BG106524A - Piperidine quinolyl propyl derivatives and their use as antibacterial means - Google Patents

Piperidine quinolyl propyl derivatives and their use as antibacterial means

Info

Publication number
BG106524A
BG106524A BG106524A BG10652402A BG106524A BG 106524 A BG106524 A BG 106524A BG 106524 A BG106524 A BG 106524A BG 10652402 A BG10652402 A BG 10652402A BG 106524 A BG106524 A BG 106524A
Authority
BG
Bulgaria
Prior art keywords
piperidine
quinolyl propyl
antibacterial means
propyl derivatives
hydrogen
Prior art date
Application number
BG106524A
Other languages
Bulgarian (bg)
Inventor
Jean-Luc Malleron
Michel Tabart
Jean-Christophe Carry
Michel Evers
Ahmad Youssef El
Serge Mignani
Fabrice Viviani
Michel Cheve
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of BG106524A publication Critical patent/BG106524A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The synthesized compounds are used as active substances for producing means for the treatment of primary bacterial infections. The quinolyl propyl piperidine derivatives have the general formula wherein R1 is hydrogen or halogen atom or hydroxy radical, R'1 is hydrogen atoms or may also mean halogen when R1 is also a halogen atom, Ro is a hydrogen atom, and the meanings of R2, R3 and R4 are given in the description. 11 claims
BG106524A 1999-09-17 2002-03-15 Piperidine quinolyl propyl derivatives and their use as antibacterial means BG106524A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (en) 1999-09-17 1999-09-17 DERIVATIVES OF QUINOLYL PROPYL PIPERIDINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
PCT/FR2000/002541 WO2001025227A2 (en) 1999-09-17 2000-09-14 Quinolyl propyl piperidine derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
BG106524A true BG106524A (en) 2003-01-31

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106524A BG106524A (en) 1999-09-17 2002-03-15 Piperidine quinolyl propyl derivatives and their use as antibacterial means

Country Status (30)

Country Link
EP (2) EP1484328B1 (en)
JP (1) JP2004527448A (en)
KR (1) KR20020038757A (en)
CN (1) CN1374959A (en)
AP (1) AP2002002459A0 (en)
AT (1) ATE284399T1 (en)
AU (1) AU7429500A (en)
BG (1) BG106524A (en)
BR (1) BR0014060A (en)
CA (1) CA2383836A1 (en)
CZ (1) CZ2002940A3 (en)
DE (2) DE60016611T2 (en)
DZ (1) DZ3195A1 (en)
EA (1) EA005183B1 (en)
EE (1) EE200200138A (en)
FR (1) FR2798656B1 (en)
GE (1) GEP20043223B (en)
HR (1) HRP20020214A2 (en)
HU (1) HUP0204283A3 (en)
IL (1) IL148720A0 (en)
MA (1) MA26820A1 (en)
MX (1) MXPA02001979A (en)
NO (1) NO20021253L (en)
OA (1) OA12022A (en)
PL (1) PL354809A1 (en)
SK (1) SK3632002A3 (en)
TN (1) TNSN00184A1 (en)
WO (1) WO2001025227A2 (en)
YU (1) YU19002A (en)
ZA (1) ZA200202073B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
PL366335A1 (en) 2000-07-26 2005-01-24 Smithkline Beecham P.L.C. Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AU2003239302A1 (en) 2002-01-29 2003-09-02 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200406410A (en) 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND
FR2842807A1 (en) * 2002-07-23 2004-01-30 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, PROCESS AND PREPARATION INTERMEDIATES AND COMPOSITIONS COMPRISING THE SAME
FR2844270B1 (en) 2002-09-11 2006-05-19 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, THEIR PROCESS AND PREPARATION INTERMEDIATES AND THE COMPOSITIONS CONTAINING THEM
FR2844268B1 (en) 2002-09-11 2004-10-22 Aventis Pharma Sa QUINOLYL PROPYL PIPERIDINE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION, AND COMPOSITIONS CONTAINING THEM
CA2500320A1 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Novel compounds with antibacterial activity
WO2004041210A2 (en) 2002-11-05 2004-05-21 Smithkline Beecham Corporation Antibacterial agents
DE60331849D1 (en) 2002-11-05 2010-05-06 Glaxosmithkline Llc ANTIBACTERIAL ACTIVE SUBSTANCES
EP1567520B1 (en) 2002-12-04 2008-10-15 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
ATE466857T1 (en) * 2004-10-05 2010-05-15 Actelion Pharmaceuticals Ltd NEW PIPERIDINE ANTIBIOTICS
EP1799674B1 (en) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. New piperidine antibiotics
JP2008528586A (en) 2005-01-25 2008-07-31 グラクソ グループ リミテッド Antibacterial agent
US7605169B2 (en) 2005-01-25 2009-10-20 Glaxo Group Limited Antibacterial agents
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
EP1845995A4 (en) 2005-01-25 2010-03-03 Glaxo Group Ltd Antibacterial agents
JP2009524643A (en) 2006-01-26 2009-07-02 アクテリオン ファーマシューティカルズ リミテッド Tetrahydropyran antibiotics
JP2009532423A (en) 2006-04-06 2009-09-10 グラクソ グループ リミテッド Pyrrolo-quinoxalinone derivatives as antibacterial agents
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
AU2008249745B2 (en) * 2007-05-09 2012-01-12 Pfizer Inc. Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (en) 2009-01-15 2016-02-29 Glaxo Group Limited Naphthyridine-2 (1H) -one compounds useful as antibacterial agents
JP6483666B2 (en) * 2013-10-14 2019-03-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Selectively substituted quinoline compounds
EP3182973B1 (en) 2014-08-22 2019-09-18 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
TW201722965A (en) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 Compounds for use in antibacterial applications
EP3889145B1 (en) 2015-12-17 2024-02-21 Merck Patent GmbH 8-cyano-5-piperidino-quinolines as tlr7/8 antagonists and their uses for treating immune disorders
MX2019001096A (en) 2016-08-08 2019-07-04 Merck Patent Gmbh Tlr7/8 antagonists and uses thereof.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2717899A (en) * 1998-01-26 1999-08-09 Smithkline Beecham Plc Quinoline derivatives as antibacterials
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors

Also Published As

Publication number Publication date
OA12022A (en) 2006-04-19
MXPA02001979A (en) 2002-08-20
FR2798656B1 (en) 2004-12-17
EP1484328A1 (en) 2004-12-08
HRP20020214A2 (en) 2005-04-30
EE200200138A (en) 2003-06-16
DZ3195A1 (en) 2001-04-12
IL148720A0 (en) 2002-09-12
DE60016611D1 (en) 2005-01-13
EP1218370A2 (en) 2002-07-03
DE60016611T2 (en) 2005-12-22
ATE284399T1 (en) 2004-12-15
GEP20043223B (en) 2004-04-26
CN1374959A (en) 2002-10-16
JP2004527448A (en) 2004-09-09
WO2001025227A3 (en) 2001-11-22
WO2001025227A2 (en) 2001-04-12
NO20021253L (en) 2002-04-24
EA005183B1 (en) 2004-12-30
YU19002A (en) 2005-06-10
SK3632002A3 (en) 2003-04-01
EA200200374A1 (en) 2002-10-31
BR0014060A (en) 2002-05-21
EP1218370B1 (en) 2004-12-08
HUP0204283A3 (en) 2004-07-28
DE60034713T2 (en) 2008-01-17
ZA200202073B (en) 2003-08-27
DE60034713D1 (en) 2007-06-14
KR20020038757A (en) 2002-05-23
FR2798656A1 (en) 2001-03-23
AU7429500A (en) 2001-05-10
PL354809A1 (en) 2004-02-23
AP2002002459A0 (en) 2002-06-30
MA26820A1 (en) 2004-12-20
CZ2002940A3 (en) 2002-07-17
TNSN00184A1 (en) 2005-11-10
HUP0204283A2 (en) 2003-04-28
EP1484328B1 (en) 2007-05-02
CA2383836A1 (en) 2001-04-12
NO20021253D0 (en) 2002-03-13

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