HUP0204085A2 - Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0204085A2
HUP0204085A2 HU0204085A HUP0204085A HUP0204085A2 HU P0204085 A2 HUP0204085 A2 HU P0204085A2 HU 0204085 A HU0204085 A HU 0204085A HU P0204085 A HUP0204085 A HU P0204085A HU P0204085 A2 HUP0204085 A2 HU P0204085A2
Authority
HU
Hungary
Prior art keywords
treatment
group
carbon atoms
preparation
pharmaceutical compositions
Prior art date
Application number
HU0204085A
Other languages
English (en)
Inventor
Annika Björe
Magnus Björsne
David Cladingboel
Kurt-Jürgen Hoffman
John Pavey
Fritiof Pontén
Gert Strandlund
Peder Svensson
Colin Thomson
Michael Wilstermann
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0204085A2 publication Critical patent/HUP0204085A2/hu
Publication of HUP0204085A3 publication Critical patent/HUP0204085A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol R1 adottesetben szubsztituált alkilcsoport; R2 hidrogén-, halogénatom, 1-6szénatomos alkilcsoport; R3 hidrogénatom, 1-6 szénatomos alkilcsoportvagy R2-vel együtt =O csoport R4 egy vagy több hidroxi-, ciano-,halogén-, nitro-, 1-6 szénatomos - adott esetben szubsztituált -alkilcsoport; R41-R46 egymástól függetlenül hidrogénatom vagy 1-6szénatomos alkilcsoport; A közvetlen kötés vagy egyéb összekötőcsoport; B összekötő csoport; G =CH- csoport vagy nitrogénatom - ésgyógyszerészetileg elfogadható származékaik, valamint ezekettartalmazó, aritmiák kezelésében alkalmazható gyógyszerkészítményekképezik. A találmány kiterjed a vegyületek előállítási eljárására is. Ó
HU0204085A 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them HUP0204085A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
HUP0204085A2 true HUP0204085A2 (hu) 2003-04-28
HUP0204085A3 HUP0204085A3 (en) 2006-01-30

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0204085A HUP0204085A3 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias, process for their preparation and pharmaceutical compositions containing them

Country Status (41)

Country Link
US (6) US6559143B1 (hu)
EP (2) EP1559717A3 (hu)
JP (3) JP3973906B2 (hu)
KR (1) KR100796142B1 (hu)
CN (2) CN101265262A (hu)
AP (1) AP1536A (hu)
AR (2) AR026064A1 (hu)
AT (1) ATE292134T1 (hu)
AU (1) AU769513B2 (hu)
BG (1) BG65785B1 (hu)
BR (1) BR0014804A (hu)
CA (1) CA2386910A1 (hu)
CO (1) CO5271655A1 (hu)
CU (1) CU23210A3 (hu)
CZ (1) CZ20021328A3 (hu)
DE (1) DE60019158T2 (hu)
DK (1) DK1235831T3 (hu)
EA (1) EA005319B1 (hu)
EE (1) EE04854B1 (hu)
ES (1) ES2239047T3 (hu)
HK (1) HK1049003B (hu)
HR (1) HRP20020336B1 (hu)
HU (1) HUP0204085A3 (hu)
IL (5) IL149108A0 (hu)
IS (2) IS2224B (hu)
MX (1) MXPA02003848A (hu)
MY (1) MY130661A (hu)
NO (1) NO327977B1 (hu)
NZ (2) NZ518156A (hu)
OA (1) OA12067A (hu)
PL (1) PL354970A1 (hu)
PT (1) PT1235831E (hu)
RS (1) RS50760B (hu)
SE (1) SE9903759D0 (hu)
SI (1) SI1235831T1 (hu)
SK (1) SK286723B6 (hu)
TR (1) TR200201059T2 (hu)
TW (1) TWI283680B (hu)
UA (1) UA75052C2 (hu)
WO (1) WO2001028992A2 (hu)
ZA (1) ZA200202575B (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
JP2005514376A (ja) * 2001-11-22 2005-05-19 アストラゼネカ アクチボラグ ２−アミノメチル−２，３−ジヒドロオキサジンからの２−又は−９−オキサ−３，７−ジアザビシクロ（３．３．１）ノナンの調製のための方法、その中間体、及びこのような中間体を調製するための方法
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
AU2006258293B2 (en) * 2005-06-13 2010-06-17 Astrazeneca Ab New oxabispidine compounds for the treatment of cardiac arrhythmias
AR054284A1 (es) * 2005-06-20 2007-06-13 Astrazeneca Ab Procedimiento para la preparacion de sales de acido sulfonico de oxabispidinas
BRPI0611842A2 (pt) * 2005-06-20 2016-08-30 Astrazeneca Ab "processo para a preparação de um composto"
BRPI0611839A2 (pt) * 2005-06-20 2016-08-30 Astrazeneca Ab processos para a preparação de um sal de ácido sulfônico e para a preparação de um composto, e, mistura
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
AP2015008721A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
WO2016054123A1 (en) 2014-09-30 2016-04-07 Lightner Derek Methods of producing heteropolycycles via bis-epoxidation

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
TR200102911T2 (tr) 1999-04-09 2002-01-21 Astrazeneca Ab Adamantan türevleri.
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
ATE292134T1 (de) 2005-04-15
BR0014804A (pt) 2002-06-11
NO327977B1 (no) 2009-11-02
RS50760B (sr) 2010-08-31
SK286723B6 (sk) 2009-04-06
CN101265262A (zh) 2008-09-17
KR20020038956A (ko) 2002-05-24
MXPA02003848A (es) 2002-10-23
IL183854A0 (en) 2009-02-11
CU23210A3 (es) 2007-06-20
UA75052C2 (en) 2006-03-15
DE60019158D1 (de) 2005-05-04
IS6346A (is) 2002-04-17
EP1235831A2 (en) 2002-09-04
HRP20020336B1 (en) 2006-02-28
AR039226A2 (es) 2005-02-09
IS2224B (is) 2007-04-15
EE200200203A (et) 2003-06-16
AU769513B2 (en) 2004-01-29
JP2003512352A (ja) 2003-04-02
SI1235831T1 (hu) 2005-08-31
PL354970A1 (en) 2004-03-22
US20070117799A1 (en) 2007-05-24
ES2239047T3 (es) 2005-09-16
NO20021811L (no) 2002-06-06
BG106588A (en) 2003-01-31
EP1559717A3 (en) 2009-04-29
BG65785B1 (bg) 2009-11-30
US20090326221A1 (en) 2009-12-31
JP2007204486A (ja) 2007-08-16
MY130661A (en) 2007-07-31
CZ20021328A3 (cs) 2002-09-11
IL149108A (en) 2009-12-24
CA2386910A1 (en) 2001-04-26
ZA200202575B (en) 2003-09-23
EP1559717A2 (en) 2005-08-03
CN1399639A (zh) 2003-02-26
EA200200390A1 (ru) 2002-10-31
YU29402A (sh) 2004-12-31
HRP20020336A2 (en) 2004-02-29
US6559143B1 (en) 2003-05-06
AP2002002471A0 (en) 2002-06-30
DE60019158T2 (de) 2006-02-02
CO5271655A1 (es) 2003-04-30
EA005319B1 (ru) 2005-02-24
KR100796142B1 (ko) 2008-01-21
HK1049003B (zh) 2005-09-09
NZ518156A (en) 2004-05-28
SK5062002A3 (en) 2002-11-06
HK1049003A1 (en) 2003-04-25
US7164017B2 (en) 2007-01-16
IL183852A0 (en) 2009-02-11
TR200201059T2 (tr) 2002-09-23
AP1536A (en) 2006-01-09
JP3973906B2 (ja) 2007-09-12
JP2006342182A (ja) 2006-12-21
HUP0204085A3 (en) 2006-01-30
AR026064A1 (es) 2002-12-26
NZ531260A (en) 2005-08-26
NO20021811D0 (no) 2002-04-17
IS8586A (is) 2006-12-27
US20030153564A1 (en) 2003-08-14
EP1235831B1 (en) 2005-03-30
US20060166979A1 (en) 2006-07-27
PT1235831E (pt) 2005-06-30
WO2001028992A2 (en) 2001-04-26
TWI283680B (en) 2007-07-11
US7351821B2 (en) 2008-04-01
AU1069101A (en) 2001-04-30
WO2001028992A3 (en) 2001-09-13
IL183853A0 (en) 2009-02-11
SE9903759D0 (sv) 1999-10-18
EE04854B1 (et) 2007-06-15
US20060166980A1 (en) 2006-07-27
US7772229B2 (en) 2010-08-10
OA12067A (en) 2006-05-04
CN100379743C (zh) 2008-04-09
IL149108A0 (en) 2002-11-10
DK1235831T3 (da) 2005-06-27

Similar Documents

Publication Publication Date Title
HUP0204085A2 (hu) Kardiális aritmiák kezelésében alkalmazható új oxa-biszpidin-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
BR9713552A (pt) Derivados de pirimidina bicìclicos condensados
MY132073A (en) Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
HUP0100669A2 (hu) Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
HUP0004040A1 (hu) Antimikrobiális hatású pleuromutilinszármazékok, eljárás ezek előállítására, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
CA2188283A1 (en) Substituted 1,3-oxathiolanes with antiviral properties
BG106013A (en) New compounds and compositions as protease inhibitors
MY130668A (en) Isothiazole derivatives useful as anticancer agents
HUP0203312A2 (hu) Farmakológiailag hatékony szulfonamidszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP9702345A2 (hu) 3-Hidroxi-piridin-2-karbonsav-amid-észter-származékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUT59417A (en) Process for producing azasteroid compounds and pharmaceutical compositions comprising same as active ingredient
LV12811B (en) Novel (r)-5-carbamoyl-8-fluoro-3-n,n-disubstituted-amino-3,4-dihydro-2h-1-benzopyranes
HUP0102466A2 (hu) Antiösztrogén hatású új benzo-pirán vagy tiobenzo-pirán származékok, eljárás előállításukra és azokat tartalmazó gyógyszerkészítmények
AU3850600A (en) Dalda analogs and their use
HUP0400494A2 (hu) Citotoxikus poliamin-analógok és ezeket tartalmazó gyógyszerkészítmények
MY129176A (en) Tetrahydro gamma-carbolines
MXPA02006249A (es) Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas.
CA2155323A1 (en) Novel use as anti-inflammatory agents for bis-heterocyclic compounds and pharmaceutical compositions thereof
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
HUP0102025A2 (hu) Diaril-1,3,4-oxadiazolon-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE69001722T2 (de) Entzuendungshemmende und/oder antiallergische zusammensetzung, die glutathionderivate enthaelt.
HUP9701660A2 (hu) 10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények
NO163488C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,5-benzothiazepin-derivater.
NZ510115A (en) Tricyclic delta3-piperidines as alpha2-antagonists useful in the treatment of depression and Parkinson's disease
HUP9904091A2 (hu) N-(Benzotiazol-2-il)-piperidin-1-etánamin-származékok, eljárás előállításukra és alkalmazásuk a gyógyászatban

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished