YU29402A - Nova jedinjenja oksabispidina korisna u lečenju srčanih aritmija - Google Patents

Nova jedinjenja oksabispidina korisna u lečenju srčanih aritmija

Info

Publication number
YU29402A
YU29402A YU29402A YUP29402A YU29402A YU 29402 A YU29402 A YU 29402A YU 29402 A YU29402 A YU 29402A YU P29402 A YUP29402 A YU P29402A YU 29402 A YU29402 A YU 29402A
Authority
YU
Yugoslavia
Prior art keywords
treatment
compounds useful
cardiac arrhythmias
oxabispidine compounds
new
Prior art date
Application number
YU29402A
Other languages
English (en)
Inventor
Annika Bjore
Magnus Bjorsne
David Clading-Boel
Kurt-Jurgen Hoffmann
John Pavey
Fritiof Ponten
Gert Strandlund
Peder Svensson
Colin Thomson
Michael Wilsterman
Original Assignee
Astrazeneca Ab.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab. filed Critical Astrazeneca Ab.
Publication of YU29402A publication Critical patent/YU29402A/sh
Publication of RS50760B publication Critical patent/RS50760B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Obezbedjena su jedinjenja formule (I) gde R1, R2, R3, R4, R41 do R46, A, B i G imaju značenja data u opisu i koja su korisna u profilaksi i lečenju aritmije naročito artrijalnih i ventikularnih aritmija.[There is provided compounds of formula (I), wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
YUP-294/02A 1999-10-18 2000-10-13 Nova jedinjenja oksabispidina korisna u lečenju srčanih aritmija RS50760B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
YU29402A true YU29402A (sh) 2004-12-31
RS50760B RS50760B (sr) 2010-08-31

Family

ID=20417401

Country Status (41)

Country Link
US (6) US6559143B1 (sh)
EP (2) EP1235831B1 (sh)
JP (3) JP3973906B2 (sh)
KR (1) KR100796142B1 (sh)
CN (2) CN101265262A (sh)
AP (1) AP1536A (sh)
AR (2) AR026064A1 (sh)
AT (1) ATE292134T1 (sh)
AU (1) AU769513B2 (sh)
BG (1) BG65785B1 (sh)
BR (1) BR0014804A (sh)
CA (1) CA2386910A1 (sh)
CO (1) CO5271655A1 (sh)
CU (1) CU23210A3 (sh)
CZ (1) CZ20021328A3 (sh)
DE (1) DE60019158T2 (sh)
DK (1) DK1235831T3 (sh)
EA (1) EA005319B1 (sh)
EE (1) EE04854B1 (sh)
ES (1) ES2239047T3 (sh)
HK (1) HK1049003B (sh)
HR (1) HRP20020336B1 (sh)
HU (1) HUP0204085A3 (sh)
IL (5) IL149108A0 (sh)
IS (2) IS2224B (sh)
MX (1) MXPA02003848A (sh)
MY (1) MY130661A (sh)
NO (1) NO327977B1 (sh)
NZ (2) NZ531260A (sh)
OA (1) OA12067A (sh)
PL (1) PL354970A1 (sh)
PT (1) PT1235831E (sh)
RS (1) RS50760B (sh)
SE (1) SE9903759D0 (sh)
SI (1) SI1235831T1 (sh)
SK (1) SK286723B6 (sh)
TR (1) TR200201059T2 (sh)
TW (1) TWI283680B (sh)
UA (1) UA75052C2 (sh)
WO (1) WO2001028992A2 (sh)
ZA (1) ZA200202575B (sh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
JP2005514376A (ja) * 2001-11-22 2005-05-19 アストラゼネカ アクチボラグ ２−アミノメチル−２，３−ジヒドロオキサジンからの２−又は−９−オキサ−３，７−ジアザビシクロ（３．３．１）ノナンの調製のための方法、その中間体、及びこのような中間体を調製するための方法
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
WO2006135316A1 (en) * 2005-06-13 2006-12-21 Astrazeneca Ab New oxabispidine compounds for the treatment of cardiac arrhythmias
AU2006259938B2 (en) * 2005-06-20 2010-07-01 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
AR057363A1 (es) * 2005-06-20 2007-11-28 Astrazeneca Ab Proceso para la preparacion de oxabispidinas n,n'-disustituidas
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
WO2016054123A1 (en) 2014-09-30 2016-04-07 Lightner Derek Methods of producing heteropolycycles via bis-epoxidation

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US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
JPS6284070A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
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US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
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SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
JP2002541249A (ja) 1999-04-09 2002-12-03 アストラゼネカ・アクチエボラーグ アダマンタン誘導体
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
US20030153564A1 (en) 2003-08-14
HK1049003B (zh) 2005-09-09
IL183854A0 (en) 2009-02-11
US7164017B2 (en) 2007-01-16
EA005319B1 (ru) 2005-02-24
NO20021811D0 (no) 2002-04-17
EP1235831A2 (en) 2002-09-04
TWI283680B (en) 2007-07-11
ATE292134T1 (de) 2005-04-15
WO2001028992A2 (en) 2001-04-26
AU1069101A (en) 2001-04-30
HK1049003A1 (en) 2003-04-25
CA2386910A1 (en) 2001-04-26
AP1536A (en) 2006-01-09
CN101265262A (zh) 2008-09-17
IL183853A0 (en) 2009-02-11
EE04854B1 (et) 2007-06-15
BG106588A (en) 2003-01-31
AR026064A1 (es) 2002-12-26
AU769513B2 (en) 2004-01-29
JP2003512352A (ja) 2003-04-02
US20070117799A1 (en) 2007-05-24
CN100379743C (zh) 2008-04-09
AR039226A2 (es) 2005-02-09
DE60019158T2 (de) 2006-02-02
US7351821B2 (en) 2008-04-01
OA12067A (en) 2006-05-04
US20060166980A1 (en) 2006-07-27
UA75052C2 (en) 2006-03-15
BR0014804A (pt) 2002-06-11
US20060166979A1 (en) 2006-07-27
HUP0204085A2 (hu) 2003-04-28
MY130661A (en) 2007-07-31
SK5062002A3 (en) 2002-11-06
JP3973906B2 (ja) 2007-09-12
BG65785B1 (bg) 2009-11-30
IL149108A0 (en) 2002-11-10
HRP20020336B1 (en) 2006-02-28
CZ20021328A3 (cs) 2002-09-11
TR200201059T2 (tr) 2002-09-23
IL149108A (en) 2009-12-24
DK1235831T3 (da) 2005-06-27
PL354970A1 (en) 2004-03-22
CU23210A3 (es) 2007-06-20
IS8586A (is) 2006-12-27
ZA200202575B (en) 2003-09-23
HUP0204085A3 (en) 2006-01-30
JP2006342182A (ja) 2006-12-21
MXPA02003848A (es) 2002-10-23
EE200200203A (et) 2003-06-16
IS2224B (is) 2007-04-15
NZ531260A (en) 2005-08-26
IS6346A (is) 2002-04-17
DE60019158D1 (de) 2005-05-04
SI1235831T1 (sh) 2005-08-31
KR100796142B1 (ko) 2008-01-21
AP2002002471A0 (en) 2002-06-30
NO20021811L (no) 2002-06-06
CN1399639A (zh) 2003-02-26
HRP20020336A2 (en) 2004-02-29
US7772229B2 (en) 2010-08-10
EP1559717A3 (en) 2009-04-29
RS50760B (sr) 2010-08-31
SE9903759D0 (sv) 1999-10-18
EP1235831B1 (en) 2005-03-30
US20090326221A1 (en) 2009-12-31
CO5271655A1 (es) 2003-04-30
SK286723B6 (sk) 2009-04-06
NO327977B1 (no) 2009-11-02
EA200200390A1 (ru) 2002-10-31
US6559143B1 (en) 2003-05-06
KR20020038956A (ko) 2002-05-24
ES2239047T3 (es) 2005-09-16
IL183852A0 (en) 2009-02-11
EP1559717A2 (en) 2005-08-03
JP2007204486A (ja) 2007-08-16
NZ518156A (en) 2004-05-28
PT1235831E (pt) 2005-06-30
WO2001028992A3 (en) 2001-09-13

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