EA200200390A1 - Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий - Google Patents

Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий

Info

Publication number
EA200200390A1
EA200200390A1 EA200200390A EA200200390A EA200200390A1 EA 200200390 A1 EA200200390 A1 EA 200200390A1 EA 200200390 A EA200200390 A EA 200200390A EA 200200390 A EA200200390 A EA 200200390A EA 200200390 A1 EA200200390 A1 EA 200200390A1
Authority
EA
Eurasian Patent Office
Prior art keywords
useful
treatment
compounds
oxabispidic
arithmia
Prior art date
Application number
EA200200390A
Other languages
English (en)
Other versions
EA005319B1 (ru
Inventor
Анника Бьёре
Магнус Бьёрсне
Дейвид Клейдингбил
Курт-Йюрген Хоффман
Джон Пейви
Фритьоф Понтен
Ерт Страндлунд
Педер Свенссон
Колин Томсон
Микаэль Вильстерманн
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA200200390A1 publication Critical patent/EA200200390A1/ru
Publication of EA005319B1 publication Critical patent/EA005319B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Предложены соединения формулы (I), где R, R, R, R, радикалы от Rдо R, А, В и G имеют значения, приведенные в описании изобретения, которые полезны при профилактике и при лечении аритмий, в частности, предсердной и желудочковой аритмий.Отчет о международном поиске был опубликован 2001.09.13.
EA200200390A 1999-10-18 2000-10-13 Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий EA005319B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
EA200200390A1 true EA200200390A1 (ru) 2002-10-31
EA005319B1 EA005319B1 (ru) 2005-02-24

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200390A EA005319B1 (ru) 1999-10-18 2000-10-13 Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий

Country Status (41)

Country Link
US (6) US6559143B1 (ru)
EP (2) EP1559717A3 (ru)
JP (3) JP3973906B2 (ru)
KR (1) KR100796142B1 (ru)
CN (2) CN100379743C (ru)
AP (1) AP1536A (ru)
AR (2) AR026064A1 (ru)
AT (1) ATE292134T1 (ru)
AU (1) AU769513B2 (ru)
BG (1) BG65785B1 (ru)
BR (1) BR0014804A (ru)
CA (1) CA2386910A1 (ru)
CO (1) CO5271655A1 (ru)
CU (1) CU23210A3 (ru)
CZ (1) CZ20021328A3 (ru)
DE (1) DE60019158T2 (ru)
DK (1) DK1235831T3 (ru)
EA (1) EA005319B1 (ru)
EE (1) EE04854B1 (ru)
ES (1) ES2239047T3 (ru)
HK (1) HK1049003B (ru)
HR (1) HRP20020336B1 (ru)
HU (1) HUP0204085A3 (ru)
IL (5) IL149108A0 (ru)
IS (2) IS2224B (ru)
MX (1) MXPA02003848A (ru)
MY (1) MY130661A (ru)
NO (1) NO327977B1 (ru)
NZ (2) NZ518156A (ru)
OA (1) OA12067A (ru)
PL (1) PL354970A1 (ru)
PT (1) PT1235831E (ru)
RS (1) RS50760B (ru)
SE (1) SE9903759D0 (ru)
SI (1) SI1235831T1 (ru)
SK (1) SK286723B6 (ru)
TR (1) TR200201059T2 (ru)
TW (1) TWI283680B (ru)
UA (1) UA75052C2 (ru)
WO (1) WO2001028992A2 (ru)
ZA (1) ZA200202575B (ru)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
WO2003045956A1 (en) * 2001-11-22 2003-06-05 Astrazeneca Ab Process for the preparation of 2-or-9-oxa-3, 7-diazabicyclo (3.3.1) nonanes from 2-aminomethyl-2, 3-dihydrooxazines, intermediates therefore, and processes for preparing such intermediates
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
CN101243093A (zh) 2005-06-13 2008-08-13 阿斯利康(瑞典)有限公司 用于治疗心律不齐的新型氧杂双哌啶化合物
MX2007016498A (es) * 2005-06-20 2008-03-04 Astrazeneca Ab Proceso para la preparacion de 3,7-dihidroxi-1,5-diazaciclooctanos .
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
KR20080028435A (ko) * 2005-06-20 2008-03-31 아스트라제네카 아베 Ｎ,ｎ’-이치환된 옥사비스피딘의 제조 방법
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

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US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
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US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
RU2254333C2 (ru) 1999-04-09 2005-06-20 Астразенека Аб Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
EP1559717A3 (en) 2009-04-29
UA75052C2 (en) 2006-03-15
DE60019158D1 (de) 2005-05-04
PL354970A1 (en) 2004-03-22
HRP20020336B1 (en) 2006-02-28
IS6346A (is) 2002-04-17
HRP20020336A2 (en) 2004-02-29
SE9903759D0 (sv) 1999-10-18
IS8586A (is) 2006-12-27
EP1235831B1 (en) 2005-03-30
JP2006342182A (ja) 2006-12-21
KR20020038956A (ko) 2002-05-24
CN100379743C (zh) 2008-04-09
AP1536A (en) 2006-01-09
BG106588A (en) 2003-01-31
SK5062002A3 (en) 2002-11-06
EE04854B1 (et) 2007-06-15
EE200200203A (et) 2003-06-16
US20030153564A1 (en) 2003-08-14
TR200201059T2 (tr) 2002-09-23
IS2224B (is) 2007-04-15
HK1049003B (zh) 2005-09-09
YU29402A (sh) 2004-12-31
JP3973906B2 (ja) 2007-09-12
AR039226A2 (es) 2005-02-09
NZ518156A (en) 2004-05-28
AR026064A1 (es) 2002-12-26
JP2007204486A (ja) 2007-08-16
EP1559717A2 (en) 2005-08-03
JP2003512352A (ja) 2003-04-02
AP2002002471A0 (en) 2002-06-30
IL183854A0 (en) 2009-02-11
IL149108A (en) 2009-12-24
NO327977B1 (no) 2009-11-02
US20070117799A1 (en) 2007-05-24
WO2001028992A2 (en) 2001-04-26
ES2239047T3 (es) 2005-09-16
BG65785B1 (bg) 2009-11-30
IL149108A0 (en) 2002-11-10
HUP0204085A2 (hu) 2003-04-28
MXPA02003848A (es) 2002-10-23
DK1235831T3 (da) 2005-06-27
CO5271655A1 (es) 2003-04-30
SK286723B6 (sk) 2009-04-06
CZ20021328A3 (cs) 2002-09-11
US20060166979A1 (en) 2006-07-27
US20090326221A1 (en) 2009-12-31
PT1235831E (pt) 2005-06-30
NO20021811D0 (no) 2002-04-17
DE60019158T2 (de) 2006-02-02
ZA200202575B (en) 2003-09-23
SI1235831T1 (ru) 2005-08-31
IL183853A0 (en) 2009-02-11
RS50760B (sr) 2010-08-31
KR100796142B1 (ko) 2008-01-21
HK1049003A1 (en) 2003-04-25
NZ531260A (en) 2005-08-26
US6559143B1 (en) 2003-05-06
CN101265262A (zh) 2008-09-17
BR0014804A (pt) 2002-06-11
OA12067A (en) 2006-05-04
AU769513B2 (en) 2004-01-29
IL183852A0 (en) 2009-02-11
AU1069101A (en) 2001-04-30
HUP0204085A3 (en) 2006-01-30
EP1235831A2 (en) 2002-09-04
EA005319B1 (ru) 2005-02-24
NO20021811L (no) 2002-06-06
CN1399639A (zh) 2003-02-26
US7164017B2 (en) 2007-01-16
TWI283680B (en) 2007-07-11
CA2386910A1 (en) 2001-04-26
US20060166980A1 (en) 2006-07-27
WO2001028992A3 (en) 2001-09-13
US7351821B2 (en) 2008-04-01
MY130661A (en) 2007-07-31
CU23210A3 (es) 2007-06-20
ATE292134T1 (de) 2005-04-15
US7772229B2 (en) 2010-08-10

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU