CA2280727A1 - Bicyclic amino acids - Google Patents
Bicyclic amino acids Download PDFInfo
- Publication number
- CA2280727A1 CA2280727A1 CA002280727A CA2280727A CA2280727A1 CA 2280727 A1 CA2280727 A1 CA 2280727A1 CA 002280727 A CA002280727 A CA 002280727A CA 2280727 A CA2280727 A CA 2280727A CA 2280727 A1 CA2280727 A1 CA 2280727A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acids
- compounds
- bicyclic amino
- diseases
- infarcts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Bicyclic amino acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000000644 propagated effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to compounds of formula (1), wherein X, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meaning cited in Claim 1, and to their physiologically acceptable salts. Said compounds can be used as integrin inhibitors, specially for prophylaxis and treatment of circulatory diseases, thrombosis, infarcts, coronary heart diseases, arteriosclerosis, osteoporosis, pathological symptoms sustained or propagated by angiogenesis and in tumor therapy.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19705450.1 | 1997-02-13 | ||
DE19705450A DE19705450A1 (en) | 1997-02-13 | 1997-02-13 | Bicyclic aromatic amino acids |
PCT/EP1998/000636 WO1998035949A1 (en) | 1997-02-13 | 1998-02-06 | Bicyclic amino acids |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2280727A1 true CA2280727A1 (en) | 1998-08-20 |
CA2280727C CA2280727C (en) | 2008-05-06 |
Family
ID=7820093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002280727A Expired - Fee Related CA2280727C (en) | 1997-02-13 | 1998-02-06 | Bicyclic amino acids |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0964856B1 (en) |
JP (1) | JP4327257B2 (en) |
KR (1) | KR20000071030A (en) |
CN (1) | CN1085205C (en) |
AR (1) | AR010894A1 (en) |
AT (1) | ATE225776T1 (en) |
AU (1) | AU735313B2 (en) |
BR (1) | BR9807345A (en) |
CA (1) | CA2280727C (en) |
CY (1) | CY2341B1 (en) |
CZ (1) | CZ297366B6 (en) |
DE (2) | DE19705450A1 (en) |
DK (1) | DK0964856T3 (en) |
ES (1) | ES2183332T3 (en) |
HU (1) | HUP0001138A3 (en) |
ID (1) | ID22533A (en) |
NO (1) | NO313289B1 (en) |
PL (1) | PL335101A1 (en) |
PT (1) | PT964856E (en) |
RU (1) | RU2187506C2 (en) |
SI (1) | SI0964856T1 (en) |
SK (1) | SK284646B6 (en) |
TR (1) | TR199901962T2 (en) |
WO (1) | WO1998035949A1 (en) |
ZA (1) | ZA981178B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9303018B2 (en) | 2013-07-15 | 2016-04-05 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US9573957B2 (en) | 2013-07-15 | 2017-02-21 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US9662339B2 (en) | 2012-03-06 | 2017-05-30 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production for combination therapy |
US11957671B2 (en) | 2021-11-01 | 2024-04-16 | Alkahest, Inc. | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
NZ507222A (en) | 1998-04-09 | 2003-05-30 | Meiji Seika Kaisha | Aminopiperidine derivatives useful as integrin antagonists |
CZ20013678A3 (en) | 1999-04-13 | 2002-07-17 | Basf Aktiengesellschaft | Ligands of integrin receptor |
WO2001010844A1 (en) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM |
US20030199571A1 (en) * | 1999-12-24 | 2003-10-23 | Gordon Bruton | (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives |
EP1170287B1 (en) * | 2000-01-25 | 2003-12-03 | Kaneka Corporation | Process for preparation of optically active n-substituted azetidine-2-carboxylic acids |
DK1381382T3 (en) | 2000-11-01 | 2009-02-02 | Merck Patent Gmbh | Methods and Preparations for the Treatment of Eye Diseases |
CA2449054C (en) | 2001-05-30 | 2011-01-04 | The Scripps Research Institute | Integrin targeting liposome for nucleic acid delivery |
MXPA04000839A (en) * | 2001-08-01 | 2004-05-14 | Merck Patent Gesellscahft Mit | Integrin inhibitors for the treatment of eye diseases. |
MXPA04007770A (en) * | 2002-02-14 | 2004-10-15 | Merck Patent Gmbh | Methods and compositions for the treatment of eye diseases. |
DE10305784A1 (en) * | 2003-02-12 | 2004-08-26 | Merck Patent Gmbh | 3-Oxo-3,4-dihydro-2H-benz-(1,4)-oxazin-6-yl)-propionic acid derivative preparation, for use as integrin inhibitors with e.g. antitumor action, by multi-stage process giving diastereomerically pure product |
DE10337863A1 (en) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Use of chromene-4-one derivatives |
KR101224368B1 (en) * | 2004-06-04 | 2013-01-22 | 더 스크립스 리서치 인스티튜트 | Compositions and methods for treatment of neovascular diseases |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
AU2009331179B2 (en) * | 2008-12-26 | 2014-09-18 | Sumitomo Pharma Co., Ltd. | Novel bicyclic heterocyclic compound |
WO2011024987A1 (en) * | 2009-08-31 | 2011-03-03 | 塩野義製薬株式会社 | Aromatic fused heterocyclic derivative and pharmaceutical composition containing same |
WO2015181676A1 (en) | 2014-05-30 | 2015-12-03 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2150550A1 (en) * | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
US5741796A (en) * | 1994-05-27 | 1998-04-21 | Merck & Co., Inc. | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption |
DE19548709A1 (en) * | 1995-12-23 | 1997-07-03 | Merck Patent Gmbh | Tyrosine derivatives |
DE19654483A1 (en) * | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanine derivatives |
EP0907637A1 (en) * | 1996-06-28 | 1999-04-14 | MERCK PATENT GmbH | Phenylalamine derivatives as integrin inhibitors |
-
1997
- 1997-02-13 DE DE19705450A patent/DE19705450A1/en not_active Withdrawn
-
1998
- 1998-02-06 TR TR1999/01962T patent/TR199901962T2/en unknown
- 1998-02-06 DE DE59805895T patent/DE59805895D1/en not_active Expired - Lifetime
- 1998-02-06 AU AU66206/98A patent/AU735313B2/en not_active Ceased
- 1998-02-06 KR KR1019997007297A patent/KR20000071030A/en not_active Application Discontinuation
- 1998-02-06 WO PCT/EP1998/000636 patent/WO1998035949A1/en active IP Right Grant
- 1998-02-06 DK DK98908063T patent/DK0964856T3/en active
- 1998-02-06 SK SK1071-99A patent/SK284646B6/en unknown
- 1998-02-06 JP JP53530398A patent/JP4327257B2/en not_active Expired - Fee Related
- 1998-02-06 BR BR9807345A patent/BR9807345A/en not_active Application Discontinuation
- 1998-02-06 HU HU0001138A patent/HUP0001138A3/en unknown
- 1998-02-06 RU RU99119223/04A patent/RU2187506C2/en not_active IP Right Cessation
- 1998-02-06 PT PT98908063T patent/PT964856E/en unknown
- 1998-02-06 CA CA002280727A patent/CA2280727C/en not_active Expired - Fee Related
- 1998-02-06 SI SI9830304T patent/SI0964856T1/en unknown
- 1998-02-06 AT AT98908063T patent/ATE225776T1/en not_active IP Right Cessation
- 1998-02-06 ID IDW990812A patent/ID22533A/en unknown
- 1998-02-06 ES ES98908063T patent/ES2183332T3/en not_active Expired - Lifetime
- 1998-02-06 PL PL98335101A patent/PL335101A1/en unknown
- 1998-02-06 CN CN98803959A patent/CN1085205C/en not_active Expired - Fee Related
- 1998-02-06 EP EP98908063A patent/EP0964856B1/en not_active Expired - Lifetime
- 1998-02-06 CZ CZ0287599A patent/CZ297366B6/en not_active IP Right Cessation
- 1998-02-12 ZA ZA981178A patent/ZA981178B/en unknown
- 1998-02-13 AR ARP980100654A patent/AR010894A1/en not_active Application Discontinuation
-
1999
- 1999-08-12 NO NO19993901A patent/NO313289B1/en not_active IP Right Cessation
-
2003
- 2003-03-17 CY CY0300028A patent/CY2341B1/en unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9662339B2 (en) | 2012-03-06 | 2017-05-30 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production for combination therapy |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US9303018B2 (en) | 2013-07-15 | 2016-04-05 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US9573957B2 (en) | 2013-07-15 | 2017-02-21 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
US11957671B2 (en) | 2021-11-01 | 2024-04-16 | Alkahest, Inc. | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2280727A1 (en) | Bicyclic amino acids | |
TW372232B (en) | Phenylalanine derivatives | |
RU94013439A (en) | HETEROCYCLIC COMPOUNDS, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT | |
NO986090L (en) | Phenylalanine derivatives as integrin inhibitors | |
UA74346C2 (en) | Aminodicarboxylic acids derivatives, use thereof and a medicament | |
CA2400217A1 (en) | Pteridine compounds for the treatment of psoriasis | |
RU92004368A (en) | SUBSTITUTED PYRIMIDINES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION | |
FI913478A0 (en) | DIAZINDERIVAT. | |
CA2348391A1 (en) | Chromenone and chromanone derivatives as integrin inhibitors | |
HUT63422A (en) | Process for producing triazolopyrimidine derivatives and pharmaceutical compositions comprising same | |
EE03262B1 (en) | Alkoxyalkylcarbamates from Imidazo [1,2-a] pyridines, their Preparation and Use | |
EP0434057A3 (en) | Indolocarbazole derivatives, processes for their preparation and their use | |
EE200200305A (en) | Novel azabicyclooctane derivatives used in the treatment of cardiac arrhythmias | |
WO2000048996A3 (en) | β-ALANINE DERIVATIVES | |
HUP0103712A2 (en) | Salts of paroxetine, process for their preparation and their pharmaceutical use | |
DE69621786D1 (en) | AMINOTETRAL IN DERIVATIVE FOR THE TREATMENT OF HEART CIRCULAR DISEASE | |
HK1050141A1 (en) | Inhibitor for 20-hete-yielding enzyme | |
ATE554764T1 (en) | EFFECTIVE SIMPLIFIED DERIVATIVES OF IMMUNOSUPPRESSANTS | |
MX9604019A (en) | Biothyne derivatives. | |
HUP0303181A2 (en) | Use of type 4 phosphodiesterase inhibitors for preparation of pharmaceutical compositions suitable for treating of myocardial diseases | |
WO1998056759A3 (en) | Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same | |
MX9600165A (en) | 3-alkoxycarbonylthiadiazinonas, process for the preparation thereof and pharmaceutical compositions containing them. | |
WO2001010841A3 (en) | Fluorene derivatives as integrin inhibitors | |
WO2001021620A3 (en) | Amine derivatives of benzo-4,5-thieno-2,3-d pyrimidines | |
HUP0301971A3 (en) | Uses of thaliporphine or its derivatives for producing pharmaceutical compositions suitable for treating cardiac diseases and the compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140206 |