WO1999010371A3 - Cyclopeptide derivatives as adhesion inhibitors - Google Patents

Cyclopeptide derivatives as adhesion inhibitors Download PDF

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Publication number
WO1999010371A3
WO1999010371A3 PCT/EP1998/005161 EP9805161W WO9910371A3 WO 1999010371 A3 WO1999010371 A3 WO 1999010371A3 EP 9805161 W EP9805161 W EP 9805161W WO 9910371 A3 WO9910371 A3 WO 9910371A3
Authority
WO
WIPO (PCT)
Prior art keywords
adhesion inhibitors
cyclopeptide derivatives
diseases
cyclopeptide
derivatives
Prior art date
Application number
PCT/EP1998/005161
Other languages
German (de)
French (fr)
Other versions
WO1999010371A2 (en
Inventor
Guenter Hoelzemann
Simon Goodman
Original Assignee
Merck Patent Gmbh
Guenter Hoelzemann
Simon Goodman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Guenter Hoelzemann, Simon Goodman filed Critical Merck Patent Gmbh
Priority to EP98948833A priority Critical patent/EP1007545A2/en
Priority to CA002301182A priority patent/CA2301182A1/en
Priority to PL98341090A priority patent/PL341090A1/en
Priority to KR1020007001430A priority patent/KR20010022828A/en
Priority to BR9811992-3A priority patent/BR9811992A/en
Priority to AU95319/98A priority patent/AU734829B2/en
Priority to JP2000507697A priority patent/JP2001514186A/en
Priority to SK213-2000A priority patent/SK2132000A3/en
Publication of WO1999010371A2 publication Critical patent/WO1999010371A2/en
Publication of WO1999010371A3 publication Critical patent/WO1999010371A3/en
Priority to NO20000860A priority patent/NO20000860L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of formula (I), in which X, A, B and C have the meanings given in Claim 1, as well as their salts, can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, in pathological conditions maintained and propagated by angiogenesis, and for tumour therapy.
PCT/EP1998/005161 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors WO1999010371A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP98948833A EP1007545A2 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors
CA002301182A CA2301182A1 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives
PL98341090A PL341090A1 (en) 1997-08-23 1998-08-14 Cyclic derivatives of peptides as adhesion inhibitors
KR1020007001430A KR20010022828A (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors
BR9811992-3A BR9811992A (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives
AU95319/98A AU734829B2 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives
JP2000507697A JP2001514186A (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors
SK213-2000A SK2132000A3 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors
NO20000860A NO20000860L (en) 1997-08-23 2000-02-22 Cyclopeptide derivatives as adhesion inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19736772A DE19736772A1 (en) 1997-08-23 1997-08-23 New guanidino-substituted bi:cyclic peptide compounds
DE19736772.0 1997-08-23

Publications (2)

Publication Number Publication Date
WO1999010371A2 WO1999010371A2 (en) 1999-03-04
WO1999010371A3 true WO1999010371A3 (en) 1999-05-27

Family

ID=7839977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005161 WO1999010371A2 (en) 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors

Country Status (18)

Country Link
EP (1) EP1007545A2 (en)
JP (1) JP2001514186A (en)
KR (1) KR20010022828A (en)
CN (1) CN1267306A (en)
AR (1) AR013650A1 (en)
AU (1) AU734829B2 (en)
BR (1) BR9811992A (en)
CA (1) CA2301182A1 (en)
DE (1) DE19736772A1 (en)
HU (1) HUP0003500A3 (en)
ID (1) ID23952A (en)
NO (1) NO20000860L (en)
PL (1) PL341090A1 (en)
RU (1) RU2200166C2 (en)
SK (1) SK2132000A3 (en)
TW (1) TW477793B (en)
WO (1) WO1999010371A2 (en)
ZA (1) ZA987558B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578083A2 (en) * 1992-07-06 1994-01-12 MERCK PATENT GmbH Cyclic adhesion inhibitors
DE4310643A1 (en) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclic adhesion inhibitors
DE4415310A1 (en) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptides
JPH07316193A (en) * 1994-05-24 1995-12-05 Asahi Glass Co Ltd Peptide derivative and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578083A2 (en) * 1992-07-06 1994-01-12 MERCK PATENT GmbH Cyclic adhesion inhibitors
DE4310643A1 (en) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclic adhesion inhibitors
DE4415310A1 (en) * 1994-04-30 1995-11-02 Merck Patent Gmbh Cyclopeptides
JPH07316193A (en) * 1994-05-24 1995-12-05 Asahi Glass Co Ltd Peptide derivative and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9606, Derwent World Patents Index; Class B04, AN 96-055984, XP002091715 *

Also Published As

Publication number Publication date
NO20000860D0 (en) 2000-02-22
EP1007545A2 (en) 2000-06-14
CN1267306A (en) 2000-09-20
NO20000860L (en) 2000-02-22
ZA987558B (en) 1999-02-23
HUP0003500A2 (en) 2001-02-28
AU734829B2 (en) 2001-06-21
AR013650A1 (en) 2001-01-10
AU9531998A (en) 1999-03-16
CA2301182A1 (en) 1999-03-04
SK2132000A3 (en) 2000-09-12
ID23952A (en) 2000-06-08
PL341090A1 (en) 2001-03-26
KR20010022828A (en) 2001-03-26
DE19736772A1 (en) 1999-02-25
BR9811992A (en) 2000-09-05
HUP0003500A3 (en) 2001-12-28
RU2200166C2 (en) 2003-03-10
JP2001514186A (en) 2001-09-11
TW477793B (en) 2002-03-01
WO1999010371A2 (en) 1999-03-04

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