PE20011098A1 - Derivados sustituidos de 3,4-bis-(1h-indol-3-il)-pirrol-2,5-diona como agentes antiproliferativos - Google Patents
Derivados sustituidos de 3,4-bis-(1h-indol-3-il)-pirrol-2,5-diona como agentes antiproliferativosInfo
- Publication number
- PE20011098A1 PE20011098A1 PE2000001386A PE0013862000A PE20011098A1 PE 20011098 A1 PE20011098 A1 PE 20011098A1 PE 2000001386 A PE2000001386 A PE 2000001386A PE 0013862000 A PE0013862000 A PE 0013862000A PE 20011098 A1 PE20011098 A1 PE 20011098A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- diona
- methyl
- pirrol
- bis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE REFIERE A PIRROLES SUSTITUIDOS DE FORMULA I DONDE R1 Y R1' SON H, ALQUILO, ALQUENILO, ALQUINILO; R2 ES H, NITRO, CIANO, HALOGENO, ALQUILO, ALQUENILO, ALQUINILO, ALCOXILO; R2' ES HETEROARILO, HETEROCICLO, ETILO SUSTITUIDO CON HETEROARILO, ETOXILO SUSTITUIDO CON HETEROARILO, HETEROCICLO. SON COMPUESTOS PREFERIDOS 3-(1-METIL-1H-INDOL-3-IL)-4-(1-METIL-6-TIOFEN-2-IL-1H-INDOL-3-IL)PIRROL-2,5-DIONA; 3-(6-FURAN-2-IL-1-METIL-1H-INDOL-3-IL)-4-(1-METIL-1H-INDOL-3-IL)PIRROL-2,5-DIONA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS INHIBEN LA DIVISION CELULAR EN FASE G2/M DEL CICLO CELULAR Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS CELULARES CANCER, TUMORES SOLIDOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17155799P | 1999-12-22 | 1999-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011098A1 true PE20011098A1 (es) | 2001-10-26 |
Family
ID=22624198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001386A PE20011098A1 (es) | 1999-12-22 | 2000-12-21 | Derivados sustituidos de 3,4-bis-(1h-indol-3-il)-pirrol-2,5-diona como agentes antiproliferativos |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6281356B1 (es) |
| EP (1) | EP1242409A2 (es) |
| JP (1) | JP2003518112A (es) |
| KR (1) | KR100508741B1 (es) |
| CN (1) | CN1193027C (es) |
| AR (1) | AR027035A1 (es) |
| AU (1) | AU782920B2 (es) |
| BR (1) | BR0016516A (es) |
| CA (1) | CA2394852A1 (es) |
| CO (1) | CO5090902A1 (es) |
| CZ (1) | CZ20022492A3 (es) |
| HK (1) | HK1054382A1 (es) |
| HR (1) | HRP20020536A2 (es) |
| HU (1) | HUP0204572A3 (es) |
| IL (1) | IL150200A0 (es) |
| JO (1) | JO2199B1 (es) |
| MA (1) | MA26860A1 (es) |
| MX (1) | MXPA02006162A (es) |
| MY (1) | MY133682A (es) |
| NO (1) | NO20022927L (es) |
| NZ (1) | NZ519359A (es) |
| PE (1) | PE20011098A1 (es) |
| PL (1) | PL357603A1 (es) |
| RU (1) | RU2261862C2 (es) |
| UY (1) | UY26498A1 (es) |
| WO (1) | WO2001046178A2 (es) |
| YU (1) | YU46302A (es) |
| ZA (1) | ZA200204313B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030139373A1 (en) * | 2001-11-20 | 2003-07-24 | Breimer Lars Holger | Method for cancer therapy |
| TWI324064B (en) | 2002-04-03 | 2010-05-01 | Novartis Ag | Indolylmaleimide derivatives |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| MX2015012456A (es) | 2013-03-15 | 2016-02-03 | Plexxikon Inc | Compuestos heterociclicos y usos de los mismos. |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| PT3272745T (pt) | 2016-07-21 | 2019-09-27 | Inst Farmakologii Polskiej Akademii Nauk | Derivados de indol substituídos com imidazolilo que se ligam ao recetor de serotonina 5-ht7 e composições farmacêuticas dos mesmos |
| EP3694855A1 (en) | 2017-10-13 | 2020-08-19 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK278989B6 (sk) | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| AU3761393A (en) | 1992-03-20 | 1993-10-21 | Wellcome Foundation Limited, The | Indole derivatives with antiviral activity |
| WO1993018766A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Further indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| PE91698A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| PE91498A1 (es) | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
| PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| EP1064279B1 (en) * | 1998-03-17 | 2003-06-25 | F.Hoffmann-La Roche Ag | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
-
2000
- 2000-12-15 US US09/737,685 patent/US6281356B1/en not_active Expired - Fee Related
- 2000-12-19 JO JO2000203A patent/JO2199B1/en active
- 2000-12-20 CO CO00096628A patent/CO5090902A1/es unknown
- 2000-12-20 MY MYPI20006018A patent/MY133682A/en unknown
- 2000-12-20 AR ARP000106792A patent/AR027035A1/es not_active Application Discontinuation
- 2000-12-21 YU YU46302A patent/YU46302A/sh unknown
- 2000-12-21 IL IL15020000A patent/IL150200A0/xx unknown
- 2000-12-21 PE PE2000001386A patent/PE20011098A1/es not_active Application Discontinuation
- 2000-12-21 MX MXPA02006162A patent/MXPA02006162A/es not_active Application Discontinuation
- 2000-12-21 CZ CZ20022492A patent/CZ20022492A3/cs unknown
- 2000-12-21 PL PL00357603A patent/PL357603A1/xx not_active Application Discontinuation
- 2000-12-21 EP EP00991984A patent/EP1242409A2/en not_active Withdrawn
- 2000-12-21 KR KR10-2002-7008019A patent/KR100508741B1/ko not_active IP Right Cessation
- 2000-12-21 UY UY26498A patent/UY26498A1/es not_active Application Discontinuation
- 2000-12-21 CA CA002394852A patent/CA2394852A1/en not_active Abandoned
- 2000-12-21 WO PCT/EP2000/013026 patent/WO2001046178A2/en not_active Application Discontinuation
- 2000-12-21 JP JP2001547088A patent/JP2003518112A/ja active Pending
- 2000-12-21 NZ NZ519359A patent/NZ519359A/en unknown
- 2000-12-21 RU RU2002119557/04A patent/RU2261862C2/ru not_active IP Right Cessation
- 2000-12-21 HU HU0204572A patent/HUP0204572A3/hu unknown
- 2000-12-21 AU AU37267/01A patent/AU782920B2/en not_active Ceased
- 2000-12-21 BR BR0016516-6A patent/BR0016516A/pt not_active IP Right Cessation
- 2000-12-21 CN CNB008173885A patent/CN1193027C/zh not_active Expired - Fee Related
-
2002
- 2002-05-29 ZA ZA200204313A patent/ZA200204313B/en unknown
- 2002-06-18 NO NO20022927A patent/NO20022927L/no not_active Application Discontinuation
- 2002-06-20 HR HR20020536A patent/HRP20020536A2/hr not_active Application Discontinuation
- 2002-06-21 MA MA26707A patent/MA26860A1/fr unknown
-
2003
- 2003-09-15 HK HK03106619A patent/HK1054382A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20022927D0 (no) | 2002-06-18 |
| CA2394852A1 (en) | 2001-06-28 |
| MXPA02006162A (es) | 2002-12-05 |
| NO20022927L (no) | 2002-06-18 |
| RU2002119557A (ru) | 2004-01-10 |
| UY26498A1 (es) | 2001-06-29 |
| EP1242409A2 (en) | 2002-09-25 |
| JO2199B1 (en) | 2003-12-23 |
| AU782920B2 (en) | 2005-09-08 |
| ZA200204313B (en) | 2003-08-29 |
| US6281356B1 (en) | 2001-08-28 |
| CN1411457A (zh) | 2003-04-16 |
| CN1193027C (zh) | 2005-03-16 |
| KR20020062365A (ko) | 2002-07-25 |
| KR100508741B1 (ko) | 2005-08-17 |
| NZ519359A (en) | 2004-04-30 |
| MY133682A (en) | 2007-11-30 |
| CO5090902A1 (es) | 2001-10-30 |
| JP2003518112A (ja) | 2003-06-03 |
| PL357603A1 (en) | 2004-07-26 |
| YU46302A (sh) | 2005-06-10 |
| HUP0204572A2 (en) | 2003-05-28 |
| HK1054382A1 (en) | 2003-11-28 |
| CZ20022492A3 (cs) | 2003-02-12 |
| IL150200A0 (en) | 2002-12-01 |
| AR027035A1 (es) | 2003-03-12 |
| BR0016516A (pt) | 2002-09-17 |
| WO2001046178A2 (en) | 2001-06-28 |
| HRP20020536A2 (en) | 2004-08-31 |
| MA26860A1 (fr) | 2004-12-20 |
| RU2261862C2 (ru) | 2005-10-10 |
| HUP0204572A3 (en) | 2004-07-28 |
| WO2001046178A3 (en) | 2001-12-06 |
| AU3726701A (en) | 2001-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |