WO2001035938A3 - Pharmakologisch aktive tetrahydrothiopyran-4-ol-derivate, verfahren zu ihrer herstellung und verwendung - Google Patents

Pharmakologisch aktive tetrahydrothiopyran-4-ol-derivate, verfahren zu ihrer herstellung und verwendung Download PDF

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Publication number
WO2001035938A3
WO2001035938A3 PCT/EP2000/011081 EP0011081W WO0135938A3 WO 2001035938 A3 WO2001035938 A3 WO 2001035938A3 EP 0011081 W EP0011081 W EP 0011081W WO 0135938 A3 WO0135938 A3 WO 0135938A3
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WO
WIPO (PCT)
Prior art keywords
general formula
compounds
derivatives
production
pharmacologically active
Prior art date
Application number
PCT/EP2000/011081
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English (en)
French (fr)
Other versions
WO2001035938A2 (de
Inventor
Shyam Sunder Chatterje
Klaus Klessing
Original Assignee
Schwabe Willmar Gmbh & Co
Shyam Sunder Chatterje
Klaus Klessing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwabe Willmar Gmbh & Co, Shyam Sunder Chatterje, Klaus Klessing filed Critical Schwabe Willmar Gmbh & Co
Priority to AU19993/01A priority Critical patent/AU1999301A/en
Publication of WO2001035938A2 publication Critical patent/WO2001035938A2/de
Publication of WO2001035938A3 publication Critical patent/WO2001035938A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Erfindungsgemäß vorgeschlagen wird die Verwendung von Tetrahydrothiopyran-4-olen der allgemeinen Formel, worin n eine ganze Zahl von 0 bis 2 und R eine geradkettige oder verzweigte Alkyl-, Alkenyl- oder Alkinyl-Gruppe mit 2 bis 6 C-Atomen oder einen gegebenenfalls substituierten Phenyl-Rest bedeuten, als Wirkstoffe zur Prophylaxe und Behandlung von Erkrankungen des Zentralnervensystems und zur Herstellung ZNS-relevanter Arzneimittel. Einige der Verbindungen der allgemeinen Formel (I) sind neu, bei anderen ist die medizinische Indikation neu. Vorgeschlagen werden ferner Verfahren zur Herstellung der Verbindungen der allgemeinen Formel (I) und Arzneimittel, die mindestens eine dieser Verbindungen enthalten.
PCT/EP2000/011081 1999-11-12 2000-11-09 Pharmakologisch aktive tetrahydrothiopyran-4-ol-derivate, verfahren zu ihrer herstellung und verwendung WO2001035938A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19993/01A AU1999301A (en) 1999-11-12 2000-11-09 Pharmacologically active tetrahydro thiopyran-4-ol derivatives, method for theirproduction and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19954569A DE19954569A1 (de) 1999-11-12 1999-11-12 Pharmakologisch aktive Tetrahydrothiopyran-4-ol-Derivate, Verfahren zu ihrer Herstellung und Verwendung
DE19954569.3 1999-11-12

Publications (2)

Publication Number Publication Date
WO2001035938A2 WO2001035938A2 (de) 2001-05-25
WO2001035938A3 true WO2001035938A3 (de) 2002-02-14

Family

ID=7928879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011081 WO2001035938A2 (de) 1999-11-12 2000-11-09 Pharmakologisch aktive tetrahydrothiopyran-4-ol-derivate, verfahren zu ihrer herstellung und verwendung

Country Status (3)

Country Link
AU (1) AU1999301A (de)
DE (1) DE19954569A1 (de)
WO (1) WO2001035938A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL365694A1 (en) 2000-06-28 2005-01-10 Teva Pharmaceutical Industries Ltd. Carvedilol
KR20040077872A (ko) 2002-01-15 2004-09-07 테바 파마슈티컬 인더스트리즈 리미티드 카베디롤의 결정질 고체 및 그 제조 방법
WO2008002683A2 (en) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018024A1 (en) * 1992-03-04 1993-09-16 Rhone-Poulenc Rorer Limited 1-alkoxy-2-(alkoxy- or cycloalkoxy)-4-(cyclo thioalkyl- or cyclothioalkenyl)benzenes as inhibitors of cyclic amp phosphodiesterase and tumour necrosis factor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018024A1 (en) * 1992-03-04 1993-09-16 Rhone-Poulenc Rorer Limited 1-alkoxy-2-(alkoxy- or cycloalkoxy)-4-(cyclo thioalkyl- or cyclothioalkenyl)benzenes as inhibitors of cyclic amp phosphodiesterase and tumour necrosis factor

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BENNETT G M ET AL: "STUDIES IN THE PENTHIAN SERIES. PART III. STEREOISOMERIC DERIVATIVES OF SOME PENTHIANOLS", JOURNAL OF THE CHEMICAL SOCIETY, XX, XX, 1929, pages 2832 - 2838, XP000984301 *
CHEMICAL ABSTRACTS, vol. 54, no. 21, 10 November 1960, Columbus, Ohio, US; abstract no. 22618c, ONESTA, ROMEO ET AL: "synthesis of 4-alkyl thiacyclohexanes" XP002175146 *
CHEMICAL ABSTRACTS, vol. 60, no. 7, 30 March 1964, Columbus, Ohio, US; abstract no. 7984d, ZAGOREVSKII, V. A. ET AL: "pyran series, its analogs and related compds. - (IV) 4-alkyl-4- aminotetrahydrothiopyrans" XP002175147 *
CHEMICAL ABSTRACTS, vol. 62, no. 13, 21 June 1965, Columbus, Ohio, US; abstract no. 16190d, ZAGOREVSKII, V. A. ET AL: "pyran series, its analogs and related compds. - (XI) application of the Ritter reaction to heterocyclic tertiary alcs." XP002175145 *
CRUMBIE, ROBYN L. ET AL: "Stereoselectivity in the reactions between the anion of 4-phenyl-5,6-dihydro-2H-thiopyran 1-oxide and electrophiles", AUST. J. CHEM. (1985), 38(1), 119-32, XP001014583 *
GAZZ. CHIM. ITAL., vol. 89, 1959, pages 1127 - 1138 *
GRAHAM C CRAWLEY ET AL: "Methoxytetrahydropyrans.A new series of selective and orally potent 5-lipoxygenase inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 14, 10 July 1992 (1992-07-10), pages 2600 - 2609, XP002012228, ISSN: 0022-2623 *
P. LÄUGER ET AL.: "Carbinols, carbamates et esters propynyliques, et leur activité hypnotique", HELVETICA CHIMICA ACTA, vol. 42, no. 7, 1959, pages 2379 - 2393, XP001015766 *
ZH. OBSHCH. KHIM., vol. 33, no. 11, 1963, pages 3569 - 3572 *
ZH. ORGAN. KHIM., vol. 1, no. 2, 1965, pages 366 - 369 *

Also Published As

Publication number Publication date
AU1999301A (en) 2001-05-30
WO2001035938A2 (de) 2001-05-25
DE19954569A1 (de) 2001-05-17

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