MX2015006340A - Antibioticos macrociclicos de amplio espectro. - Google Patents

Antibioticos macrociclicos de amplio espectro.

Info

Publication number
MX2015006340A
MX2015006340A MX2015006340A MX2015006340A MX2015006340A MX 2015006340 A MX2015006340 A MX 2015006340A MX 2015006340 A MX2015006340 A MX 2015006340A MX 2015006340 A MX2015006340 A MX 2015006340A MX 2015006340 A MX2015006340 A MX 2015006340A
Authority
MX
Mexico
Prior art keywords
broad spectrum
compounds
spectrum antibiotics
macrocyclic
macrocyclic broad
Prior art date
Application number
MX2015006340A
Other languages
English (en)
Inventor
Robert I Higuchi
Tucker Curran Roberts
Peter Andrew Smith
David Campbell
Prasuna Paraselli
Original Assignee
Rqx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rqx Pharmaceuticals Inc filed Critical Rqx Pharmaceuticals Inc
Publication of MX2015006340A publication Critical patent/MX2015006340A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a compuestos antibacterianos que en algunas formas de realización tienen un amplio espectro de bioactividad. En diversas formas de realización, los compuestos actúan por inhibición de la peptidasa de señal (SpsB) del tipo bacteriano 1, una proteína esencial de las bacterias. También se proveen composiciones farmacéuticas y métodos de tratamiento en los que se usan los compuestos.
MX2015006340A 2012-11-21 2013-11-20 Antibioticos macrociclicos de amplio espectro. MX2015006340A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261729253P 2012-11-21 2012-11-21
US201261729249P 2012-11-21 2012-11-21
PCT/US2013/071093 WO2014081886A1 (en) 2012-11-21 2013-11-20 Macrocyclic broad spectrum antibiotics

Publications (1)

Publication Number Publication Date
MX2015006340A true MX2015006340A (es) 2015-09-07

Family

ID=50728492

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006340A MX2015006340A (es) 2012-11-21 2013-11-20 Antibioticos macrociclicos de amplio espectro.

Country Status (12)

Country Link
US (1) US9309285B2 (es)
EP (1) EP2922829B1 (es)
JP (2) JP6437443B2 (es)
KR (1) KR20150088292A (es)
CN (1) CN104903302B (es)
AR (1) AR093581A1 (es)
BR (1) BR112015011697A2 (es)
CA (1) CA2892027A1 (es)
EA (1) EA201590871A1 (es)
MX (1) MX2015006340A (es)
TW (1) TWI631127B (es)
WO (1) WO2014081886A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EP2984166B1 (en) 2013-03-15 2020-04-22 The Trustees Of The University Of Pennsylvania Compositions for treating mpsi
BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
EP3289355A4 (en) * 2015-04-30 2019-02-13 IDEXX Laboratories, Inc. METHODS OF DETECTING RENAL DISEASE
MY193014A (en) 2015-10-27 2022-09-22 Hoffmann La Roche Peptide macrocycles against acinetobacter baumannii
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
KR20180109858A (ko) * 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
UA126027C2 (uk) * 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
RS64852B1 (sr) * 2019-05-28 2023-12-29 Hoffmann La Roche Makrociklični antibiotici širokog spektra

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204328A (en) 1990-06-26 1993-04-20 Merck & Co., Inc. Peptides having atrial natriuretic factor activity
EP0895999A1 (en) * 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
US6660832B1 (en) * 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
AU2004252174A1 (en) 2003-06-26 2005-01-06 Migenix Inc. Compositions of lipopeptide antibiotic derivatives and methods of use thereof
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
CA2791732A1 (en) * 2010-03-09 2011-09-15 Scott K. Smith Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
AU2010350241A1 (en) 2010-04-01 2012-10-25 The University Of Queensland Oxytocin peptide analogues
WO2012036907A2 (en) * 2010-09-15 2012-03-22 Romesberg Floyd E Broad spectrum antibiotic arylomycin analogs
WO2012166665A2 (en) 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
EA201491646A1 (ru) 2012-03-14 2015-03-31 Дзе Скриппс Рисёч Инститьют Аналоги антибиотика ариломицина широкого действия

Also Published As

Publication number Publication date
WO2014081886A1 (en) 2014-05-30
CN104903302A (zh) 2015-09-09
EP2922829B1 (en) 2021-08-11
TW201434848A (zh) 2014-09-16
JP2016501864A (ja) 2016-01-21
EP2922829A4 (en) 2016-11-02
JP6662960B2 (ja) 2020-03-11
EP2922829A1 (en) 2015-09-30
CN104903302B (zh) 2019-03-29
CA2892027A1 (en) 2014-05-30
US20140142029A1 (en) 2014-05-22
JP6437443B2 (ja) 2018-12-12
JP2018184435A (ja) 2018-11-22
US9309285B2 (en) 2016-04-12
KR20150088292A (ko) 2015-07-31
BR112015011697A2 (pt) 2017-07-11
TWI631127B (zh) 2018-08-01
EA201590871A1 (ru) 2015-11-30
AR093581A1 (es) 2015-06-10

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