BG106524A - Хинолил пропил пиперидинови производни и използването им като антибактериални средства - Google Patents

Хинолил пропил пиперидинови производни и използването им като антибактериални средства

Info

Publication number
BG106524A
BG106524A BG106524A BG10652402A BG106524A BG 106524 A BG106524 A BG 106524A BG 106524 A BG106524 A BG 106524A BG 10652402 A BG10652402 A BG 10652402A BG 106524 A BG106524 A BG 106524A
Authority
BG
Bulgaria
Prior art keywords
piperidine
quinolyl propyl
antibacterial means
propyl derivatives
hydrogen
Prior art date
Application number
BG106524A
Other languages
English (en)
Inventor
Jean-Luc Malleron
Michel Tabart
Jean-Christophe Carry
Michel Evers
Ahmad Youssef El
Serge Mignani
Fabrice Viviani
Michel Cheve
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of BG106524A publication Critical patent/BG106524A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Синтезираните съединения се използват като активни субстанции за получаване на средства за лечение на първични бактериални инфекции. Хинолил пропил пиперидиновите производни имат обща формула@@в която R1 е водороден или халогенен атом или хидроксирадикал, R'1 е водороден атом или може да означава халоген, когато R1 също е халогенен атом, Ro е водороден атом, а значенията на R2, R3 и R4 са посочени в описанието.
BG106524A 1999-09-17 2002-03-15 Хинолил пропил пиперидинови производни и използването им като антибактериални средства BG106524A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9911679A FR2798656B1 (fr) 1999-09-17 1999-09-17 Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2000/002541 WO2001025227A2 (fr) 1999-09-17 2000-09-14 Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens

Publications (1)

Publication Number Publication Date
BG106524A true BG106524A (bg) 2003-01-31

Family

ID=9549990

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106524A BG106524A (bg) 1999-09-17 2002-03-15 Хинолил пропил пиперидинови производни и използването им като антибактериални средства

Country Status (30)

Country Link
EP (2) EP1484328B1 (bg)
JP (1) JP2004527448A (bg)
KR (1) KR20020038757A (bg)
CN (1) CN1374959A (bg)
AP (1) AP2002002459A0 (bg)
AT (1) ATE284399T1 (bg)
AU (1) AU7429500A (bg)
BG (1) BG106524A (bg)
BR (1) BR0014060A (bg)
CA (1) CA2383836A1 (bg)
CZ (1) CZ2002940A3 (bg)
DE (2) DE60016611T2 (bg)
DZ (1) DZ3195A1 (bg)
EA (1) EA005183B1 (bg)
EE (1) EE200200138A (bg)
FR (1) FR2798656B1 (bg)
GE (1) GEP20043223B (bg)
HR (1) HRP20020214A2 (bg)
HU (1) HUP0204283A3 (bg)
IL (1) IL148720A0 (bg)
MA (1) MA26820A1 (bg)
MX (1) MXPA02001979A (bg)
NO (1) NO20021253L (bg)
OA (1) OA12022A (bg)
PL (1) PL354809A1 (bg)
SK (1) SK3632002A3 (bg)
TN (1) TNSN00184A1 (bg)
WO (1) WO2001025227A2 (bg)
YU (1) YU19002A (bg)
ZA (1) ZA200202073B (bg)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822440D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
PL366335A1 (en) 2000-07-26 2005-01-24 Smithkline Beecham P.L.C. Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
JP4508650B2 (ja) 2002-01-29 2010-07-21 グラクソ グループ リミテッド アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物
EP2181996A1 (en) 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidine derivatives
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
FR2842807A1 (fr) * 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
WO2004035569A2 (de) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
DE60331849D1 (de) 2002-11-05 2010-05-06 Glaxosmithkline Llc Antibakterielle wirkstoffe
EP1560488B1 (en) 2002-11-05 2010-09-01 Glaxo Group Limited Antibacterial agents
EP1567520B1 (en) 2002-12-04 2008-10-15 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
EP1799674B1 (en) * 2004-10-05 2010-05-05 Actelion Pharmaceuticals Ltd. New piperidine antibiotics
WO2006038172A1 (en) * 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
JP2008528587A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
US7592334B2 (en) 2005-01-25 2009-09-22 Glaxo Group Limited Antibacterial agents
WO2006081178A2 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1981881B1 (en) 2006-01-26 2011-12-07 Actelion Pharmaceuticals Ltd. Tetrahydropyrane antibiotics
DE602007009205D1 (de) 2006-04-06 2010-10-28 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
MX2009012117A (es) * 2007-05-09 2009-11-23 Pfizer Composiciones y derivados heterociclicos sustituidos y su uso farmaceutico como antibacterianos.
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
JP2012505866A (ja) 2008-10-17 2012-03-08 グラクソ グループ リミテッド 抗菌剤として使用される三環式窒素化合物
WO2010081874A1 (en) 2009-01-15 2010-07-22 Glaxo Group Limited Naphthyridin-2 (1 h)-one compounds useful as antibacterials
KR102365952B1 (ko) * 2013-10-14 2022-02-22 에자이 알앤드디 매니지먼트 가부시키가이샤 선택적으로 치환된 퀴놀린 화합물
BR112017003705B1 (pt) 2014-08-22 2022-07-12 Glaxosmithkline Intellectual Property Development Limited Compostos contendo nitrogênio tricíclicos para o tratamento de infecção por neisseria gonorrhoea
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
SI3889145T1 (sl) 2015-12-17 2024-05-31 Merck Patent Gmbh 8-ciano-5-piperidino-kinolini kot antagonisti tlr7/8 in njihove uporabe za zdravljenje imunskih motenj
DK3497094T3 (da) 2016-08-08 2023-05-15 Merck Patent Gmbh Tlr7/8-antagonister og anvendelser deraf

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1051413B1 (en) * 1998-01-26 2003-06-04 SmithKline Beecham plc Quinoline derivatives as antibacterials
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors

Also Published As

Publication number Publication date
KR20020038757A (ko) 2002-05-23
HRP20020214A2 (en) 2005-04-30
EP1218370A2 (fr) 2002-07-03
MXPA02001979A (es) 2002-08-20
YU19002A (sh) 2005-06-10
EP1484328A1 (fr) 2004-12-08
WO2001025227A2 (fr) 2001-04-12
DE60034713D1 (de) 2007-06-14
CZ2002940A3 (cs) 2002-07-17
IL148720A0 (en) 2002-09-12
FR2798656A1 (fr) 2001-03-23
HUP0204283A3 (en) 2004-07-28
EP1218370B1 (fr) 2004-12-08
EA200200374A1 (ru) 2002-10-31
WO2001025227A3 (fr) 2001-11-22
TNSN00184A1 (fr) 2005-11-10
CA2383836A1 (fr) 2001-04-12
DE60034713T2 (de) 2008-01-17
EP1484328B1 (fr) 2007-05-02
GEP20043223B (en) 2004-04-26
BR0014060A (pt) 2002-05-21
MA26820A1 (fr) 2004-12-20
EE200200138A (et) 2003-06-16
DZ3195A1 (fr) 2001-04-12
JP2004527448A (ja) 2004-09-09
AU7429500A (en) 2001-05-10
DE60016611T2 (de) 2005-12-22
NO20021253L (no) 2002-04-24
HUP0204283A2 (hu) 2003-04-28
ZA200202073B (en) 2003-08-27
AP2002002459A0 (en) 2002-06-30
SK3632002A3 (en) 2003-04-01
CN1374959A (zh) 2002-10-16
FR2798656B1 (fr) 2004-12-17
DE60016611D1 (de) 2005-01-13
ATE284399T1 (de) 2004-12-15
PL354809A1 (en) 2004-02-23
EA005183B1 (ru) 2004-12-30
NO20021253D0 (no) 2002-03-13
OA12022A (fr) 2006-04-19

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