BR9916969A - Antibióticos cetólidos - Google Patents

Antibióticos cetólidos

Info

Publication number
BR9916969A
BR9916969A BR9916969-0A BR9916969A BR9916969A BR 9916969 A BR9916969 A BR 9916969A BR 9916969 A BR9916969 A BR 9916969A BR 9916969 A BR9916969 A BR 9916969A
Authority
BR
Brazil
Prior art keywords
formula
compounds
infections
relates
antibiotics
Prior art date
Application number
BR9916969-0A
Other languages
English (en)
Inventor
Takushi Kaneko
William Thomas Mcmillen
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9916969A publication Critical patent/BR9916969A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Patente de Invenção: "ANTIBIóTICOS CETóLIDOS". Esta invenção refere-se ao compostos de fórmula <UM>1<MV> e com os seus sais e solvatos farmaceuticamente aceitáveis em que X^ 1^, X^ 2^, R^ 2^, R^ 8^, R^ 9^, R^ 10^ e R^ 11^ são definidos como anteriormente. Os compostos de fórmula <UM>1<MV> são agentes antibacterianos e antiprotozoários que podem ser utilizados para o tratamento de várias infecções bacterianas e de protozoários e de patologias relacionadas com tais infecções. A invenção também está relacionada com composições farmacêuticas que contêm os compostos de fórmula <UM>1<MV> e com métodos de tratamento de infecções bacterianas e de protozoários por administração de compostos de fórmula <UM>1<MV>.
BR9916969-0A 1999-01-27 1999-12-28 Antibióticos cetólidos BR9916969A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11734299P 1999-01-27 1999-01-27
PCT/IB1999/002051 WO2000044761A2 (en) 1999-01-27 1999-12-28 Ketolide antibiotics

Publications (1)

Publication Number Publication Date
BR9916969A true BR9916969A (pt) 2001-11-06

Family

ID=22372371

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916969-0A BR9916969A (pt) 1999-01-27 1999-12-28 Antibióticos cetólidos

Country Status (39)

Country Link
US (1) US6833444B2 (pt)
EP (1) EP1147121B1 (pt)
JP (1) JP3947360B2 (pt)
KR (1) KR20020002380A (pt)
CN (1) CN1342163A (pt)
AP (1) AP2001002222A0 (pt)
AT (1) ATE256694T1 (pt)
AU (1) AU1675400A (pt)
BG (1) BG105730A (pt)
BR (1) BR9916969A (pt)
CA (1) CA2359708C (pt)
CO (1) CO5150229A1 (pt)
CZ (1) CZ20012675A3 (pt)
DE (1) DE69913738T2 (pt)
DK (1) DK1147121T3 (pt)
DZ (1) DZ3000A1 (pt)
EA (1) EA200100623A1 (pt)
EE (1) EE200100394A (pt)
ES (1) ES2212655T3 (pt)
HK (1) HK1042707A1 (pt)
HN (1) HN2000000003A (pt)
HR (1) HRP20010559A2 (pt)
HU (1) HUP0105190A3 (pt)
ID (1) ID30233A (pt)
IL (1) IL144178A0 (pt)
IS (1) IS5984A (pt)
MA (1) MA26717A1 (pt)
NO (1) NO20013680L (pt)
OA (1) OA11753A (pt)
PA (1) PA8489501A1 (pt)
PE (1) PE20001422A1 (pt)
PT (1) PT1147121E (pt)
SI (1) SI1147121T1 (pt)
SK (1) SK10172001A3 (pt)
TN (1) TNSN00007A1 (pt)
TR (1) TR200102128T2 (pt)
UY (1) UY25990A1 (pt)
WO (1) WO2000044761A2 (pt)
ZA (1) ZA200105580B (pt)

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AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
OA11753A (en) 1999-01-27 2005-07-19 Pfizer Prod Inc Ketolide antibiotics.
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
DE60030847T2 (de) 1999-04-16 2007-04-19 Kosan Biosciences, Inc., Hayward Antiinfektiöse makrolidderivate
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
DK1167376T3 (da) 2000-06-30 2004-10-25 Pfizer Prod Inc Makrolidantibiotika
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
WO2002050091A1 (en) * 2000-12-21 2002-06-27 Glaxo Group Limited Macrolide antibiotics
WO2003022289A1 (fr) * 2001-09-05 2003-03-20 Hokuriku Seiyaku Co., Ltd. Medicament contenant de l'erythromycine pour traiter ou prevenir la tuberculose
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
UA85937C2 (uk) 2004-12-21 2009-03-10 Пфайзер Продактс Інк. Макроліди
US8124744B2 (en) * 2006-05-01 2012-02-28 Taisho Pharmaceutical Co., Ltd. Macrolide derivatives
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
EP2358379B1 (en) 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2014156549A1 (ja) 2013-03-28 2014-10-02 不二製油株式会社 緑豆蛋白ゲル状組成物及びチーズ様食品
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN110234323A (zh) * 2016-10-04 2019-09-13 Ti生物制药有限公司 具有抗菌活性的酮内酯

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FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
CA2349338C (en) 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
FR2786188B1 (fr) 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
OA11753A (en) 1999-01-27 2005-07-19 Pfizer Prod Inc Ketolide antibiotics.
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DE60030847T2 (de) 1999-04-16 2007-04-19 Kosan Biosciences, Inc., Hayward Antiinfektiöse makrolidderivate
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
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Also Published As

Publication number Publication date
TR200102128T2 (tr) 2001-12-21
US20020156027A1 (en) 2002-10-24
UY25990A1 (es) 2000-09-29
SI1147121T1 (en) 2004-04-30
CZ20012675A3 (cs) 2002-04-17
EE200100394A (et) 2002-10-15
TNSN00007A1 (fr) 2005-11-10
OA11753A (en) 2005-07-19
EP1147121A2 (en) 2001-10-24
PE20001422A1 (es) 2000-12-18
DK1147121T3 (da) 2004-04-13
IL144178A0 (en) 2002-05-23
WO2000044761A3 (en) 2001-01-04
NO20013680D0 (no) 2001-07-26
AU1675400A (en) 2000-08-18
EP1147121B1 (en) 2003-12-17
ZA200105580B (en) 2003-02-17
PT1147121E (pt) 2004-04-30
CO5150229A1 (es) 2002-04-29
HN2000000003A (es) 2001-02-02
ATE256694T1 (de) 2004-01-15
HUP0105190A2 (hu) 2002-04-29
DE69913738D1 (de) 2004-01-29
SK10172001A3 (sk) 2002-06-04
HUP0105190A3 (en) 2003-03-28
ES2212655T3 (es) 2004-07-16
KR20020002380A (ko) 2002-01-09
AP2001002222A0 (en) 2001-09-30
BG105730A (en) 2002-03-29
ID30233A (id) 2001-11-15
WO2000044761A2 (en) 2000-08-03
EA200100623A1 (ru) 2002-02-28
PA8489501A1 (es) 2000-09-29
IS5984A (is) 2001-06-28
CA2359708C (en) 2005-10-25
CN1342163A (zh) 2002-03-27
US6833444B2 (en) 2004-12-21
HK1042707A1 (zh) 2002-08-23
MA26717A1 (fr) 2004-12-20
HRP20010559A2 (en) 2002-08-31
JP3947360B2 (ja) 2007-07-18
CA2359708A1 (en) 2000-08-03
DE69913738T2 (de) 2004-06-17
DZ3000A1 (fr) 2004-03-27
JP2002535414A (ja) 2002-10-22
NO20013680L (no) 2001-09-19

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