PE20001422A1 - Antibioticos cetolidos - Google Patents
Antibioticos cetolidosInfo
- Publication number
- PE20001422A1 PE20001422A1 PE2000000013A PE0000132000A PE20001422A1 PE 20001422 A1 PE20001422 A1 PE 20001422A1 PE 2000000013 A PE2000000013 A PE 2000000013A PE 0000132000 A PE0000132000 A PE 0000132000A PE 20001422 A1 PE20001422 A1 PE 20001422A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cr4r5
- cyane
- alcoxy
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS CETOLIDOS DE FORMULA I, DONDE: X1 ES O, CR4R5, NR4; X2 ES =O, =NOR1; R1 ES H, ALQUILO C1-C1O OPCIONALMENTE REEMPLAZADO CON O, S, NR4, OPCIONALMENTE SUSTITUIDO CON 1-3 COO-ALQUILO C1-C10, ALCOXI C1-C10, NR4R5, S(O)n(ALQUILO C1-C10), ENTRE OTROS; n ES 0-2; R2 ES (CR4R5)n(HETEROCICLO DE 4 A 10 MIEMBROS), (CR4R5)n(ARILO C6-C10); n ES 0-6, SIENDO DE 1-3 R4 O R5 OPCIONALMENTE SUSTITUIDO CON HALOGENO; SIENDO HETEROCICLO Y ARILO OPCIONALMENTE SUSTITUIDOS CON 1-4 R3; R3 ES HALOGENO, CIANO, NITRO, TRIFLUOROMETOXI, TRIFLUOROMETILO, AZIDO, HIDROXI, ALCOXI C1-C6, ALQUILO C1-C10, ALQUENILO C2-C6, ALQUINILO C2-C6, C(O)R6, C(O)OR6, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6; R6 Y R7 SON H, ALQUILO C1-C6, (CR4R5)t(ARILO C6-C10), (CR4R5)t-(HETEROCICLO DE 4 A 10 MIEMBROS) ESTANDO EL GRUPO HETEROCICLO CON OXO Y LOS RESTOS ALQUILO ARILO Y HETEROCICLICO DE R6 Y R7 CON HALOGENO, CIANO, NITRO, NR4R5, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALQUILO C1-C6 ALQUENILO C2-C6, ALQUINILO C2-C6, HIDROXI, ALCOXI C1-C6; t ES 0-5; R8 ES H, CO-ALQUILO C1-C6, BENCILO, BENCILOXICARBONILO, (ALQUIL C1-C6)3SILILO; R9 ES ALQUILO C1-C6; R10 ES H, ALQUILO C1-C10; R11 ES Cl, Br, I, F, CIANO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS CETOLIDOS SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11734299P | 1999-01-27 | 1999-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001422A1 true PE20001422A1 (es) | 2000-12-18 |
Family
ID=22372371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000013A PE20001422A1 (es) | 1999-01-27 | 2000-01-06 | Antibioticos cetolidos |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6833444B2 (es) |
| EP (1) | EP1147121B1 (es) |
| JP (1) | JP3947360B2 (es) |
| KR (1) | KR20020002380A (es) |
| CN (1) | CN1342163A (es) |
| AP (1) | AP2001002222A0 (es) |
| AT (1) | ATE256694T1 (es) |
| AU (1) | AU1675400A (es) |
| BG (1) | BG105730A (es) |
| BR (1) | BR9916969A (es) |
| CA (1) | CA2359708C (es) |
| CO (1) | CO5150229A1 (es) |
| CZ (1) | CZ20012675A3 (es) |
| DE (1) | DE69913738T2 (es) |
| DK (1) | DK1147121T3 (es) |
| DZ (1) | DZ3000A1 (es) |
| EA (1) | EA200100623A1 (es) |
| EE (1) | EE200100394A (es) |
| ES (1) | ES2212655T3 (es) |
| HK (1) | HK1042707A1 (es) |
| HN (1) | HN2000000003A (es) |
| HR (1) | HRP20010559A2 (es) |
| HU (1) | HUP0105190A3 (es) |
| ID (1) | ID30233A (es) |
| IL (1) | IL144178A0 (es) |
| IS (1) | IS5984A (es) |
| MA (1) | MA26717A1 (es) |
| NO (1) | NO20013680L (es) |
| OA (1) | OA11753A (es) |
| PA (1) | PA8489501A1 (es) |
| PE (1) | PE20001422A1 (es) |
| PT (1) | PT1147121E (es) |
| SI (1) | SI1147121T1 (es) |
| SK (1) | SK10172001A3 (es) |
| TN (1) | TNSN00007A1 (es) |
| TR (1) | TR200102128T2 (es) |
| UY (1) | UY25990A1 (es) |
| WO (1) | WO2000044761A2 (es) |
| ZA (1) | ZA200105580B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| OA11753A (en) | 1999-01-27 | 2005-07-19 | Pfizer Prod Inc | Ketolide antibiotics. |
| JP2002542197A (ja) | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| DE60030847T2 (de) | 1999-04-16 | 2007-04-19 | Kosan Biosciences, Inc., Hayward | Antiinfektiöse makrolidderivate |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| AP2001002302A0 (en) | 1999-05-24 | 2001-10-25 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
| DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
| US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| WO2002050091A1 (en) * | 2000-12-21 | 2002-06-27 | Glaxo Group Limited | Macrolide antibiotics |
| WO2003022289A1 (fr) * | 2001-09-05 | 2003-03-20 | Hokuriku Seiyaku Co., Ltd. | Medicament contenant de l'erythromycine pour traiter ou prevenir la tuberculose |
| ES2552682T3 (es) | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
| JP2008508322A (ja) * | 2004-07-28 | 2008-03-21 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤としてのケトライド誘導体 |
| UA85937C2 (uk) | 2004-12-21 | 2009-03-10 | Пфайзер Продактс Інк. | Макроліди |
| US8124744B2 (en) * | 2006-05-01 | 2012-02-28 | Taisho Pharmaceutical Co., Ltd. | Macrolide derivatives |
| EP2214484A4 (en) | 2007-10-25 | 2013-01-02 | Cempra Pharmaceuticals Inc | PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS |
| EP2358379B1 (en) | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| DK2550286T3 (en) | 2010-03-22 | 2016-02-29 | Cempra Pharmaceuticals Inc | CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF |
| EP2571506B1 (en) | 2010-05-20 | 2017-05-10 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES |
| KR20140139083A (ko) | 2012-03-27 | 2014-12-04 | 셈프라 파마슈티컬스, 인크. | 마크롤라이드계 항생제를 투여하기 위한 비경구 제제 |
| JP6426696B2 (ja) | 2013-03-14 | 2018-11-21 | センプラ ファーマシューティカルズ，インコーポレイテッド | 呼吸器疾患の治療のための方法および製剤 |
| EP2968384A4 (en) | 2013-03-15 | 2017-02-15 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
| WO2014156549A1 (ja) | 2013-03-28 | 2014-10-02 | 不二製油株式会社 | 緑豆蛋白ゲル状組成物及びチーズ様食品 |
| CN106518939B (zh) * | 2015-09-14 | 2019-12-31 | 江苏奥赛康药业有限公司 | 一种制备Solithromycin化合物的方法 |
| CN110234323A (zh) * | 2016-10-04 | 2019-09-13 | Ti生物制药有限公司 | 具有抗菌活性的酮内酯 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| US5141926A (en) | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| IL99995A (en) | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2697524B1 (fr) | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2727969B1 (fr) * | 1994-12-09 | 1997-01-17 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| US5747466A (en) | 1995-11-08 | 1998-05-05 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2745290B1 (fr) | 1996-02-28 | 1998-04-03 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| WO1998001546A2 (en) | 1996-07-05 | 1998-01-15 | Biotica Technology Limited | Polyketides and their synthesis |
| FR2751656B1 (fr) | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| FR2757168B1 (fr) | 1996-12-12 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| FR2760017B1 (fr) | 1997-02-27 | 1999-04-30 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments |
| US6165986A (en) | 1997-03-10 | 2000-12-26 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
| US20020025937A1 (en) | 2000-03-20 | 2002-02-28 | Yong-Jin Wu | 9-oxime erythromycin derivatives |
| ZA987689B (en) | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
| AU9649598A (en) | 1997-10-29 | 1999-05-17 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a, 11,12-carbamate derivatives |
| HN1998000159A (es) | 1997-10-29 | 1999-02-09 | Monsanto Co | Derivados de 9- amino - 3 ceto eritromicina |
| WO1999025385A1 (en) | 1997-11-17 | 1999-05-27 | Imarx Pharmaceutical Corp. | A method of increasing nucleic acid synthesis with ultrasound |
| FR2771008B1 (fr) * | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
| EP1115732B1 (en) | 1998-09-22 | 2005-06-29 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
| US6100240A (en) | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
| FR2785612A1 (fr) | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| CA2349338C (en) | 1998-11-03 | 2005-12-06 | Pfizer Products Inc. | Novel macrolide antibiotics |
| FR2786188B1 (fr) | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
| EP1137654A1 (en) | 1998-12-10 | 2001-10-04 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
| OA11753A (en) | 1999-01-27 | 2005-07-19 | Pfizer Prod Inc | Ketolide antibiotics. |
| FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| DE60030847T2 (de) | 1999-04-16 | 2007-04-19 | Kosan Biosciences, Inc., Hayward | Antiinfektiöse makrolidderivate |
| JP2002542197A (ja) | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
| US6355620B1 (en) | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
| AP2001002302A0 (en) | 1999-05-24 | 2001-10-25 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
| EP1114826A3 (en) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| EP1122261A3 (en) | 2000-01-31 | 2001-09-26 | Pfizer Products Inc. | 13 and 14-membered antibacterial macrolides |
| US20020061856A1 (en) | 2000-04-24 | 2002-05-23 | Yong-Jin Wu | Novel tricyclic erythromycin derivatives |
| DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
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1999
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- 1999-12-28 CN CN99815909A patent/CN1342163A/zh active Pending
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2000
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2001
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