WO2017218922A8 - Compositions and methods for the treatment of bacterial infections - Google Patents

Compositions and methods for the treatment of bacterial infections Download PDF

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Publication number
WO2017218922A8
WO2017218922A8 PCT/US2017/037924 US2017037924W WO2017218922A8 WO 2017218922 A8 WO2017218922 A8 WO 2017218922A8 US 2017037924 W US2017037924 W US 2017037924W WO 2017218922 A8 WO2017218922 A8 WO 2017218922A8
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
bacterial infections
compositions
methods
gram
Prior art date
Application number
PCT/US2017/037924
Other languages
French (fr)
Other versions
WO2017218922A2 (en
WO2017218922A3 (en
Inventor
James M. Balkovec
Daniel C. BENSEN
Timothy Blizzard
Allen Borchardt
Thomas P. Brady
Zhi-yong CHEN
Quyen-Quyen Thuy Do
Wanlong Jiang
Thanh Lam
Jeffrey B. Locke
Alain Noncovich
Original Assignee
Cidara Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cidara Therapeutics, Inc. filed Critical Cidara Therapeutics, Inc.
Publication of WO2017218922A2 publication Critical patent/WO2017218922A2/en
Publication of WO2017218922A3 publication Critical patent/WO2017218922A3/en
Publication of WO2017218922A8 publication Critical patent/WO2017218922A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.
PCT/US2017/037924 2016-06-17 2017-06-16 Compositions and methods for the treatment of bacterial infections WO2017218922A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662351537P 2016-06-17 2016-06-17
US62/351,537 2016-06-17
US201662397045P 2016-09-20 2016-09-20
US62/397,045 2016-09-20
US201662434268P 2016-12-14 2016-12-14
US62/434,268 2016-12-14

Publications (3)

Publication Number Publication Date
WO2017218922A2 WO2017218922A2 (en) 2017-12-21
WO2017218922A3 WO2017218922A3 (en) 2018-01-25
WO2017218922A8 true WO2017218922A8 (en) 2018-03-01

Family

ID=60664378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/037924 WO2017218922A2 (en) 2016-06-17 2017-06-16 Compositions and methods for the treatment of bacterial infections

Country Status (1)

Country Link
WO (1) WO2017218922A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018187615A1 (en) * 2017-04-05 2018-10-11 Curza Global, Llc Compositions and methods comprising a triaryl polyamine
CN108329225B (en) * 2018-01-24 2021-03-09 北京大学 P-dibenzoyl dimer derivative and synthetic method and application thereof
WO2020014469A1 (en) * 2018-07-11 2020-01-16 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infectons
CN111060606A (en) * 2018-09-29 2020-04-24 湖南九典制药股份有限公司 Method for detecting dirithromycin related substances
WO2020150275A1 (en) * 2019-01-14 2020-07-23 New York University Cyclic peptide dimers
CN111909047B (en) * 2020-08-20 2023-01-31 苏州亚科科技股份有限公司 Preparation process of 2- [ (2-amino-2-oxyethyl) - (carboxymethyl) amino ] acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380356B1 (en) * 1999-12-07 2002-04-30 Advanced Medicine, Inc. Multivalent polymyxin antibiotics
US7807637B2 (en) * 2006-08-11 2010-10-05 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
NZ593892A (en) * 2008-12-23 2013-11-29 Biosource Pharm Inc Antibiotic compositions for the treatment of gram negative infections

Also Published As

Publication number Publication date
WO2017218922A2 (en) 2017-12-21
WO2017218922A3 (en) 2018-01-25

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