YU46302A - Supstituisani piroli - Google Patents
Supstituisani piroliInfo
- Publication number
- YU46302A YU46302A YU46302A YUP46302A YU46302A YU 46302 A YU46302 A YU 46302A YU 46302 A YU46302 A YU 46302A YU P46302 A YUP46302 A YU P46302A YU 46302 A YU46302 A YU 46302A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituted pyrroles
- disclosed
- compounds
- useful
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Opisani su supstituisani piroli formule (I), naznačen time, što R1, R2, R1' i R2" imaju značenje kao što je opisano u zathevima i opisu pronalaska. Ova jedinjenja i njihove farmaceutski prihvatljive soli mogu se primeniti u terapiji i/ii kontroli poremećaja uslovljenih proliferacijom ćelija, i konkretno kancera. Takodje su opisane farmaceutske smeše koje sadrže prethodno navedena jedinjenja.[Disclosed are substituted pyrroles having formula (I), wherein R1, R2, R1' and R2' are as defined in the claims and in the description. These compounds and their pharmaceutically acceptable salts are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17155799P | 1999-12-22 | 1999-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU46302A true YU46302A (sh) | 2005-06-10 |
Family
ID=22624198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU46302A YU46302A (sh) | 1999-12-22 | 2000-12-21 | Supstituisani piroli |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6281356B1 (sh) |
| EP (1) | EP1242409A2 (sh) |
| JP (1) | JP2003518112A (sh) |
| KR (1) | KR100508741B1 (sh) |
| CN (1) | CN1193027C (sh) |
| AR (1) | AR027035A1 (sh) |
| AU (1) | AU782920B2 (sh) |
| BR (1) | BR0016516A (sh) |
| CA (1) | CA2394852A1 (sh) |
| CO (1) | CO5090902A1 (sh) |
| CZ (1) | CZ20022492A3 (sh) |
| HK (1) | HK1054382A1 (sh) |
| HR (1) | HRP20020536A2 (sh) |
| HU (1) | HUP0204572A3 (sh) |
| IL (1) | IL150200A0 (sh) |
| JO (1) | JO2199B1 (sh) |
| MA (1) | MA26860A1 (sh) |
| MX (1) | MXPA02006162A (sh) |
| MY (1) | MY133682A (sh) |
| NO (1) | NO20022927L (sh) |
| NZ (1) | NZ519359A (sh) |
| PE (1) | PE20011098A1 (sh) |
| PL (1) | PL357603A1 (sh) |
| RU (1) | RU2261862C2 (sh) |
| UY (1) | UY26498A1 (sh) |
| WO (1) | WO2001046178A2 (sh) |
| YU (1) | YU46302A (sh) |
| ZA (1) | ZA200204313B (sh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| TWI324064B (en) * | 2002-04-03 | 2010-05-01 | Novartis Ag | Indolylmaleimide derivatives |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| MX2015012456A (es) | 2013-03-15 | 2016-02-03 | Plexxikon Inc | Compuestos heterociclicos y usos de los mismos. |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| PT3272745T (pt) | 2016-07-21 | 2019-09-27 | Inst Farmakologii Polskiej Akademii Nauk | Derivados de indol substituídos com imidazolilo que se ligam ao recetor de serotonina 5-ht7 e composições farmacêuticas dos mesmos |
| EP3694855A1 (en) | 2017-10-13 | 2020-08-19 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK278989B6 (sk) | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| JPH07504673A (ja) | 1992-03-20 | 1995-05-25 | ザ・ウエルカム・ファウンデーション・リミテッド | 抗ウイルス活性を有するインドール誘導体 |
| ES2125976T3 (es) * | 1992-03-20 | 1999-03-16 | Wellcome Found | Otros derivados de indol con accion antiviral. |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| PE91698A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| TR200002580T2 (tr) * | 1998-03-17 | 2000-11-21 | F.Hoffmann-La Roche Ag | Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler |
-
2000
- 2000-12-15 US US09/737,685 patent/US6281356B1/en not_active Expired - Fee Related
- 2000-12-19 JO JO2000203A patent/JO2199B1/en active
- 2000-12-20 AR ARP000106792A patent/AR027035A1/es not_active Application Discontinuation
- 2000-12-20 MY MYPI20006018A patent/MY133682A/en unknown
- 2000-12-20 CO CO00096628A patent/CO5090902A1/es unknown
- 2000-12-21 JP JP2001547088A patent/JP2003518112A/ja active Pending
- 2000-12-21 PE PE2000001386A patent/PE20011098A1/es not_active Application Discontinuation
- 2000-12-21 HU HU0204572A patent/HUP0204572A3/hu unknown
- 2000-12-21 MX MXPA02006162A patent/MXPA02006162A/es not_active Application Discontinuation
- 2000-12-21 KR KR10-2002-7008019A patent/KR100508741B1/ko not_active IP Right Cessation
- 2000-12-21 AU AU37267/01A patent/AU782920B2/en not_active Ceased
- 2000-12-21 IL IL15020000A patent/IL150200A0/xx unknown
- 2000-12-21 BR BR0016516-6A patent/BR0016516A/pt not_active IP Right Cessation
- 2000-12-21 CN CNB008173885A patent/CN1193027C/zh not_active Expired - Fee Related
- 2000-12-21 NZ NZ519359A patent/NZ519359A/en unknown
- 2000-12-21 YU YU46302A patent/YU46302A/sh unknown
- 2000-12-21 WO PCT/EP2000/013026 patent/WO2001046178A2/en not_active Application Discontinuation
- 2000-12-21 UY UY26498A patent/UY26498A1/es not_active Application Discontinuation
- 2000-12-21 PL PL00357603A patent/PL357603A1/xx not_active Application Discontinuation
- 2000-12-21 CA CA002394852A patent/CA2394852A1/en not_active Abandoned
- 2000-12-21 RU RU2002119557/04A patent/RU2261862C2/ru not_active IP Right Cessation
- 2000-12-21 CZ CZ20022492A patent/CZ20022492A3/cs unknown
- 2000-12-21 EP EP00991984A patent/EP1242409A2/en not_active Withdrawn
-
2002
- 2002-05-29 ZA ZA200204313A patent/ZA200204313B/en unknown
- 2002-06-18 NO NO20022927A patent/NO20022927L/no not_active Application Discontinuation
- 2002-06-20 HR HR20020536A patent/HRP20020536A2/hr not_active Application Discontinuation
- 2002-06-21 MA MA26707A patent/MA26860A1/fr unknown
-
2003
- 2003-09-15 HK HK03106619A patent/HK1054382A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL150200A0 (en) | 2002-12-01 |
| CN1193027C (zh) | 2005-03-16 |
| RU2261862C2 (ru) | 2005-10-10 |
| WO2001046178A3 (en) | 2001-12-06 |
| NO20022927D0 (no) | 2002-06-18 |
| HK1054382A1 (en) | 2003-11-28 |
| WO2001046178A2 (en) | 2001-06-28 |
| CO5090902A1 (es) | 2001-10-30 |
| US6281356B1 (en) | 2001-08-28 |
| CA2394852A1 (en) | 2001-06-28 |
| CN1411457A (zh) | 2003-04-16 |
| MXPA02006162A (es) | 2002-12-05 |
| CZ20022492A3 (cs) | 2003-02-12 |
| BR0016516A (pt) | 2002-09-17 |
| MY133682A (en) | 2007-11-30 |
| AR027035A1 (es) | 2003-03-12 |
| EP1242409A2 (en) | 2002-09-25 |
| AU3726701A (en) | 2001-07-03 |
| HUP0204572A2 (en) | 2003-05-28 |
| NO20022927L (no) | 2002-06-18 |
| KR20020062365A (ko) | 2002-07-25 |
| ZA200204313B (en) | 2003-08-29 |
| HUP0204572A3 (en) | 2004-07-28 |
| JO2199B1 (en) | 2003-12-23 |
| JP2003518112A (ja) | 2003-06-03 |
| RU2002119557A (ru) | 2004-01-10 |
| UY26498A1 (es) | 2001-06-29 |
| MA26860A1 (fr) | 2004-12-20 |
| PL357603A1 (en) | 2004-07-26 |
| PE20011098A1 (es) | 2001-10-26 |
| KR100508741B1 (ko) | 2005-08-17 |
| HRP20020536A2 (en) | 2004-08-31 |
| AU782920B2 (en) | 2005-09-08 |
| NZ519359A (en) | 2004-04-30 |
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