MX2018006199A - Antibioticos de amplio espectro macrociclico. - Google Patents

Antibioticos de amplio espectro macrociclico.

Info

Publication number
MX2018006199A
MX2018006199A MX2018006199A MX2018006199A MX2018006199A MX 2018006199 A MX2018006199 A MX 2018006199A MX 2018006199 A MX2018006199 A MX 2018006199A MX 2018006199 A MX2018006199 A MX 2018006199A MX 2018006199 A MX2018006199 A MX 2018006199A
Authority
MX
Mexico
Prior art keywords
broad spectrum
compounds
spectrum antibiotics
macrocyclic
macrocyclic broad
Prior art date
Application number
MX2018006199A
Other languages
English (en)
Inventor
Bradley Schwarz Jacob
John Crawford James
I Higuchi Robert
Andrew Smith Peter
Yu Zhiyong
Chen Yongsheng
F T Koehler Michael
Curran Roberts Tucker
Paraselli Prasuna
Q Ly Cuong
Hu Huiyong
Original Assignee
Rqx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rqx Pharmaceuticals Inc filed Critical Rqx Pharmaceuticals Inc
Publication of MX2018006199A publication Critical patent/MX2018006199A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Abstract

Se proporcionan aquí compuestos antibacterianos, en los que los compuestos en algunas realizaciones tienen una bioactividad de amplio espectro, los compuestos actúan por inhibición de la peptidasa de señalización de tipo 1 bacteriana (SpsB), una proteína esencial en bacterias. También se proporcionan composiciones farmacéuticas y métodos para el tratamiento que usan los compuestos descritos aquí.
MX2018006199A 2015-11-20 2016-11-21 Antibioticos de amplio espectro macrociclico. MX2018006199A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (1)

Publication Number Publication Date
MX2018006199A true MX2018006199A (es) 2019-01-10

Family

ID=58231314

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006199A MX2018006199A (es) 2015-11-20 2016-11-21 Antibioticos de amplio espectro macrociclico.

Country Status (12)

Country Link
US (1) US11072635B2 (es)
EP (1) EP3377474B1 (es)
JP (1) JP6873993B2 (es)
KR (1) KR20180109858A (es)
CN (1) CN109219596B (es)
AU (1) AU2016357926B2 (es)
BR (1) BR112018010267A2 (es)
CA (1) CA3005551A1 (es)
IL (1) IL259429B (es)
MX (1) MX2018006199A (es)
RU (1) RU2761476C2 (es)
WO (1) WO2017084629A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
CA2949681A1 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
PE20191618A1 (es) * 2017-02-15 2019-11-05 Rqx Pharmaceuticals Inc Antibioticos macrociclicos de amplio espectro
MA50664A (fr) * 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
PE20230383A1 (es) 2019-05-28 2023-03-06 Hoffmann La Roche Antibioticos macrociclicos de amplio espectro

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BR9712544B1 (pt) 1996-10-18 2013-10-22 Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos
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DE102005014247A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
KR20130044382A (ko) 2010-03-01 2013-05-02 마이렉시스 인코포레이티드 화합물 및 그의 치료 용도
KR20130028078A (ko) * 2010-03-09 2013-03-18 머크 캐나다 인크. 베타-락탐 항박테리아제의 활성을 강화시키는 가교된 리포글리코펩티드
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EP2616093A4 (en) 2010-09-15 2014-02-26 Scripps Research Inst IN A WIDE SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGUE
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
US20140249073A1 (en) 2011-05-27 2014-09-04 Rqx Pharmaceuticals, Inc Broad spectrum antibiotics
CN103159830B (zh) 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
FR2986154B1 (fr) 2012-01-31 2017-08-04 Pierre Fabre Dermo-Cosmetique Nouveau systeme photoprotecteur
WO2013138187A1 (en) 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
CN103788176A (zh) * 2012-10-31 2014-05-14 上海来益生物药物研究开发中心有限责任公司 一种arylomycin类化合物及其制备方法和应用
MX2015006340A (es) * 2012-11-21 2015-09-07 Rqx Pharmaceuticals Inc Antibioticos macrociclicos de amplio espectro.
CA2949681A1 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
ITUB20154591A1 (it) 2015-10-12 2017-04-12 Crestoptics S R L Apparato di microscopia confocale e relativo procedimento di acquisizione ed elaborazione di immagini
TWI725075B (zh) * 2015-11-20 2021-04-21 美商Ｒｑｘ製藥公司 巨環廣效抗生素
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
PE20191618A1 (es) 2017-02-15 2019-11-05 Rqx Pharmaceuticals Inc Antibioticos macrociclicos de amplio espectro
MX2019011517A (es) 2017-03-27 2019-11-18 Hoffmann La Roche Proceso para producir analogos de anillo de arilomicina.
MA50664A (fr) 2017-09-29 2020-08-05 Genentech Inc Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
PE20230383A1 (es) 2019-05-28 2023-03-06 Hoffmann La Roche Antibioticos macrociclicos de amplio espectro

Also Published As

Publication number Publication date
CN109219596A (zh) 2019-01-15
AU2016357926B2 (en) 2021-05-27
WO2017084629A1 (en) 2017-05-26
IL259429A (en) 2018-07-31
RU2018122498A3 (es) 2020-02-28
AU2016357926A1 (en) 2018-06-14
CA3005551A1 (en) 2017-05-26
US20200239519A1 (en) 2020-07-30
RU2018122498A (ru) 2019-12-26
JP6873993B2 (ja) 2021-05-19
US11072635B2 (en) 2021-07-27
EP3377474A1 (en) 2018-09-26
IL259429B (en) 2021-12-01
JP2019501123A (ja) 2019-01-17
BR112018010267A2 (pt) 2018-11-27
CN109219596B (zh) 2022-04-19
EP3377474C0 (en) 2023-08-16
RU2761476C2 (ru) 2021-12-08
EP3377474B1 (en) 2023-08-16
KR20180109858A (ko) 2018-10-08

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