BR0011660A - Compound, pharmaceutical formulation, use of a compound, prophylaxis method or treatment of an arrhythmia and, process for the preparation of a compound - Google Patents

Compound, pharmaceutical formulation, use of a compound, prophylaxis method or treatment of an arrhythmia and, process for the preparation of a compound

Info

Publication number
BR0011660A
BR0011660A BR0011660-2A BR0011660A BR0011660A BR 0011660 A BR0011660 A BR 0011660A BR 0011660 A BR0011660 A BR 0011660A BR 0011660 A BR0011660 A BR 0011660A
Authority
BR
Brazil
Prior art keywords
compound
treatment
preparation
pharmaceutical formulation
arrhythmia
Prior art date
Application number
BR0011660-2A
Other languages
Portuguese (pt)
Inventor
Christer Alstermark
Kjell Andersson
Annika Bjore
Magnus Bjorsne
Eva-Lotte Lindstedt Alstermark
G0Ran Nilsson
Magnus Polla
Gert Strandlund
Ylva Irtengren
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0011660A publication Critical patent/BR0011660A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTO, FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, MéTODO DE PROFILAXIA OU TRATAMENTO DE UMA ARRITMIA E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". São fornecidos os compostos da fórmula (I), em que R^ 1^, R^ 2^, R^ 3^, R ^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 41^, R^ 42^, R^ 43^, R^ 44^, R^ 45^, R^ 46^, A e B têm os significados dados no relatório descritivo, que são úteis na profilaxia e no tratamento de arritmias, em particular nas arritmias atriais e ventriculares."COMPOUND, PHARMACEUTICAL FORMULATION, USE OF A COMPOUND, PROPHYLAXY METHOD OR TREATMENT OF ARRYTHMIA AND PROCESS FOR THE PREPARATION OF A COMPOUND". The compounds of formula (I) are provided, in which R ^ 1 ^, R ^ 2 ^, R ^ 3 ^, R ^ 4 ^, R ^ 5 ^, R ^ 6 ^, R ^ 7 ^, R ^ 41 ^, R ^ 42 ^, R ^ 43 ^, R ^ 44 ^, R ^ 45 ^, R ^ 46 ^, A and B have the meanings given in the specification, which are useful in the prophylaxis and treatment of arrhythmias, in particularly in atrial and ventricular arrhythmias.

BR0011660-2A 1999-06-16 2000-06-15 Compound, pharmaceutical formulation, use of a compound, prophylaxis method or treatment of an arrhythmia and, process for the preparation of a compound BR0011660A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9902268A SE9902268D0 (en) 1999-06-16 1999-06-16 Pharmaceutically active compounds
PCT/SE2000/001254 WO2000077000A1 (en) 1999-06-16 2000-06-15 New bispidine compounds useful in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
BR0011660A true BR0011660A (en) 2002-03-26

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011660-2A BR0011660A (en) 1999-06-16 2000-06-15 Compound, pharmaceutical formulation, use of a compound, prophylaxis method or treatment of an arrhythmia and, process for the preparation of a compound

Country Status (24)

Country Link
EP (1) EP1192157A1 (en)
JP (1) JP2003502329A (en)
KR (1) KR20020010713A (en)
CN (1) CN1144805C (en)
AR (1) AR024577A1 (en)
AU (1) AU761576B2 (en)
BR (1) BR0011660A (en)
CA (1) CA2375841A1 (en)
CZ (1) CZ20014495A3 (en)
EE (1) EE200100675A (en)
HK (1) HK1045520A1 (en)
HU (1) HUP0203959A3 (en)
IL (1) IL146754A0 (en)
IS (1) IS6201A (en)
MX (1) MXPA01012919A (en)
NO (1) NO20016117L (en)
NZ (1) NZ516013A (en)
PL (1) PL354032A1 (en)
RU (1) RU2250903C2 (en)
SE (1) SE9902268D0 (en)
SK (1) SK18272001A3 (en)
TR (1) TR200103663T2 (en)
WO (1) WO2000077000A1 (en)
ZA (1) ZA200109796B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (en) * 2000-07-07 2003-08-20 Astrazeneca Ab BISPIDINE COMPOUNDS, PHARMACEUTICAL FORMULATION, USE FOR THE MANUFACTURE OF MEDICINES, PROCESS FOR THE PREPARATION OF THESE INTERMEDIATE COMPOUNDS AND COMPOUNDS
SE0101327D0 (en) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (en) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl Isoquinolin-1(2h)-one derivatives
US9169198B2 (en) * 2011-07-08 2015-10-27 Bayer Intellectual Property Gmbh Method for the production of 2-amino-5-cyano-N,3-dimethylbenzamide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88381B (en) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh PROCESS FOR THE PREPARATION OF NEW COMPOUNDS 3,7-DIAZABICYCLO (3,3,1) NONANO, AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE3732094A1 (en) * 1987-09-24 1989-04-06 Basf Ag BISPID DERIVATIVES AS CLASS III ANTIARRHYTHMICS
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (en) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
RU2250903C2 (en) 2005-04-27
WO2000077000A9 (en) 2003-06-19
JP2003502329A (en) 2003-01-21
AU6032400A (en) 2001-01-02
SE9902268D0 (en) 1999-06-16
SK18272001A3 (en) 2002-12-03
AU761576B2 (en) 2003-06-05
CN1370167A (en) 2002-09-18
ZA200109796B (en) 2003-02-28
NZ516013A (en) 2003-06-30
PL354032A1 (en) 2003-12-15
NO20016117L (en) 2002-02-15
HUP0203959A3 (en) 2003-04-28
CN1144805C (en) 2004-04-07
EP1192157A1 (en) 2002-04-03
CA2375841A1 (en) 2000-12-21
CZ20014495A3 (en) 2002-05-15
TR200103663T2 (en) 2002-05-21
NO20016117D0 (en) 2001-12-14
MXPA01012919A (en) 2002-07-30
HUP0203959A2 (en) 2003-03-28
KR20020010713A (en) 2002-02-04
IS6201A (en) 2001-12-14
EE200100675A (en) 2003-02-17
AR024577A1 (en) 2002-10-16
HK1045520A1 (en) 2002-11-29
IL146754A0 (en) 2002-07-25
WO2000077000A1 (en) 2000-12-21

Similar Documents

Publication Publication Date Title
BR0014804A (en) Compound, pharmaceutical formulation, use of a compound, prophylaxis method or treatment of an arrhythmia, and, process for the preparation of a compound
BR9813668A (en) Compound, use of the same, process to prepare it, pharmaceutical formulation, and, prophylaxis or treatment of an arrhythmia
BR0016678A (en) Compound, pharmaceutical formulation, use of a compound, method for prophylaxis or treatment of an arrhythmia, and, process for preparing a compound
CY1106178T1 (en) 2'- SUBSTITUTED 1,1'-BIPHENYL-2-CARBOXAMIDES, METHOD FOR THEIR PREPARATION, THEIR USE AS A MEDICINE AS WELL AS PHARMACEUTICAL PREPARATIONS COMPRISING THEM
NO883073D0 (en) 3-DESMETHYL-MEVALONIC ACID DERIVATIVES, THE PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS INTERMEDIATE PRODUCTS.
BR9911482A (en) Compound, pharmaceutical composition, use of the compound, and, processes for the treatment or prophylaxis of inflammatory diseases, and for the preparation of a compound
AR031430A1 (en) ORIS BISARILO COMPOUNDS, META-SUBSTITUTES, PROCEDURES FOR THEIR PREPARATION, ITS USE AS A MEDICINAL PRODUCT AS ALSO THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
BRPI0713457A2 (en) compound, use thereof, pharmaceutical composition, method of treating arrhythmias, agent for treating arrhythmias, and process for preparing a compound
BR9911488A (en) Compound, use of it, pharmaceutical composition, and processes for the treatment or prophylaxis of inflammatory diseases, and for the preparation of a compound
BR9907270A (en) Compound, pharmaceutical composition, use of a compound, and, processes for the treatment or prophylaxis of inflammatory diseases, for example, asthma or copd, and for the preparation of a compound
BR0206791A (en) Compound, pharmaceutical formulation, use of a compound, method of prophylaxis or treatment of an arrhythmia, and process for the preparation of a compound
BR0014695A (en) 5- (2-substituted-5-heterocyclylsulfonylpyrid-3-yl) -dihi dropirazolo [4,3-d] pyrimidin-7-ones as phosphodiesterase inhibitors
BRPI0312464B8 (en) tyrosine kinase inhibitor compounds, pharmaceutical compositions comprising them, processes for manufacturing and uses thereof
BRPI0512012A (en) compound or a pharmaceutically acceptable derivative thereof, pharmaceutical formulation, use of a compound, method of prophylaxis or treatment of an arrhythmia, and process for the preparation of a compound
YU88801A (en) Indanyl-substituted benzole carbonamide, mathod for the production of the same, use thereof as a medicament and pharmaaceutical preparations containing same
WO1998056761A3 (en) Benzimidazole derivatives
BR0309546A (en) A compound, a pharmaceutical composition comprising the same, a process for its preparation and use and a method for the prophylactic or therapeutic treatment of type II diabetes.
BR0108694A (en) Malnic acid derivatives, process for preparing them, use of them as an inhibitor of factor xa activity and pharmaceutical compositions containing the same
BR9810177A (en) Compound, pharmaceutical formulation, use of a compound, and, processes for treating a condition where thrombin inhibition is required and for preparing compounds
BR9100938A (en) COMPOSITION THAT UNDERSTANDS AN ELASTASE INHIBITOR, BENZISOTIAZOLINONE 1-DIOXIDE DERIVATIVES AND COSMETIC TREATMENT PROCESS
RU95111308A (en) Derivatives of 2-amino-4-phenyl-4-oxobutyric acid, methods of synthesis, pharmaceutical composition
BR9806146A (en) Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing the same
BR9803968A (en) Biphenylsulfonylcyanamides, process for their preparation and use as a medicine.
BRPI0512013A (en) compound, pharmaceutical formulation, use of a compound, method for prophylaxis or treatment of an arrhythmia, and process for preparing a compound
MX9300708A (en) LIPOSOMATIC COMPOSITIONS TOPICS INCLUDING ITRACONAZOLE AND PROCEDURE FOR ITS PREPARATION.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.