BR9802851A - Antibióticos de macrolìdeo substituìdos por c-4 - Google Patents

Antibióticos de macrolìdeo substituìdos por c-4

Info

Publication number
BR9802851A
BR9802851A BR9802851-0A BR9802851A BR9802851A BR 9802851 A BR9802851 A BR 9802851A BR 9802851 A BR9802851 A BR 9802851A BR 9802851 A BR9802851 A BR 9802851A
Authority
BR
Brazil
Prior art keywords
compounds
formula
macrolide antibiotics
replaced
infections
Prior art date
Application number
BR9802851-0A
Other languages
English (en)
Inventor
Katherine Elizabeth Brighty
Takushi Kaneko
Robert Gerald Ii Linde
Hiroko Masamune
Paul Robert Mcguirk
Wei-Guo Su
Yong-Jin Wu
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9802851A publication Critical patent/BR9802851A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"ANTIBIóTICOS DE MACROLìDEO SUBSTITUìDOS POR C-4"<D> Esta invenção refere-se a compostos da fórmula e a sais farmaceuticamente aceitáveis dos mesmos. Os compostos da fórmula <MU>1<MV> são agentes antibacterianos e antiprotozoários potentes que podem ser usados para tratar várias infecções bacterianas e protozoários e distúrbios relacionados a tais infecções. A invenção também refere-se as composições farmacêuticas contendo os compostos da fórmula <MU>1<MV> e aos processos de tratamento de infecções bacterianas e protozoárias por administração dos compostos da fórmula <MU>1<MV>.
BR9802851-0A 1997-08-06 1998-08-05 Antibióticos de macrolìdeo substituìdos por c-4 BR9802851A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5486697P 1997-08-06 1997-08-06

Publications (1)

Publication Number Publication Date
BR9802851A true BR9802851A (pt) 2000-08-29

Family

ID=21994012

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9802851-0A BR9802851A (pt) 1997-08-06 1998-08-05 Antibióticos de macrolìdeo substituìdos por c-4

Country Status (5)

Country Link
US (2) US6025350A (pt)
EP (1) EP0895999A1 (pt)
JP (1) JP3441377B2 (pt)
BR (1) BR9802851A (pt)
CA (1) CA2244519C (pt)

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FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
CA2349338C (en) * 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
AR023264A1 (es) * 1999-04-08 2002-09-04 Hokuriku Pharmaceutical Derivados de eritromicina
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
DE60138876D1 (de) * 2000-03-28 2009-07-16 Sandoz Ag Geschmackmaskierte granulierte teilchen
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US20020198207A1 (en) * 2000-05-18 2002-12-26 Kath John Charles Novel Hexanoic acid derivatives
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
JP4311203B2 (ja) * 2001-08-08 2009-08-12 大正製薬株式会社 １１ａ−アザライド化合物及びその製造方法
WO2003022289A1 (fr) * 2001-09-05 2003-03-20 Hokuriku Seiyaku Co., Ltd. Medicament contenant de l'erythromycine pour traiter ou prevenir la tuberculose
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
EP1482957A4 (en) 2002-02-15 2006-07-19 Merckle Gmbh ANTIBIOTIC CONJUGATES
US20040005641A1 (en) * 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2476423A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1479687A4 (en) * 2002-02-26 2006-01-04 Meiji Seika Kaisha A NEW LOW-GYLIC CYCLIC AZALIDE, A NEW 16-LOW CYCLIC DIAZALID DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF
BR0312584A (pt) * 2002-07-08 2005-04-12 Pliva Istrazivacki Inst D O O Novas substâncias anti-inflamatórias não-esteróides, compostos e métodos para o uso das mesmas
PL375162A1 (en) 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
GB0225384D0 (en) * 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds
US20060141470A1 (en) * 2003-02-14 2006-06-29 Kalayoglu Murat V Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
KR20060002800A (ko) * 2003-03-05 2006-01-09 립-엑스 파마슈티칼즈, 인크. 이관능성 헤테로시클릭 화합물, 및 그의 제조 및 사용 방법
GB0310962D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
CA2525455A1 (en) * 2003-05-13 2004-11-25 Glaxo Group Limited Novel 14 and 15 membered-ring compounds
GB0310979D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
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GB0310980D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
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UA85937C2 (uk) 2004-12-21 2009-03-10 Пфайзер Продактс Інк. Макроліди
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RU2008106915A (ru) * 2005-07-26 2009-09-10 Меркле Гмбх (De) Макролидные конъюгаты пирролиновых и индолизиновых соединений
JPWO2009019868A1 (ja) 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
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CN101906123B (zh) * 2010-01-12 2013-04-10 山东大学 4″-芳烷基氨基甲酸酯克拉霉素衍生物及其制备方法和应用
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MX2015006340A (es) * 2012-11-21 2015-09-07 Rqx Pharmaceuticals Inc Antibioticos macrociclicos de amplio espectro.
CN103288897B (zh) * 2013-06-18 2015-10-21 山东大学 4”-o-(1-芳烷基-1,2,3-三氮唑-4-甲基-氨基甲酰基)阿奇霉素衍生物
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Also Published As

Publication number Publication date
US6300316B1 (en) 2001-10-09
JPH11116593A (ja) 1999-04-27
CA2244519C (en) 2002-07-09
US6025350A (en) 2000-02-15
CA2244519A1 (en) 1999-02-06
EP0895999A1 (en) 1999-02-10
JP3441377B2 (ja) 2003-09-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.