BG103947A - Производни на 9-оксимеритромицин - Google Patents

Производни на 9-оксимеритромицин

Info

Publication number
BG103947A
BG103947A BG103947A BG10394799A BG103947A BG 103947 A BG103947 A BG 103947A BG 103947 A BG103947 A BG 103947A BG 10394799 A BG10394799 A BG 10394799A BG 103947 A BG103947 A BG 103947A
Authority
BG
Bulgaria
Prior art keywords
oxymerythromycin
derivatives
compounds
methods
relates
Prior art date
Application number
BG103947A
Other languages
English (en)
Inventor
Yong- Jin WU
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG103947A publication Critical patent/BG103947A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретението се отнася до съединения или техни фармацевтично приемливи соли с формула@@в която R1,R2, R6 и Х имат значенията, посочени в описанието. Изобретението се отнася и до фармацевтични състави, съдържащи съединенията, до методи за използването им за лечение на бактериални протозойни инфекции, както и до методи за тяхното получаване.
BG103947A 1997-06-11 1999-12-03 Производни на 9-оксимеритромицин BG103947A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11
PCT/IB1998/000741 WO1998056800A1 (en) 1997-06-11 1998-05-15 9-oxime erythromycin derivatives

Publications (1)

Publication Number Publication Date
BG103947A true BG103947A (bg) 2000-07-31

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103947A BG103947A (bg) 1997-06-11 1999-12-03 Производни на 9-оксимеритромицин

Country Status (31)

Country Link
EP (1) EP0988308A1 (bg)
JP (1) JP2000513026A (bg)
KR (1) KR20010013660A (bg)
CN (1) CN1259135A (bg)
AP (1) AP9801253A0 (bg)
AR (1) AR012244A1 (bg)
AU (1) AU7226798A (bg)
BG (1) BG103947A (bg)
BR (1) BR9810021A (bg)
CA (1) CA2293335A1 (bg)
CO (1) CO4940506A1 (bg)
CZ (1) CZ9904388A3 (bg)
EA (1) EA199901016A1 (bg)
GT (1) GT199800074A (bg)
HN (1) HN1998000073A (bg)
HR (1) HRP980316A2 (bg)
HU (1) HUP0002252A3 (bg)
ID (1) ID24529A (bg)
IL (1) IL132767A0 (bg)
IS (1) IS5251A (bg)
MA (1) MA26505A1 (bg)
NO (1) NO996108L (bg)
OA (1) OA11225A (bg)
PA (1) PA8451801A1 (bg)
PE (1) PE79899A1 (bg)
PL (1) PL337606A1 (bg)
TN (1) TNSN98083A1 (bg)
TR (1) TR199902995T2 (bg)
TW (1) TW448174B (bg)
WO (1) WO1998056800A1 (bg)
ZA (1) ZA985018B (bg)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
CN1241931C (zh) * 1999-04-16 2006-02-15 高山生物科学股份有限公司 大环内酯抗感染药物
IL145739A0 (en) 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
EP1181300B1 (en) * 1999-06-07 2003-09-17 Abbott Laboratories 6-o-carbamate ketolide derivatives
ID27331A (id) * 1999-09-29 2001-03-29 Pfizer Prod Inc Pembuatan antibiotik-antibiotik ketolida karbamat
EP1114826A3 (en) * 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
EP1439186A3 (en) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermediates for novel antibacterial and prokinetic macrolides
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) * 2002-04-25 2003-11-06 Abbott Laboratories 9-oxime macrolide antibacterials
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
ES2552682T3 (es) * 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
CN105616437A (zh) 2008-10-24 2016-06-01 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
CN102146085B (zh) * 2010-02-09 2014-03-26 北京理工大学 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
CA2793884C (en) 2010-03-22 2019-09-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
AU2013239696C1 (en) 2012-03-27 2018-11-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
PL337606A1 (en) 2000-08-28
WO1998056800A1 (en) 1998-12-17
EP0988308A1 (en) 2000-03-29
GT199800074A (es) 1999-11-27
MA26505A1 (fr) 2004-12-20
TNSN98083A1 (fr) 2005-03-15
PA8451801A1 (es) 2000-05-24
IL132767A0 (en) 2001-03-19
ID24529A (id) 2000-07-20
KR20010013660A (ko) 2001-02-26
ZA985018B (en) 1999-12-10
NO996108D0 (no) 1999-12-10
HN1998000073A (es) 1999-01-08
AU7226798A (en) 1998-12-30
CZ9904388A3 (cs) 2002-10-16
CO4940506A1 (es) 2000-07-24
OA11225A (en) 2003-07-17
BR9810021A (pt) 2000-09-19
NO996108L (no) 2000-02-10
IS5251A (is) 1999-11-16
HUP0002252A2 (hu) 2000-12-28
AR012244A1 (es) 2000-09-27
JP2000513026A (ja) 2000-10-03
PE79899A1 (es) 1999-08-25
CN1259135A (zh) 2000-07-05
CA2293335A1 (en) 1998-12-17
TW448174B (en) 2001-08-01
HUP0002252A3 (en) 2002-01-28
EA199901016A1 (ru) 2000-06-26
HRP980316A2 (en) 1999-04-30
TR199902995T2 (xx) 2000-02-21
AP9801253A0 (en) 1999-12-04

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