ES477164A1 - Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina. - Google Patents
Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina.Info
- Publication number
- ES477164A1 ES477164A1 ES477164A ES477164A ES477164A1 ES 477164 A1 ES477164 A1 ES 477164A1 ES 477164 A ES477164 A ES 477164A ES 477164 A ES477164 A ES 477164A ES 477164 A1 ES477164 A1 ES 477164A1
- Authority
- ES
- Spain
- Prior art keywords
- diazepine
- diazepine derivatives
- duodenyl
- thieno
- gastro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Abstract
Un procedimiento de preparación de 6-ciclopropil-1,3-dihidro-5-fenil-2-oxo-2H-tieno {2,3-e} diazapina, caracterizado por: (a) hacer reaccionar ciclopropilmetilcetona con benzoilacetonitrilo en benceno, en presencia de ácido acético, para formar 2-benzoil-3- ciclopropil-crotonitrilo; (b) tratar este último compuesto con azufre en etanol, en presencia de trietilamina, para obtener 2-amino-3-benzoil-4-ciclopropil-tiofeno; (c) hacer reaccionar bromuro del ácido bromoacético con este último compuesto, en éter y en presencia de piridina, a la temperatura ambiente, para formar 3-benzoil-2-alfa- bromoacetamido-4-ciclopropil-tiofeno; (d) aminar este último con amoniaco en tetrahidrofurano para obtener 2-alfa-aminoacetamido-3-benzoiil-4-cicloporpil-tiofeno y (e) ciclar este último mediante calentamiento a reflujo en tolueno, en presencia de ácido acético, para obtener 6-ciclopropil-1,3-dihidro-5-fenil-2-oxo-2H-tieno {2,3-e} diazapina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1358777 | 1977-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES477164A1 true ES477164A1 (es) | 1979-10-16 |
Family
ID=10025687
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES468382A Expired ES468382A1 (es) | 1977-03-31 | 1978-03-30 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihidro-1-metil-5-fenil-2-oxo-2h-tieno(2,3-e)diazepina |
ES477164A Expired ES477164A1 (es) | 1977-03-31 | 1979-01-25 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihi- dro-5-fenil-2-oxo-2h-tieno (2,3-e) diazepina. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES468382A Expired ES468382A1 (es) | 1977-03-31 | 1978-03-30 | Un procedimiento de preparacion de 6-ciclopropil-1,3-dihidro-1-metil-5-fenil-2-oxo-2h-tieno(2,3-e)diazepina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4156009A (es) |
JP (1) | JPS53121791A (es) |
AR (1) | AR215171A1 (es) |
AU (1) | AU3495678A (es) |
BE (1) | BE865278A (es) |
DD (2) | DD137108A5 (es) |
DE (1) | DE2813996A1 (es) |
DK (1) | DK135478A (es) |
ES (2) | ES468382A1 (es) |
FR (1) | FR2385721A1 (es) |
GR (1) | GR62853B (es) |
NL (1) | NL7803431A (es) |
NO (1) | NO781102L (es) |
PT (1) | PT67813A (es) |
SE (1) | SE7803604L (es) |
SU (1) | SU715027A3 (es) |
ZA (1) | ZA781694B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0225554D0 (en) * | 2002-11-01 | 2002-12-11 | Syngenta Participations Ag | Chemical compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1256548A (es) * | 1968-12-10 | 1971-12-08 | ||
CA927388A (en) * | 1970-02-17 | 1973-05-29 | Nakanishi Michio | Thieno (2,3-e)(1,4)diazepin-2-ones |
US3806512A (en) * | 1970-09-03 | 1974-04-23 | Yoshitomi Pharmaceutical | 2-amino-3-pyridylcarbonylthiophene compounds |
FI53214C (es) * | 1970-11-16 | 1978-03-10 | Sumitomo Chemical Co | |
US3872089A (en) * | 1971-05-14 | 1975-03-18 | Hoffmann La Roche | Substituted thienodiazepines |
GB1345998A (en) * | 1971-05-31 | 1974-02-06 | Yoshitomi Pharmaceutical | Thienodiazepine compounds and pharmaceutical compositions containining them |
JPS5750794B2 (es) * | 1973-02-03 | 1982-10-28 | ||
JPS5729472B2 (es) * | 1974-05-02 | 1982-06-23 |
-
1978
- 1978-03-16 FR FR7807697A patent/FR2385721A1/fr not_active Withdrawn
- 1978-03-23 ZA ZA00781694A patent/ZA781694B/xx unknown
- 1978-03-23 GR GR55787A patent/GR62853B/el unknown
- 1978-03-23 PT PT67813A patent/PT67813A/pt unknown
- 1978-03-24 BE BE2056799A patent/BE865278A/xx unknown
- 1978-03-27 US US05/890,410 patent/US4156009A/en not_active Expired - Lifetime
- 1978-03-27 JP JP3525278A patent/JPS53121791A/ja active Pending
- 1978-03-27 AR AR271535A patent/AR215171A1/es active
- 1978-03-28 DK DK135478A patent/DK135478A/da unknown
- 1978-03-29 DD DD78204460A patent/DD137108A5/xx unknown
- 1978-03-29 DD DD78213659A patent/DD143777A5/de unknown
- 1978-03-30 SU SU782594351A patent/SU715027A3/ru active
- 1978-03-30 NO NO781102A patent/NO781102L/no unknown
- 1978-03-30 ES ES468382A patent/ES468382A1/es not_active Expired
- 1978-03-30 SE SE7803604A patent/SE7803604L/xx unknown
- 1978-03-31 NL NL7803431A patent/NL7803431A/xx not_active Application Discontinuation
- 1978-03-31 DE DE19782813996 patent/DE2813996A1/de active Pending
- 1978-04-11 AU AU34956/78A patent/AU3495678A/en active Pending
-
1979
- 1979-01-25 ES ES477164A patent/ES477164A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NO781102L (no) | 1978-10-03 |
ZA781694B (en) | 1979-03-28 |
AR215171A1 (es) | 1979-09-14 |
PT67813A (fr) | 1978-04-01 |
ES468382A1 (es) | 1979-10-01 |
SU715027A3 (ru) | 1980-02-05 |
DD143777A5 (de) | 1980-09-10 |
GR62853B (en) | 1979-06-20 |
DD137108A5 (de) | 1979-08-15 |
SE7803604L (sv) | 1978-10-01 |
AU3495678A (en) | 1979-10-18 |
BE865278A (fr) | 1978-09-25 |
DE2813996A1 (de) | 1978-10-05 |
US4156009A (en) | 1979-05-22 |
FR2385721A1 (fr) | 1978-10-27 |
DK135478A (da) | 1978-10-01 |
NL7803431A (nl) | 1978-10-03 |
JPS53121791A (en) | 1978-10-24 |
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