WO2020014501A8 - Compositions and methods for the treatment of bacterial infections - Google Patents

Compositions and methods for the treatment of bacterial infections Download PDF

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Publication number
WO2020014501A8
WO2020014501A8 PCT/US2019/041433 US2019041433W WO2020014501A8 WO 2020014501 A8 WO2020014501 A8 WO 2020014501A8 US 2019041433 W US2019041433 W US 2019041433W WO 2020014501 A8 WO2020014501 A8 WO 2020014501A8
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
bacterial infections
compositions
methods
gram
Prior art date
Application number
PCT/US2019/041433
Other languages
French (fr)
Other versions
WO2020014501A1 (en
Inventor
James M. Balkovec
Timothy Blizzard
Allen Borchardt
Thomas P. Brady
Zhi-yong CHEN
Quyen Quyen Thuy DO
Simon DOEHRMANN
Wanlong Jiang
Thanh Lam
Jeffrey B. Locke
Alain Noncovich
Original Assignee
Cidara Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cidara Therapeutics, Inc. filed Critical Cidara Therapeutics, Inc.
Publication of WO2020014501A1 publication Critical patent/WO2020014501A1/en
Publication of WO2020014501A8 publication Critical patent/WO2020014501A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compositions and methods for the treatment of bacterial infections include compounds containing a cyclic heptapeptide. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.
PCT/US2019/041433 2018-07-11 2019-07-11 Compositions and methods for the treatment of bacterial infections WO2020014501A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862696777P 2018-07-11 2018-07-11
US62/696,777 2018-07-11
US201862725123P 2018-08-30 2018-08-30
US62/725,123 2018-08-30
US201862744465P 2018-10-11 2018-10-11
US62/744,465 2018-10-11

Publications (2)

Publication Number Publication Date
WO2020014501A1 WO2020014501A1 (en) 2020-01-16
WO2020014501A8 true WO2020014501A8 (en) 2020-03-12

Family

ID=69143110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/041433 WO2020014501A1 (en) 2018-07-11 2019-07-11 Compositions and methods for the treatment of bacterial infections

Country Status (1)

Country Link
WO (1) WO2020014501A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3810633T3 (en) 2018-06-25 2024-02-09 Spero Therapeutics Inc Compounds
CN113813230B (en) * 2021-10-18 2023-03-14 佛山市南海东方澳龙制药有限公司 Micro emulsion for gamithromycin injection and preparation method thereof
CN114984212B (en) * 2022-05-13 2023-12-19 温州医科大学 Nanometer bactericidal material, compound, polymer and application of nanometer bactericidal material, compound and polymer in preparation of nanometer bactericide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807637B2 (en) * 2006-08-11 2010-10-05 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
WO2018006063A1 (en) * 2016-07-01 2018-01-04 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections

Also Published As

Publication number Publication date
WO2020014501A1 (en) 2020-01-16

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