WO2009007675A2 - Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires - Google Patents

Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires Download PDF

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Publication number
WO2009007675A2
WO2009007675A2 PCT/GB2008/002201 GB2008002201W WO2009007675A2 WO 2009007675 A2 WO2009007675 A2 WO 2009007675A2 GB 2008002201 W GB2008002201 W GB 2008002201W WO 2009007675 A2 WO2009007675 A2 WO 2009007675A2
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WO
WIPO (PCT)
Prior art keywords
mast cell
pharmaceutically
antagonist
kit
cell inhibitor
Prior art date
Application number
PCT/GB2008/002201
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English (en)
Other versions
WO2009007675A3 (fr
Inventor
Johan Raud
Carl-Johan Dalsgaard
Original Assignee
Cardoz Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardoz Ab filed Critical Cardoz Ab
Publication of WO2009007675A2 publication Critical patent/WO2009007675A2/fr
Publication of WO2009007675A3 publication Critical patent/WO2009007675A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

L'invention porte sur des produits d'association comprenant (a) un inhibiteur de mastocyte, ou un sel ou solvate pharmaceutiquement acceptable de celui-ci; et (b) un antagoniste P2Y12, ou un sel ou solvate pharmaceutiquement acceptable de celui-ci. De tels produits d'association ont une utilité particulière dans le traitement de l'athérosclérose et d'états apparentés.
PCT/GB2008/002201 2007-07-11 2008-06-25 Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires WO2009007675A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92972907P 2007-07-11 2007-07-11
US92973207P 2007-07-11 2007-07-11
US60/929,729 2007-07-11
US60/929,732 2007-07-11

Publications (2)

Publication Number Publication Date
WO2009007675A2 true WO2009007675A2 (fr) 2009-01-15
WO2009007675A3 WO2009007675A3 (fr) 2009-03-12

Family

ID=39769186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/002201 WO2009007675A2 (fr) 2007-07-11 2008-06-25 Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires

Country Status (1)

Country Link
WO (1) WO2009007675A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2229172A1 (fr) * 2007-12-03 2010-09-22 AstraZeneca AB Composés de triazolo [4,5-d] pyrimidine pour le traitement d'anévrysmes aortiques abdominaux
WO2010139985A1 (fr) * 2009-06-01 2010-12-09 Biocopea Limited Utilisation de l'amlexanoxe comme thérapie des maladies induites par les neutrophiles
EP2377520A1 (fr) * 2010-03-24 2011-10-19 Ratiopharm GmbH Composition pharmaceutique du prasugrel
EP2505196A1 (fr) * 2009-11-27 2012-10-03 Tokai University Educational System Agent antithrombotique
US8663661B2 (en) * 2009-12-23 2014-03-04 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor
WO2017125739A1 (fr) * 2016-01-21 2017-07-27 Rspr Pharma Ab Nouvelle utilisation de pémirolast
CN109646442A (zh) * 2019-01-29 2019-04-19 军事科学院军事医学研究院生物医学分析中心 乙酸酯类化合物在制备环鸟腺苷合成酶乙酰化药物中的用途

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086349A (en) * 1975-07-30 1978-04-25 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
EP0316174A1 (fr) * 1987-11-10 1989-05-17 Tokyo Tanabe Company Limited Préparation aqueuse du sel de potassium du 9-méthyle-3-(1H-tétrazol-5-yle)-4H-pyrido[1,2-a]-pyrimidine-4-one
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WO2007024472A2 (fr) * 2005-08-19 2007-03-01 Eli Lilly And Company Procede pour le traitement de maladies vasculaires

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
EP0316174A1 (fr) * 1987-11-10 1989-05-17 Tokyo Tanabe Company Limited Préparation aqueuse du sel de potassium du 9-méthyle-3-(1H-tétrazol-5-yle)-4H-pyrido[1,2-a]-pyrimidine-4-one
EP0766963A1 (fr) * 1994-05-31 1997-04-09 Tokyo Tanabe Company Limited Depresseur de l'arteriosclerose
US6585995B1 (en) * 1999-09-21 2003-07-01 Hanson Stephen R Methods and compositions for treating platelet-related disorders
US20020103219A1 (en) * 2000-10-05 2002-08-01 Jeremy Jacob Stable viscous liquid formulations of amlexanox for the prevention and treatment of mucosal diseases and disorders
EP1285921A1 (fr) * 2001-08-10 2003-02-26 Dinamite Dipharma S.p.A. Procédé de la fabrication de pemirolast pure
US20050181023A1 (en) * 2004-02-17 2005-08-18 Young Janel E. Drug-enhanced adhesion prevention
WO2005092264A1 (fr) * 2004-03-10 2005-10-06 Ethicon, Inc. Prevention des adherences amelioree par des medicaments
WO2007024472A2 (fr) * 2005-08-19 2007-03-01 Eli Lilly And Company Procede pour le traitement de maladies vasculaires

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YAMADA N ET AL: "MY-1250, a major metabolite of the anti-allergic drug repirinast, induces phosphorylation of a 78-kDa protein in rat mast cells" BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 44, no. 6, 25 September 1992 (1992-09-25), pages 1211-1213, XP023732179 ISSN: 0006-2952 [retrieved on 1992-09-25] *
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2229172A1 (fr) * 2007-12-03 2010-09-22 AstraZeneca AB Composés de triazolo [4,5-d] pyrimidine pour le traitement d'anévrysmes aortiques abdominaux
EP2229172A4 (fr) * 2007-12-03 2012-12-26 Astrazeneca Ab Composés de triazolo [4,5-d] pyrimidine pour le traitement d'anévrysmes aortiques abdominaux
WO2010139985A1 (fr) * 2009-06-01 2010-12-09 Biocopea Limited Utilisation de l'amlexanoxe comme thérapie des maladies induites par les neutrophiles
JP2012528844A (ja) * 2009-06-01 2012-11-15 バイオコピア リミテッド 好中球によって引き起こされる疾患の治療におけるアンレキサノクスの使用
EP2505196A1 (fr) * 2009-11-27 2012-10-03 Tokai University Educational System Agent antithrombotique
EP2505196A4 (fr) * 2009-11-27 2013-05-01 Univ Tokai Educational System Agent antithrombotique
US8663661B2 (en) * 2009-12-23 2014-03-04 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor
US20140147505A1 (en) * 2009-12-23 2014-05-29 Ratiopharm Gmbh Solid pharmaceutical dosage form of ticagrelor
EP2377520A1 (fr) * 2010-03-24 2011-10-19 Ratiopharm GmbH Composition pharmaceutique du prasugrel
WO2017125739A1 (fr) * 2016-01-21 2017-07-27 Rspr Pharma Ab Nouvelle utilisation de pémirolast
CN109646442A (zh) * 2019-01-29 2019-04-19 军事科学院军事医学研究院生物医学分析中心 乙酸酯类化合物在制备环鸟腺苷合成酶乙酰化药物中的用途

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