MX2017012535A - Compuestos hetorociclicos novedosos y su uso en la prevencion o tratamiento de las infecciones bacterianas. - Google Patents

Compuestos hetorociclicos novedosos y su uso en la prevencion o tratamiento de las infecciones bacterianas.

Info

Publication number
MX2017012535A
MX2017012535A MX2017012535A MX2017012535A MX2017012535A MX 2017012535 A MX2017012535 A MX 2017012535A MX 2017012535 A MX2017012535 A MX 2017012535A MX 2017012535 A MX2017012535 A MX 2017012535A MX 2017012535 A MX2017012535 A MX 2017012535A
Authority
MX
Mexico
Prior art keywords
bacterial infections
preventing
heterocyclic compounds
treating bacterial
novel heterocyclic
Prior art date
Application number
MX2017012535A
Other languages
English (en)
Inventor
Le Strat Fródóric
Chasset Sophie
Chevreuil Francis
Barbion Julien
Brias Julie
Caravano Audrey
Faivre Fabien
Vomscheid Sophie
Simon Christophe
Lecointe Nicolas
Ledoussal Benoí®T
RICHARD Sóbastien
Original Assignee
Mutabilis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP15305473.9A external-priority patent/EP3075733A1/en
Application filed by Mutabilis filed Critical Mutabilis
Publication of MX2017012535A publication Critical patent/MX2017012535A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La presente invención se refiere a compuestos heterocí­clicos, su procedimiento de preparación, composiciones farmacóuticas que comprenden estos compuestos y el uso de las mismas, opcionalmente en combinación con otros agentes antibacterianos y/o compuestos beta-lactámicos, para la prevención o tratamiento de las infecciones bacterianas. La presente invención también se refiere al uso de estos compuestos como inhibidores de íŸ-lactamasa y/o agentes antibacterianos. (ver Fórmula).
MX2017012535A 2015-03-31 2016-03-30 Compuestos hetorociclicos novedosos y su uso en la prevencion o tratamiento de las infecciones bacterianas. MX2017012535A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305473.9A EP3075733A1 (en) 2015-03-31 2015-03-31 Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP16305073 2016-01-26
PCT/EP2016/056847 WO2016156348A1 (en) 2015-03-31 2016-03-30 Novel heterocyclic compounds and their use in preventing or treating bacterial infections

Publications (1)

Publication Number Publication Date
MX2017012535A true MX2017012535A (es) 2018-07-06

Family

ID=55642467

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017012535A MX2017012535A (es) 2015-03-31 2016-03-30 Compuestos hetorociclicos novedosos y su uso en la prevencion o tratamiento de las infecciones bacterianas.

Country Status (13)

Country Link
US (1) US10072006B2 (es)
EP (1) EP3277686B1 (es)
JP (1) JP2018510202A (es)
KR (1) KR20170132301A (es)
CN (1) CN107531708A (es)
AU (1) AU2016239209A1 (es)
BR (1) BR112017020796A2 (es)
CA (1) CA2980085A1 (es)
CL (1) CL2017002451A1 (es)
MX (1) MX2017012535A (es)
RU (1) RU2017133660A (es)
TW (1) TW201643164A (es)
WO (1) WO2016156348A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10183943B2 (en) * 2015-05-07 2019-01-22 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
MX2019003060A (es) * 2016-09-16 2019-07-08 Entasis Therapeutics Ltd Compuestos inhibidores de beta-lactamasa.
EP3300736B1 (en) * 2016-09-30 2021-05-05 Mutabilis Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections
EP3357924A1 (en) * 2017-02-06 2018-08-08 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN109942579B (zh) * 2019-04-18 2021-06-22 成都千禧莱医药科技有限公司 β-内酰胺酶抑制剂含脲双环化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936798B1 (fr) 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
WO2014141132A1 (en) 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Also Published As

Publication number Publication date
CA2980085A1 (en) 2016-10-06
RU2017133660A (ru) 2019-03-28
JP2018510202A (ja) 2018-04-12
WO2016156348A1 (en) 2016-10-06
RU2017133660A3 (es) 2019-08-22
BR112017020796A2 (pt) 2018-06-26
EP3277686A1 (en) 2018-02-07
US20180086761A1 (en) 2018-03-29
US10072006B2 (en) 2018-09-11
EP3277686B1 (en) 2020-07-22
KR20170132301A (ko) 2017-12-01
TW201643164A (zh) 2016-12-16
CL2017002451A1 (es) 2018-04-20
CN107531708A (zh) 2018-01-02
AU2016239209A1 (en) 2017-10-12

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