BR0016516A - Pirróis substituìdos - Google Patents

Pirróis substituìdos

Info

Publication number
BR0016516A
BR0016516A BR0016516-6A BR0016516A BR0016516A BR 0016516 A BR0016516 A BR 0016516A BR 0016516 A BR0016516 A BR 0016516A BR 0016516 A BR0016516 A BR 0016516A
Authority
BR
Brazil
Prior art keywords
replaced
pyrroles
disclosed
compounds
pirróis
Prior art date
Application number
BR0016516-6A
Other languages
English (en)
Inventor
Nader Fotouhi
Norman Kong
Allen John Lovey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0016516A publication Critical patent/BR0016516A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PIRRóIS SUBSTITUìDOS". Divulgado são pirróis substituídos tendo a fórmula (I), em que R^ 1^, R^ 2^, R^ 1'^ e R^ 2'^ são como definidos nas reivindicações e na descrição. Estes compostos e seus sais farmaceuticamente aceitáveis são úteis no tratamento e/ou controle de distúrbios proliferativos celulares, em particular câncer. Também divulgado são composições farmacêuticas contendo os compostos anteriores.
BR0016516-6A 1999-12-22 2000-12-21 Pirróis substituìdos BR0016516A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17155799P 1999-12-22 1999-12-22
PCT/EP2000/013026 WO2001046178A2 (en) 1999-12-22 2000-12-21 Substituierte bisindolymaleimide

Publications (1)

Publication Number Publication Date
BR0016516A true BR0016516A (pt) 2002-09-17

Family

ID=22624198

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016516-6A BR0016516A (pt) 1999-12-22 2000-12-21 Pirróis substituìdos

Country Status (28)

Country Link
US (1) US6281356B1 (pt)
EP (1) EP1242409A2 (pt)
JP (1) JP2003518112A (pt)
KR (1) KR100508741B1 (pt)
CN (1) CN1193027C (pt)
AR (1) AR027035A1 (pt)
AU (1) AU782920B2 (pt)
BR (1) BR0016516A (pt)
CA (1) CA2394852A1 (pt)
CO (1) CO5090902A1 (pt)
CZ (1) CZ20022492A3 (pt)
HK (1) HK1054382A1 (pt)
HR (1) HRP20020536A2 (pt)
HU (1) HUP0204572A3 (pt)
IL (1) IL150200A0 (pt)
JO (1) JO2199B1 (pt)
MA (1) MA26860A1 (pt)
MX (1) MXPA02006162A (pt)
MY (1) MY133682A (pt)
NO (1) NO20022927L (pt)
NZ (1) NZ519359A (pt)
PE (1) PE20011098A1 (pt)
PL (1) PL357603A1 (pt)
RU (1) RU2261862C2 (pt)
UY (1) UY26498A1 (pt)
WO (1) WO2001046178A2 (pt)
YU (1) YU46302A (pt)
ZA (1) ZA200204313B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
TW200918046A (en) 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
TWI634111B (zh) 2013-03-15 2018-09-01 普雷辛肯公司 雜環化合物及其用途
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
HUE045355T2 (hu) 2016-07-21 2019-12-30 Inst Farmakologii Polskiej Akademii Nauk Az 5-HT7 szerotoninreceptort kötõ imidazolil-szubsztituált indolszármazékok és gyógyszerészeti készítményeik
JP2020536917A (ja) 2017-10-13 2020-12-17 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼを調節するための化合物の固体形態

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5547976A (en) * 1992-03-20 1996-08-20 Burroughs Wellcome Co. Further indole derivatives with antiviral activity
EP0630241A1 (en) 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
PE91498A1 (es) 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
RS49965B (sr) * 1998-03-17 2008-09-29 F.Hoffmann-La Roche Ag., Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije

Also Published As

Publication number Publication date
AU782920B2 (en) 2005-09-08
NO20022927D0 (no) 2002-06-18
IL150200A0 (en) 2002-12-01
JP2003518112A (ja) 2003-06-03
YU46302A (sh) 2005-06-10
RU2002119557A (ru) 2004-01-10
EP1242409A2 (en) 2002-09-25
CA2394852A1 (en) 2001-06-28
NZ519359A (en) 2004-04-30
UY26498A1 (es) 2001-06-29
KR100508741B1 (ko) 2005-08-17
CO5090902A1 (es) 2001-10-30
AU3726701A (en) 2001-07-03
RU2261862C2 (ru) 2005-10-10
WO2001046178A2 (en) 2001-06-28
WO2001046178A3 (en) 2001-12-06
HUP0204572A2 (en) 2003-05-28
AR027035A1 (es) 2003-03-12
HRP20020536A2 (en) 2004-08-31
US6281356B1 (en) 2001-08-28
HUP0204572A3 (en) 2004-07-28
PL357603A1 (en) 2004-07-26
CN1411457A (zh) 2003-04-16
MXPA02006162A (es) 2002-12-05
KR20020062365A (ko) 2002-07-25
ZA200204313B (en) 2003-08-29
MA26860A1 (fr) 2004-12-20
MY133682A (en) 2007-11-30
CZ20022492A3 (cs) 2003-02-12
HK1054382A1 (en) 2003-11-28
CN1193027C (zh) 2005-03-16
NO20022927L (no) 2002-06-18
JO2199B1 (en) 2003-12-23
PE20011098A1 (es) 2001-10-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.