HUP0204085A2 - Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0204085A2 HUP0204085A2 HU0204085A HUP0204085A HUP0204085A2 HU P0204085 A2 HUP0204085 A2 HU P0204085A2 HU 0204085 A HU0204085 A HU 0204085A HU P0204085 A HUP0204085 A HU P0204085A HU P0204085 A2 HUP0204085 A2 HU P0204085A2
- Authority
- HU
- Hungary
- Prior art keywords
- treatment
- group
- carbon atoms
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010003119 arrhythmia Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 hydroxy- Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgyát az általános képletű vegyületek - ahol R1 adottesetben szubsztituált alkilcsoport; R2 hidrogén-, halogénatom, 1-6szénatomos alkilcsoport; R3 hidrogénatom, 1-6 szénatomos alkilcsoportvagy R2-vel együtt =O csoport R4 egy vagy több hidroxi-, ciano-,halogén-, nitro-, 1-6 szénatomos - adott esetben szubsztituált -alkilcsoport; R41-R46 egymástól függetlenül hidrogénatom vagy 1-6szénatomos alkilcsoport; A közvetlen kötés vagy egyéb összekötőcsoport; B összekötő csoport; G =CH- csoport vagy nitrogénatom - ésgyógyszerészetileg elfogadható származékaik, valamint ezekettartalmazó, aritmiák kezelésében alkalmazható gyógyszerkészítményekképezik. A találmány kiterjed a vegyületek előállítási eljárására is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9903759A SE9903759D0 (sv) | 1999-10-18 | 1999-10-18 | Pharmaceutically active compounds |
PCT/SE2000/001994 WO2001028992A2 (en) | 1999-10-18 | 2000-10-13 | New oxabispidine compounds useful in the treatment of cardiac arrhythmias |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0204085A2 true HUP0204085A2 (hu) | 2003-04-28 |
HUP0204085A3 HUP0204085A3 (en) | 2006-01-30 |
Family
ID=20417401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204085A HUP0204085A3 (en) | 1999-10-18 | 2000-10-13 | New oxabispidine compounds useful in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them |
Country Status (41)
Country | Link |
---|---|
US (6) | US6559143B1 (hu) |
EP (2) | EP1235831B1 (hu) |
JP (3) | JP3973906B2 (hu) |
KR (1) | KR100796142B1 (hu) |
CN (2) | CN101265262A (hu) |
AP (1) | AP1536A (hu) |
AR (2) | AR026064A1 (hu) |
AT (1) | ATE292134T1 (hu) |
AU (1) | AU769513B2 (hu) |
BG (1) | BG65785B1 (hu) |
BR (1) | BR0014804A (hu) |
CA (1) | CA2386910A1 (hu) |
CO (1) | CO5271655A1 (hu) |
CU (1) | CU23210A3 (hu) |
CZ (1) | CZ20021328A3 (hu) |
DE (1) | DE60019158T2 (hu) |
DK (1) | DK1235831T3 (hu) |
EA (1) | EA005319B1 (hu) |
EE (1) | EE04854B1 (hu) |
ES (1) | ES2239047T3 (hu) |
HK (1) | HK1049003B (hu) |
HR (1) | HRP20020336B1 (hu) |
HU (1) | HUP0204085A3 (hu) |
IL (5) | IL149108A0 (hu) |
IS (2) | IS2224B (hu) |
MX (1) | MXPA02003848A (hu) |
MY (1) | MY130661A (hu) |
NO (1) | NO327977B1 (hu) |
NZ (2) | NZ518156A (hu) |
OA (1) | OA12067A (hu) |
PL (1) | PL354970A1 (hu) |
PT (1) | PT1235831E (hu) |
RS (1) | RS50760B (hu) |
SE (1) | SE9903759D0 (hu) |
SI (1) | SI1235831T1 (hu) |
SK (1) | SK286723B6 (hu) |
TR (1) | TR200201059T2 (hu) |
TW (1) | TWI283680B (hu) |
UA (1) | UA75052C2 (hu) |
WO (1) | WO2001028992A2 (hu) |
ZA (1) | ZA200202575B (hu) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
AR030756A1 (es) * | 2000-10-02 | 2003-09-03 | Astrazeneca Ab | Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas |
SE0101324D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
SE0101323D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
TWI259836B (en) * | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
SE0101329D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Pharmaceutical formulation |
SE0101327D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New crystalline forms |
BR0214225A (pt) * | 2001-11-22 | 2004-09-21 | Astrazeneca Ab | Processos para a preparação e para a formação de um composto, e, composto |
SE0201373D0 (sv) * | 2002-05-06 | 2002-05-06 | Astrazeneca Ab | Combination therapy |
SE0201374D0 (sv) * | 2002-05-06 | 2002-05-06 | Astrazeneca Ab | Pharmaceutical combination |
SE0201662D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Pharmaceutical combination |
GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
WO2006135316A1 (en) * | 2005-06-13 | 2006-12-21 | Astrazeneca Ab | New oxabispidine compounds for the treatment of cardiac arrhythmias |
AR057363A1 (es) * | 2005-06-20 | 2007-11-28 | Astrazeneca Ab | Proceso para la preparacion de oxabispidinas n,n'-disustituidas |
AR054391A1 (es) * | 2005-06-20 | 2007-06-20 | Astrazeneca Ab | Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos |
KR20080019245A (ko) * | 2005-06-20 | 2008-03-03 | 아스트라제네카 아베 | 옥사비스피딘의 술폰산염의 제조 방법 |
WO2006137772A1 (en) * | 2005-06-20 | 2006-12-28 | Astrazeneca Ab | New physical form of n,n´- disubstituted oxabispidines |
CN1330636C (zh) * | 2005-09-26 | 2007-08-08 | 鲁南制药集团股份有限公司 | 盐酸替罗非班中间体的合成方法 |
TW200734342A (en) * | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
GB2495308B (en) * | 2011-10-05 | 2014-09-10 | John Royce | Method and apparatus for cleaning a filter |
EA034922B1 (ru) | 2013-03-15 | 2020-04-07 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
US10231970B2 (en) | 2014-09-30 | 2019-03-19 | NV Heterocycles | Methods of producing heteropolycycles via bis-epoxidation |
Family Cites Families (23)
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US3196154A (en) | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
US3503939A (en) | 1967-03-29 | 1970-03-31 | Du Pont | Polyamides from heterocyclic diamines |
CH488048A (de) | 1969-06-12 | 1970-03-31 | Inventa Ag | Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung |
JPS5772977A (en) * | 1980-10-23 | 1982-05-07 | Dainippon Ink & Chem Inc | Fluorine-containing diepoxy compound and its preparation |
DE3112055A1 (de) | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
US4533713A (en) * | 1983-05-06 | 1985-08-06 | Minnesota Mining And Manufacturing Company | Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups |
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JPS6284071A (ja) * | 1985-10-07 | 1987-04-17 | Kanegafuchi Chem Ind Co Ltd | 新規グリシジル化合物及びその製造方法 |
JPS6284070A (ja) | 1985-10-07 | 1987-04-17 | Kanegafuchi Chem Ind Co Ltd | 新規なグリシジル化合物及びその製造法 |
DE3732094A1 (de) | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
US5140033A (en) | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
US5110933A (en) | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
FR2664270B1 (fr) * | 1990-07-09 | 1994-04-08 | Norsolor Sa | Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres. |
JP2602745B2 (ja) * | 1991-06-26 | 1997-04-23 | 花王株式会社 | フレキシブルディスク用センターハブのピッキング装置 |
US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
US5831099A (en) | 1995-03-10 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Army | Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same |
SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
SE9803517D0 (sv) * | 1998-10-15 | 1998-10-15 | Astra Ab | Pharmaceutical preparation |
PL350907A1 (en) | 1999-04-09 | 2003-02-10 | Astrazeneca Ab | Adamantane derivatives |
SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
SE9904765D0 (sv) * | 1999-12-23 | 1999-12-23 | Astra Ab | Pharmaceutically-useful compounds |
AR030756A1 (es) * | 2000-10-02 | 2003-09-03 | Astrazeneca Ab | Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas |
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1999
- 1999-10-18 SE SE9903759A patent/SE9903759D0/xx unknown
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2000
- 2000-10-06 TW TW089120910A patent/TWI283680B/zh not_active IP Right Cessation
- 2000-10-13 HU HU0204085A patent/HUP0204085A3/hu unknown
- 2000-10-13 RS YUP-294/02A patent/RS50760B/sr unknown
- 2000-10-13 CN CNA2008100058488A patent/CN101265262A/zh active Pending
- 2000-10-13 PT PT00971960T patent/PT1235831E/pt unknown
- 2000-10-13 AT AT00971960T patent/ATE292134T1/de not_active IP Right Cessation
- 2000-10-13 WO PCT/SE2000/001994 patent/WO2001028992A2/en active Application Filing
- 2000-10-13 ES ES00971960T patent/ES2239047T3/es not_active Expired - Lifetime
- 2000-10-13 AP APAP/P/2002/002471A patent/AP1536A/en active
- 2000-10-13 JP JP2001531792A patent/JP3973906B2/ja not_active Expired - Fee Related
- 2000-10-13 BR BR0014804-0A patent/BR0014804A/pt not_active IP Right Cessation
- 2000-10-13 IL IL14910800A patent/IL149108A0/xx unknown
- 2000-10-13 OA OA1200200113A patent/OA12067A/en unknown
- 2000-10-13 EP EP00971960A patent/EP1235831B1/en not_active Expired - Lifetime
- 2000-10-13 NZ NZ518156A patent/NZ518156A/en unknown
- 2000-10-13 CZ CZ20021328A patent/CZ20021328A3/cs unknown
- 2000-10-13 EA EA200200390A patent/EA005319B1/ru not_active IP Right Cessation
- 2000-10-13 EE EEP200200203A patent/EE04854B1/xx not_active IP Right Cessation
- 2000-10-13 EP EP05006781A patent/EP1559717A3/en not_active Withdrawn
- 2000-10-13 SI SI200030681T patent/SI1235831T1/xx unknown
- 2000-10-13 SK SK506-2002A patent/SK286723B6/sk not_active IP Right Cessation
- 2000-10-13 MX MXPA02003848A patent/MXPA02003848A/es active IP Right Grant
- 2000-10-13 CA CA002386910A patent/CA2386910A1/en not_active Abandoned
- 2000-10-13 PL PL00354970A patent/PL354970A1/xx not_active Application Discontinuation
- 2000-10-13 AU AU10691/01A patent/AU769513B2/en not_active Ceased
- 2000-10-13 TR TR2002/01059T patent/TR200201059T2/xx unknown
- 2000-10-13 DE DE60019158T patent/DE60019158T2/de not_active Expired - Lifetime
- 2000-10-13 NZ NZ531260A patent/NZ531260A/en unknown
- 2000-10-13 UA UA2002043168A patent/UA75052C2/uk unknown
- 2000-10-13 DK DK00971960T patent/DK1235831T3/da active
- 2000-10-13 CN CNB00816231XA patent/CN100379743C/zh not_active Expired - Fee Related
- 2000-10-13 KR KR1020027004902A patent/KR100796142B1/ko not_active IP Right Cessation
- 2000-10-16 US US09/688,251 patent/US6559143B1/en not_active Expired - Fee Related
- 2000-10-16 MY MYPI20004850A patent/MY130661A/en unknown
- 2000-10-17 CO CO00078740A patent/CO5271655A1/es not_active Application Discontinuation
- 2000-10-17 AR ARP000105452A patent/AR026064A1/es active IP Right Grant
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2002
- 2002-04-02 ZA ZA200202575A patent/ZA200202575B/en unknown
- 2002-04-05 BG BG106588A patent/BG65785B1/bg unknown
- 2002-04-11 IL IL183854A patent/IL183854A0/en unknown
- 2002-04-11 IL IL149108A patent/IL149108A/en not_active IP Right Cessation
- 2002-04-16 CU CU20020079A patent/CU23210A3/es not_active IP Right Cessation
- 2002-04-16 HR HR20020336A patent/HRP20020336B1/xx not_active IP Right Cessation
- 2002-04-17 IS IS6346A patent/IS2224B/is unknown
- 2002-04-17 NO NO20021811A patent/NO327977B1/no not_active IP Right Cessation
- 2002-12-12 US US10/317,195 patent/US7164017B2/en not_active Expired - Fee Related
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2003
- 2003-02-18 HK HK03101241.2A patent/HK1049003B/zh not_active IP Right Cessation
- 2003-04-02 AR ARP030101150A patent/AR039226A2/es unknown
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2006
- 2006-03-22 US US11/385,861 patent/US20060166980A1/en not_active Abandoned
- 2006-03-22 US US11/385,833 patent/US7772229B2/en not_active Expired - Fee Related
- 2006-08-23 JP JP2006226089A patent/JP2006342182A/ja active Pending
- 2006-12-18 US US11/640,417 patent/US7351821B2/en not_active Expired - Fee Related
- 2006-12-27 IS IS8586A patent/IS8586A/is unknown
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2007
- 2007-03-28 JP JP2007083302A patent/JP2007204486A/ja active Pending
- 2007-06-11 IL IL183853A patent/IL183853A0/en unknown
- 2007-06-11 IL IL183852A patent/IL183852A0/en unknown
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2009
- 2009-09-01 US US12/585,029 patent/US20090326221A1/en not_active Abandoned
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