ACTIVITE DE RELAXATION DU MUSCLE LISSE ET D'INHIBITION DE LA REACTION D'HYPERSENSIBILITE IMMEDIATE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/903,265 US4223031A (en) | 1978-05-05 | 1978-05-05 | Azolopyrimidinones |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2424924A1 true FR2424924A1 (fr) | 1979-11-30 |
FR2424924B1 FR2424924B1 (fr) | 1983-01-14 |
Family
ID=25417203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7911351A Granted FR2424924A1 (fr) | 1978-05-05 | 1979-05-04 | Nouvelles azolopyrimidinones, leur procede de production et medicament les contenant |
Country Status (18)
Country | Link |
---|---|
US (1) | US4223031A (fr) |
JP (1) | JPS54145696A (fr) |
AU (1) | AU528715B2 (fr) |
BE (1) | BE876059A (fr) |
CA (1) | CA1109870A (fr) |
CH (2) | CH641460A5 (fr) |
DE (1) | DE2918085A1 (fr) |
DK (1) | DK185079A (fr) |
FI (1) | FI65260C (fr) |
FR (1) | FR2424924A1 (fr) |
GB (1) | GB2020654B (fr) |
GR (1) | GR72717B (fr) |
IE (1) | IE47976B1 (fr) |
LU (1) | LU81231A1 (fr) |
NL (1) | NL7903535A (fr) |
SE (2) | SE445642B (fr) |
YU (1) | YU103679A (fr) |
ZA (1) | ZA792130B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4491587A (en) * | 1978-05-05 | 1985-01-01 | Mead Johnson & Company | Tetrazole derivatives |
US4297355A (en) * | 1979-11-15 | 1981-10-27 | Schering Corporation | (1H,3H,5H)-(1)-Benzopyrano-(2,3-d)-pyrimidine-4-one-2-thiones and their use as anti-allergy agents |
DK151811C (da) * | 1979-11-23 | 1988-06-06 | Pfizer | Analogifremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolooe3,2-aaa-pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt 1-oxo-1h-thiazolooe3,2-aaapyrimidin-2-carboxylsyrer til anvendelse som udgangsmaterialer ved fremgangsmaaden |
US4414388A (en) * | 1979-11-23 | 1983-11-08 | Pfizer Inc. | 1-Oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides |
JPS57165318A (en) * | 1981-04-03 | 1982-10-12 | Mochida Pharmaceut Co Ltd | Remedy for asthma |
US4510143A (en) * | 1982-02-17 | 1985-04-09 | Roussel Uclaf | Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives |
IL69417A (en) * | 1982-08-27 | 1987-12-20 | Roussel Uclaf | 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them |
US4476130A (en) * | 1982-09-09 | 1984-10-09 | Riker Laboratories, Inc. | 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity |
US4474953A (en) * | 1982-09-09 | 1984-10-02 | Riker Laboratories, Inc. | Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones |
US4507477A (en) * | 1982-09-09 | 1985-03-26 | Riker Laboratories, Inc. | Process for tetrazolyl-pyrimidinone derivatives |
GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
GB8334210D0 (en) * | 1983-12-22 | 1984-02-01 | Roussel Lab Ltd | Imidazo(1 2-c)pyrimidines |
US4762840A (en) * | 1984-02-13 | 1988-08-09 | Roussel Uclaf | Pyrimido[2,1-b]benzothiazoles having antiallergic activity |
JPS60226887A (ja) * | 1984-04-25 | 1985-11-12 | Dai Ichi Seiyaku Co Ltd | トリアゾロピリミジン誘導体 |
GB8422916D0 (en) * | 1984-09-11 | 1984-10-17 | May & Baker Ltd | Compositions of matter |
GB8422918D0 (en) * | 1984-09-11 | 1984-10-17 | May & Baker Ltd | Compositions of matter |
CA1270840A (fr) * | 1985-01-29 | 1990-06-26 | Wolfgang Wehner | Derives du triazole et leur utilisation pour stabiliser les polymeres organiques |
IL78017A (en) * | 1986-03-03 | 1989-06-30 | Yissum Res Dev Co | Sustained release tablets of theophylline |
JPS6357522A (ja) * | 1986-08-28 | 1988-03-12 | Mect Corp | ピリミド〔2,1−d〕ベンゾチアゾ−ル誘導体からなる血小板凝集抑制剤 |
IL85207A (en) * | 1987-02-06 | 1992-06-21 | Daiichi Seiyaku Co | 6-substituted thiazolo-(and 1,3,4-thiadiazolo-)(3,2-a)-(1,2,3)triazolo(4,5-d)pyrimidin-9(1h)-ones and their preparation |
EP2229388A4 (fr) * | 2008-01-11 | 2012-03-07 | Glenmark Pharmaceuticals Sa | Dérivés de pyrimidine condensée en tant que modulateurs de trpv3 |
US8119647B2 (en) | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1070243A (en) * | 1964-07-15 | 1967-06-01 | Smith Kline French Lab | S-triazolopyrimidones, their preparation and compositions containing them |
GB1209629A (en) * | 1966-11-29 | 1970-10-21 | Ciba Ltd | Novel pyrimido-benzthiazole and -benzoxazole compounds, process for their manufacture, and compositions containing them |
US3907799A (en) * | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
FR2335229A1 (fr) * | 1975-12-19 | 1977-07-15 | Boehringer Sohn Ingelheim | Nouveaux derives de quinazolone, leur preparation et leur utilisation en tant que medicaments |
FR2401159A1 (fr) * | 1977-05-25 | 1979-03-23 | Bristol Myers Co | Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE33549B1 (en) * | 1968-09-13 | 1974-08-07 | Ici Ltd | S-triazolo (1,5-a) pyrimidine derivatives |
US3888983A (en) * | 1970-08-14 | 1975-06-10 | Seperic | Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia |
US4033961A (en) * | 1975-10-07 | 1977-07-05 | Warner-Lambert Company | Pyrido[2-1-b]quinazolin-ones and their methods of preparation |
US4041163A (en) * | 1976-03-29 | 1977-08-09 | Pfizer Inc. | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents |
US4072679A (en) * | 1976-06-15 | 1978-02-07 | E. R. Squibb & Sons, Inc. | 1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides |
-
1978
- 1978-05-05 US US05/903,265 patent/US4223031A/en not_active Expired - Lifetime
-
1979
- 1979-05-01 GB GB7915178A patent/GB2020654B/en not_active Expired
- 1979-05-02 FI FI791411A patent/FI65260C/fi not_active IP Right Cessation
- 1979-05-02 AU AU46667/79A patent/AU528715B2/en not_active Ceased
- 1979-05-03 YU YU01036/79A patent/YU103679A/xx unknown
- 1979-05-03 ZA ZA792130A patent/ZA792130B/xx unknown
- 1979-05-04 DK DK185079A patent/DK185079A/da not_active Application Discontinuation
- 1979-05-04 GR GR59006A patent/GR72717B/el unknown
- 1979-05-04 NL NL7903535A patent/NL7903535A/xx not_active Application Discontinuation
- 1979-05-04 DE DE19792918085 patent/DE2918085A1/de not_active Withdrawn
- 1979-05-04 CA CA326,912A patent/CA1109870A/fr not_active Expired
- 1979-05-04 BE BE0/195011A patent/BE876059A/fr not_active IP Right Cessation
- 1979-05-04 FR FR7911351A patent/FR2424924A1/fr active Granted
- 1979-05-04 SE SE7903927A patent/SE445642B/sv unknown
- 1979-05-04 JP JP5414279A patent/JPS54145696A/ja active Pending
- 1979-05-07 CH CH426779A patent/CH641460A5/de not_active IP Right Cessation
- 1979-05-07 CH CH597/84A patent/CH651300A5/de not_active IP Right Cessation
- 1979-05-07 LU LU81231A patent/LU81231A1/fr unknown
- 1979-08-08 IE IE912/79A patent/IE47976B1/en unknown
-
1984
- 1984-08-20 SE SE8404151A patent/SE8404151D0/xx not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1070243A (en) * | 1964-07-15 | 1967-06-01 | Smith Kline French Lab | S-triazolopyrimidones, their preparation and compositions containing them |
GB1209629A (en) * | 1966-11-29 | 1970-10-21 | Ciba Ltd | Novel pyrimido-benzthiazole and -benzoxazole compounds, process for their manufacture, and compositions containing them |
US3907799A (en) * | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
FR2335229A1 (fr) * | 1975-12-19 | 1977-07-15 | Boehringer Sohn Ingelheim | Nouveaux derives de quinazolone, leur preparation et leur utilisation en tant que medicaments |
FR2401159A1 (fr) * | 1977-05-25 | 1979-03-23 | Bristol Myers Co | Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique |
Also Published As
Publication number | Publication date |
---|---|
NL7903535A (nl) | 1979-11-07 |
DE2918085A1 (de) | 1979-11-15 |
SE445642B (sv) | 1986-07-07 |
IE790912L (en) | 1979-11-05 |
YU103679A (en) | 1983-02-28 |
FI65260B (fi) | 1983-12-30 |
SE7903927L (sv) | 1979-11-06 |
AU4666779A (en) | 1979-11-22 |
GR72717B (fr) | 1983-12-01 |
US4223031A (en) | 1980-09-16 |
BE876059A (fr) | 1979-11-05 |
FI791411A (fi) | 1979-11-06 |
DK185079A (da) | 1979-11-06 |
ZA792130B (en) | 1980-06-25 |
FI65260C (fi) | 1984-04-10 |
SE8404151L (sv) | 1984-08-20 |
JPS54145696A (en) | 1979-11-14 |
AU528715B2 (en) | 1983-05-12 |
GB2020654A (en) | 1979-11-21 |
LU81231A1 (fr) | 1979-12-06 |
GB2020654B (en) | 1982-08-04 |
SE8404151D0 (sv) | 1984-08-20 |
CH651300A5 (de) | 1985-09-13 |
FR2424924B1 (fr) | 1983-01-14 |
CH641460A5 (de) | 1984-02-29 |
CA1109870A (fr) | 1981-09-29 |
IE47976B1 (en) | 1984-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |