HUP0105190A2 - Ketolid antibiotikumok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Ketolid antibiotikumok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0105190A2
HUP0105190A2 HU0105190A HUP0105190A HUP0105190A2 HU P0105190 A2 HUP0105190 A2 HU P0105190A2 HU 0105190 A HU0105190 A HU 0105190A HU P0105190 A HUP0105190 A HU P0105190A HU P0105190 A2 HUP0105190 A2 HU P0105190A2
Authority
HU
Hungary
Prior art keywords
formula
alkyl
group
cr4r5
compounds
Prior art date
Application number
HU0105190A
Other languages
English (en)
Inventor
Takushi Kaneko
William Thomas Mcmillen
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0105190A2 publication Critical patent/HUP0105190A2/hu
Publication of HUP0105190A3 publication Critical patent/HUP0105190A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

A tal lm ny t rgy t (1) ltal nos képletű vegyületek és ezekgyógyszerészetileg elfogadható sói és szolv tjai képezik, amelyekképletében X1, X2, R2, R8, R9, R10 és R11 jelentése az al bbiakbanmegadott. Az (1) ltal nos képletű vegyületek antibakteri lis ésprotozoon-ellenes hat sú szerek és így kül"nféle bakteri lis ésprotozoon lis fertőzések kezelésére haszn lhatóak. A tal lm ny t rgy tképezik tov bb az (1) ltal nos képletű vegyületeket tartalmazógyógyszerkészítmények és az (1) ltal nos képletű vegyületek adagol sval végzett, bakteri lis és protozoon lis fertőzések kezelésére szolgló elj r sok. X1 jelentése O, -CR4R5- vagy -NR4 ltal nos képletűcsoport; X2 jelentése =O vagy =NOR ltal nos képletű csoport; R1jelentése hidrogénatom vagy 1-10 szénatomos alkilcsoport; R2 jelentése-(CR4R5)n (4-10 tagból lló heterocilus)- vagy -(CR4R5)n (6-10 tagbóllló aril)csoport; R4 és R5 jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport; R8 jelentése hidrogénatom, -C(O)(1-6 szénatomos alkil)-,benzil-, benzil-oxi-karbonil- vagy (1-6 szénatomos alkil)3-szililcsoport; R9 jelentése 1-6 szénatomos alkilcsoport, R10 jelentésehidrogénatom vagy 1-10 szénatomos alkilcsoport. Ó
HU0105190A 1999-01-27 1999-12-28 Ketolide antibiotics, medicaments containing them and their use HUP0105190A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11734299P 1999-01-27 1999-01-27
PCT/IB1999/002051 WO2000044761A2 (en) 1999-01-27 1999-12-28 Ketolide antibiotics

Publications (2)

Publication Number Publication Date
HUP0105190A2 true HUP0105190A2 (hu) 2002-04-29
HUP0105190A3 HUP0105190A3 (en) 2003-03-28

Family

ID=22372371

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105190A HUP0105190A3 (en) 1999-01-27 1999-12-28 Ketolide antibiotics, medicaments containing them and their use

Country Status (39)

Country Link
US (1) US6833444B2 (hu)
EP (1) EP1147121B1 (hu)
JP (1) JP3947360B2 (hu)
KR (1) KR20020002380A (hu)
CN (1) CN1342163A (hu)
AP (1) AP2001002222A0 (hu)
AT (1) ATE256694T1 (hu)
AU (1) AU1675400A (hu)
BG (1) BG105730A (hu)
BR (1) BR9916969A (hu)
CA (1) CA2359708C (hu)
CO (1) CO5150229A1 (hu)
CZ (1) CZ20012675A3 (hu)
DE (1) DE69913738T2 (hu)
DK (1) DK1147121T3 (hu)
DZ (1) DZ3000A1 (hu)
EA (1) EA200100623A1 (hu)
EE (1) EE200100394A (hu)
ES (1) ES2212655T3 (hu)
HK (1) HK1042707A1 (hu)
HN (1) HN2000000003A (hu)
HR (1) HRP20010559A2 (hu)
HU (1) HUP0105190A3 (hu)
ID (1) ID30233A (hu)
IL (1) IL144178A0 (hu)
IS (1) IS5984A (hu)
MA (1) MA26717A1 (hu)
NO (1) NO20013680L (hu)
OA (1) OA11753A (hu)
PA (1) PA8489501A1 (hu)
PE (1) PE20001422A1 (hu)
PT (1) PT1147121E (hu)
SI (1) SI1147121T1 (hu)
SK (1) SK10172001A3 (hu)
TN (1) TNSN00007A1 (hu)
TR (1) TR200102128T2 (hu)
UY (1) UY25990A1 (hu)
WO (1) WO2000044761A2 (hu)
ZA (1) ZA200105580B (hu)

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Also Published As

Publication number Publication date
CA2359708C (en) 2005-10-25
EP1147121B1 (en) 2003-12-17
WO2000044761A2 (en) 2000-08-03
NO20013680D0 (no) 2001-07-26
HUP0105190A3 (en) 2003-03-28
HK1042707A1 (zh) 2002-08-23
JP2002535414A (ja) 2002-10-22
DE69913738D1 (de) 2004-01-29
CN1342163A (zh) 2002-03-27
PE20001422A1 (es) 2000-12-18
WO2000044761A3 (en) 2001-01-04
TR200102128T2 (tr) 2001-12-21
TNSN00007A1 (fr) 2005-11-10
CA2359708A1 (en) 2000-08-03
NO20013680L (no) 2001-09-19
SI1147121T1 (en) 2004-04-30
PT1147121E (pt) 2004-04-30
SK10172001A3 (sk) 2002-06-04
OA11753A (en) 2005-07-19
DZ3000A1 (fr) 2004-03-27
EA200100623A1 (ru) 2002-02-28
CO5150229A1 (es) 2002-04-29
HN2000000003A (es) 2001-02-02
ID30233A (id) 2001-11-15
AU1675400A (en) 2000-08-18
UY25990A1 (es) 2000-09-29
US20020156027A1 (en) 2002-10-24
DE69913738T2 (de) 2004-06-17
ZA200105580B (en) 2003-02-17
KR20020002380A (ko) 2002-01-09
IS5984A (is) 2001-06-28
EE200100394A (et) 2002-10-15
PA8489501A1 (es) 2000-09-29
JP3947360B2 (ja) 2007-07-18
IL144178A0 (en) 2002-05-23
EP1147121A2 (en) 2001-10-24
BR9916969A (pt) 2001-11-06
ES2212655T3 (es) 2004-07-16
MA26717A1 (fr) 2004-12-20
BG105730A (en) 2002-03-29
AP2001002222A0 (en) 2001-09-30
CZ20012675A3 (cs) 2002-04-17
HRP20010559A2 (en) 2002-08-31
US6833444B2 (en) 2004-12-21
DK1147121T3 (da) 2004-04-13
ATE256694T1 (de) 2004-01-15

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