NZ516013A - New bispidine compounds useful in the treatment of cardiac arrhythmias - Google Patents

New bispidine compounds useful in the treatment of cardiac arrhythmias

Info

Publication number
NZ516013A
NZ516013A NZ516013A NZ51601300A NZ516013A NZ 516013 A NZ516013 A NZ 516013A NZ 516013 A NZ516013 A NZ 516013A NZ 51601300 A NZ51601300 A NZ 51601300A NZ 516013 A NZ516013 A NZ 516013A
Authority
NZ
New Zealand
Prior art keywords
treatment
compounds useful
cardiac arrhythmias
bispidine compounds
new
Prior art date
Application number
NZ516013A
Inventor
Christer Alstermark
Kjell Andersson
Annika Bjore
Magnus Bjorsne
Alstermark Eva-Lotte Lindstedt
Goran Nilsson
Magnus Polla
Gert Strandlund
Ylva Ortengren
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NZ516013A publication Critical patent/NZ516013A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

There is provided compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43, R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
NZ516013A 1999-06-16 2000-06-15 New bispidine compounds useful in the treatment of cardiac arrhythmias NZ516013A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9902268A SE9902268D0 (en) 1999-06-16 1999-06-16 Pharmaceutically active compounds
PCT/SE2000/001254 WO2000077000A1 (en) 1999-06-16 2000-06-15 New bispidine compounds useful in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
NZ516013A true NZ516013A (en) 2003-06-30

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ516013A NZ516013A (en) 1999-06-16 2000-06-15 New bispidine compounds useful in the treatment of cardiac arrhythmias

Country Status (24)

Country Link
EP (1) EP1192157A1 (en)
JP (1) JP2003502329A (en)
KR (1) KR20020010713A (en)
CN (1) CN1144805C (en)
AR (1) AR024577A1 (en)
AU (1) AU761576B2 (en)
BR (1) BR0011660A (en)
CA (1) CA2375841A1 (en)
CZ (1) CZ20014495A3 (en)
EE (1) EE200100675A (en)
HK (1) HK1045520A1 (en)
HU (1) HUP0203959A3 (en)
IL (1) IL146754A0 (en)
IS (1) IS6201A (en)
MX (1) MXPA01012919A (en)
NO (1) NO20016117L (en)
NZ (1) NZ516013A (en)
PL (1) PL354032A1 (en)
RU (1) RU2250903C2 (en)
SE (1) SE9902268D0 (en)
SK (1) SK18272001A3 (en)
TR (1) TR200103663T2 (en)
WO (1) WO2000077000A1 (en)
ZA (1) ZA200109796B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (en) * 2000-07-07 2003-08-20 Astrazeneca Ab BISPIDINE COMPOUNDS, PHARMACEUTICAL FORMULATION, USE FOR THE MANUFACTURE OF MEDICINES, PROCESS FOR THE PREPARATION OF THESE INTERMEDIATE COMPOUNDS AND COMPOUNDS
SE0101327D0 (en) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (en) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl Isoquinolin-1(2h)-one derivatives
ES2648308T3 (en) * 2011-07-08 2017-12-29 Bayer Intellectual Property Gmbh Procedure for the preparation of 2-amino-5-cyano-N, 3-dimethylbenzamide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88381B (en) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh PROCESS FOR THE PREPARATION OF NEW COMPOUNDS 3,7-DIAZABICYCLO (3,3,1) NONANO, AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE3732094A1 (en) * 1987-09-24 1989-04-06 Basf Ag BISPID DERIVATIVES AS CLASS III ANTIARRHYTHMICS
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (en) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
JP2003502329A (en) 2003-01-21
NO20016117L (en) 2002-02-15
IL146754A0 (en) 2002-07-25
AU6032400A (en) 2001-01-02
CN1370167A (en) 2002-09-18
BR0011660A (en) 2002-03-26
WO2000077000A1 (en) 2000-12-21
TR200103663T2 (en) 2002-05-21
PL354032A1 (en) 2003-12-15
KR20020010713A (en) 2002-02-04
HUP0203959A2 (en) 2003-03-28
MXPA01012919A (en) 2002-07-30
RU2250903C2 (en) 2005-04-27
AR024577A1 (en) 2002-10-16
SK18272001A3 (en) 2002-12-03
CN1144805C (en) 2004-04-07
IS6201A (en) 2001-12-14
SE9902268D0 (en) 1999-06-16
NO20016117D0 (en) 2001-12-14
ZA200109796B (en) 2003-02-28
WO2000077000A9 (en) 2003-06-19
EE200100675A (en) 2003-02-17
HUP0203959A3 (en) 2003-04-28
AU761576B2 (en) 2003-06-05
CZ20014495A3 (en) 2002-05-15
HK1045520A1 (en) 2002-11-29
EP1192157A1 (en) 2002-04-03
CA2375841A1 (en) 2000-12-21

Similar Documents

Publication Publication Date Title
AP1536A (en) New oxabispidine compounds useful in the treatment of cardiac arrhythmias.
SE9704709D0 (en) Pharmaceutically active compounds
JO2256B1 (en) Renin inhibitors
PL341364A1 (en) 4-hydroxyqinoline-3-carboxamides and hydrazides as antiviral agents
NO983074L (en) Carbamoyloxy derivatives of mutilin and their use as antibacterial agents
NZ529682A (en) Biologically active methylene blue derivatives
CA2120303A1 (en) Cyclic adhesion inhibitors
CA2370244A1 (en) Piperidine derivatives
BG106524A (en) Piperidine quinolyl propyl derivatives and their use as antibacterial means
CA2367704A1 (en) Pyrazolobenzodiazepines as cdk2 inhibitors
MY133785A (en) Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias
MY136788A (en) 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment or cardiac arrhythmias
CA2280727A1 (en) Bicyclic amino acids
TW200612907A (en) New compounds
NZ516013A (en) New bispidine compounds useful in the treatment of cardiac arrhythmias
UA85232C2 (en) Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias
SE0003795D0 (en) Pharmaceutically useful compounds
IL81337A0 (en) Heptanoyl-glu-asp-ala-amino acid immunostimulants
DE69516519T2 (en) ACTIVE AGAINST ARTERIOSCLEROSIS
TR200103659T2 (en) New bispidin compounds useful in the treatment of cardiac arrhythmias.
TR200103660T2 (en) New bispidin compounds useful in the treatment of cardiac arrhythmias
SE9902269D0 (en) Pharmaceutically active compounds
SE0002603D0 (en) New compounds
YU55798A (en) The novel n-(4-carbamimidophenylamino) phenylglycineamide
WO1999010371A3 (en) Cyclopeptide derivatives as adhesion inhibitors

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)