ATE268337T1 - C11-carbamate von antibakteriellen makroliden - Google Patents

C11-carbamate von antibakteriellen makroliden

Info

Publication number
ATE268337T1
ATE268337T1 AT99306034T AT99306034T ATE268337T1 AT E268337 T1 ATE268337 T1 AT E268337T1 AT 99306034 T AT99306034 T AT 99306034T AT 99306034 T AT99306034 T AT 99306034T AT E268337 T1 ATE268337 T1 AT E268337T1
Authority
AT
Austria
Prior art keywords
compounds
formula
relates
macrolids
carbamates
Prior art date
Application number
AT99306034T
Other languages
English (en)
Inventor
Hengmiao Cheng
Michael Anthony Letavic
Carl Bernard Ziegler
Jason Kenneth Dutra
Peter Bertinato
Brian Scott Bronk
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE268337T1 publication Critical patent/ATE268337T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99306034T 1998-08-19 1999-07-29 C11-carbamate von antibakteriellen makroliden ATE268337T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9707598P 1998-08-19 1998-08-19
US10478598P 1998-10-19 1998-10-19

Publications (1)

Publication Number Publication Date
ATE268337T1 true ATE268337T1 (de) 2004-06-15

Family

ID=26792507

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99306034T ATE268337T1 (de) 1998-08-19 1999-07-29 C11-carbamate von antibakteriellen makroliden

Country Status (10)

Country Link
US (1) US6043227A (de)
EP (1) EP0984019B1 (de)
JP (1) JP2000063397A (de)
AT (1) ATE268337T1 (de)
BR (1) BR9903737A (de)
CA (1) CA2280328C (de)
DE (1) DE69917717T2 (de)
DK (1) DK0984019T3 (de)
ES (1) ES2220008T3 (de)
PT (1) PT984019E (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710033B1 (en) 1996-08-14 2004-03-23 Vanderbilt University Methods and treatment of multiple sclerosis
US6890526B2 (en) 1997-05-06 2005-05-10 Vanderbilt University Methods and reagents for the treatment of multiple sclerosis
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
EP1101769A3 (de) 1999-11-18 2001-10-24 Pfizer Products Inc. Stickstoff-enthaltend Erythromycin-Derivate
WO2001070239A1 (en) * 2000-03-22 2001-09-27 Thomas Jefferson University Use of azithromycin for infections with leishmania
AU2003211113B2 (en) * 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
EP1483277A4 (de) 2002-02-15 2007-10-03 Merckle Gmbh Konjugate biologisch aktiver verbindungen, verfahren zu deren herstellung und anwendung, formulierung und pharmazeutische anwendungen davon
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070173A2 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
RS20050007A (sr) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., NOVE NESTEROIDNE-ANTI- INFLAMATORNE SUPSTANCE, KOMPOZICIJE I POSTUPCI ZA NjIHOVU UPOTREBU
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
WO2004005310A2 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
JP2009502838A (ja) * 2005-07-26 2009-01-29 メルクレ，ゲーエムベーハー ピロリジンおよびインドリジン化合物のマクロライド接合体
CN101423539B (zh) * 2008-12-09 2011-04-27 山东大学 4″,11-二氨基甲酸酯阿奇霉素衍生物、制备方法及其药物组合物
FR2995605B1 (fr) * 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.
CN104844671B (zh) * 2015-05-19 2017-07-04 山东大学 11‑o‑芳烷基氨基甲酸酯克拉霉素衍生物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4921839A (en) * 1987-02-24 1990-05-01 Beecham Group P.L.C. Erythromycin a 11,12-carbonate 9-oxime derivatives
CA2094060A1 (en) * 1990-10-15 1992-04-16 Toshifumi Asaka 2'-position modified compound of erythromycin or its derivative
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
HRP970714B1 (en) * 1997-12-31 2003-08-31 Pliva Pharm & Chem Works Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.

Also Published As

Publication number Publication date
US6043227A (en) 2000-03-28
PT984019E (pt) 2004-08-31
EP0984019A1 (de) 2000-03-08
BR9903737A (pt) 2000-09-19
JP2000063397A (ja) 2000-02-29
ES2220008T3 (es) 2004-12-01
CA2280328C (en) 2005-07-26
DK0984019T3 (da) 2004-08-30
EP0984019B1 (de) 2004-06-02
DE69917717T2 (de) 2004-09-23
CA2280328A1 (en) 2000-02-19
DE69917717D1 (de) 2004-07-08

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