EA033311B1 - Производные бензоксаборола в качестве антибактериальных средств - Google Patents

Производные бензоксаборола в качестве антибактериальных средств

Info

Publication number
EA033311B1
EA033311B1 EA201791850A EA201791850A EA033311B1 EA 033311 B1 EA033311 B1 EA 033311B1 EA 201791850 A EA201791850 A EA 201791850A EA 201791850 A EA201791850 A EA 201791850A EA 033311 B1 EA033311 B1 EA 033311B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibacterial agents
compounds
benzoxaborole derivatives
benzoxaborole
derivatives
Prior art date
Application number
EA201791850A
Other languages
English (en)
Other versions
EA201791850A1 (ru
Inventor
Винсент С. Эрнандес
Чарльз Дин
Джейкоб Дж. Плэттнер
Майкл Ричард Кевин Элли
Фернандо Рок
Суоминг Чжанг
Эрик Исом
Сяньфэн Ли
Дин Чжоу
Original Assignee
Анакор Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Анакор Фармасьютикалс, Инк. filed Critical Анакор Фармасьютикалс, Инк.
Publication of EA201791850A1 publication Critical patent/EA201791850A1/ru
Publication of EA033311B1 publication Critical patent/EA033311B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к соединениям, имеющим структуру (I), к композиции, комбинации и фармацевтическому составу, содержащим указанные соединения, к способу in vitro с использованием указанных соединений, а также к их применению для лечения и/или предотвращения бактериальных инфекций:
EA201791850A 2010-09-07 2011-09-07 Производные бензоксаборола в качестве антибактериальных средств EA033311B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38059610P 2010-09-07 2010-09-07

Publications (2)

Publication Number Publication Date
EA201791850A1 EA201791850A1 (ru) 2018-01-31
EA033311B1 true EA033311B1 (ru) 2019-09-30

Family

ID=44653589

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201390274A EA028743B1 (ru) 2010-09-07 2011-09-07 Производные бензоксаборолов в качестве антибактериальных средств
EA201791850A EA033311B1 (ru) 2010-09-07 2011-09-07 Производные бензоксаборола в качестве антибактериальных средств

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201390274A EA028743B1 (ru) 2010-09-07 2011-09-07 Производные бензоксаборолов в качестве антибактериальных средств

Country Status (25)

Country Link
US (4) US8703742B2 (ru)
EP (2) EP3251678B1 (ru)
JP (4) JP5952280B2 (ru)
KR (2) KR101949423B1 (ru)
CN (2) CN103140228A (ru)
AU (1) AU2011299243C1 (ru)
BR (1) BR112013005426B1 (ru)
CA (1) CA2810021C (ru)
CY (1) CY1124728T1 (ru)
DK (2) DK3251678T3 (ru)
EA (2) EA028743B1 (ru)
ES (2) ES2898695T3 (ru)
HK (1) HK1247841A1 (ru)
HR (1) HRP20211762T1 (ru)
HU (1) HUE059033T2 (ru)
IL (2) IL225000A (ru)
LT (1) LT3251678T (ru)
MX (1) MX338209B (ru)
PL (1) PL3251678T3 (ru)
PT (1) PT3251678T (ru)
RS (1) RS62548B1 (ru)
SG (2) SG10201507032YA (ru)
SI (1) SI3251678T1 (ru)
WO (1) WO2012033858A2 (ru)
ZA (1) ZA201301598B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008571A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
WO2011019618A1 (en) * 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
CN103140228A (zh) * 2010-09-07 2013-06-05 阿纳科制药公司 苯并氧杂硼杂环戊二烯衍生物用于治疗细菌感染
US8530452B2 (en) 2011-12-22 2013-09-10 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
JP5927686B1 (ja) 2013-01-30 2016-06-01 アグロフレッシュ インコーポレイテッド 食肉、植物または植物の一部分に対する揮発性抗菌剤としてのベンゾオキサボロールの使用
US9598443B2 (en) 2013-02-01 2017-03-21 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
KR102093783B1 (ko) * 2013-08-09 2020-03-26 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 트리시클릭 벤족사보롤 화합물 및 이의 용도
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
KR20170024068A (ko) 2014-07-01 2017-03-06 다이이찌 산쿄 가부시키가이샤 항박테리아제로서의 삼환식 벤즈옥사보롤
MA41494B1 (fr) * 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US10961261B2 (en) 2017-03-01 2021-03-30 Anacor Pharmaceuticals, Inc. Oxaborole analogs and uses thereof
CN111655035A (zh) 2017-11-30 2020-09-11 博瑞金股份有限公司 苯并氧杂硼杂环戊烯化合物和其制剂
CN108727176B (zh) * 2018-07-26 2021-05-18 荆楚理工学院 一种制备5-卤-2,3-二羟基苯甲醛的方法
WO2020041200A1 (en) 2018-08-18 2020-02-27 Boragen Inc. Solid forms of substituted benzoxaborole and compositions thereof
US20220275007A1 (en) * 2019-07-30 2022-09-01 Boragen, Inc. Flow reaction process for manufacture of boron-containing agrochemicals
CN110664756B (zh) * 2019-10-09 2020-11-17 吉林大学 一种小儿外伤喷雾剂及其制备方法
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
WO2023246842A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
WO2023246841A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
CN115572218B (zh) * 2022-08-29 2024-04-16 江阴勒森生物科技有限公司 一种2-溴-3-羟基苯甲醛及其相关化学发光底物中间体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157726A1 (en) * 2007-06-20 2008-12-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
US3686398A (en) 1970-07-20 1972-08-22 Chevron Res 10,9-boroxarophenanthrene as fungicides
GB1396904A (en) 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US4602011A (en) 1975-10-24 1986-07-22 Chapman Chemical Company Antimicrobial compositions and methods of using same
US4766113A (en) 1975-10-24 1988-08-23 Chapman Chemical Company Antimicrobial compositions and methods of using same
US4716035A (en) 1985-05-24 1987-12-29 The Procter & Gamble Company Oral compositions and methods for treating gingivitis
US5962498A (en) 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4894220A (en) 1987-01-30 1990-01-16 Colgate-Palmolive Company Antibacterial antiplaque oral composition
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5274792A (en) 1989-08-19 1993-12-28 Fujitsu Limited Information processing apparatus with parallel instruction decoding
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5348947A (en) 1993-05-07 1994-09-20 American Cyanamid Company Diarylboron ester and thioester fungicidal agents
US5348948A (en) 1993-05-07 1994-09-20 American Cyanamid Company 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal
US5594151A (en) 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
GB9500856D0 (en) 1995-01-17 1995-03-08 Zeneca Ltd Composition and use
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
JP4373497B2 (ja) 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド 置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
US5831046A (en) 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
AU4486097A (en) 1996-09-19 1998-04-14 Board Of Trustees Of The Leland Stanford Junior University Dna adenine methyltransferases and uses thereof
WO1998024753A1 (fr) 1996-12-02 1998-06-11 Chisso Corporation Derives de nitro-alcool actifs optiquement, derives d'amino-alcool actifs optiquement et leur procede de preparation
US6221640B1 (en) 1997-05-14 2001-04-24 Cubist Pharmaceuticals, Inc. Enterococcal aminoacyl-trna synthetase proteins, nucleic acids and strains comprising same
DE19829947A1 (de) 1998-07-04 2000-01-05 Bayer Ag Elektrolumineszierende Anordnungen mit Bor-Chelaten
CN1335836A (zh) 1998-11-06 2002-02-13 巴斯福股份公司 三环吡唑衍生物
US6462036B1 (en) 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
EP1155698A4 (en) 1999-01-29 2003-01-15 Nitto Kasei Co Ltd ORGANOBORAL COMPOUNDS HAVING COCCIDIOSTAT ACTIVITY
WO2000075142A2 (en) 1999-05-25 2000-12-14 The Penn State Research Foundation Dna methyltransferase inhibitors
EP1210449B1 (en) 1999-08-25 2006-12-27 Ambergen, Inc. Methods for the detection, analysis and isolation of nascent proteins
US6306628B1 (en) 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
WO2001025226A1 (en) 1999-10-05 2001-04-12 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
WO2001049303A1 (en) 2000-01-06 2001-07-12 Marantech Holding, Llc Multivalent electron active compositions and methods of making and using same
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
JP2004506417A (ja) 2000-07-14 2004-03-04 ザイコス　インク． α−ＭＳＨ関連化合物および使用方法
AU3940702A (en) 2000-11-30 2002-06-11 Penn State Res Found Dna methyl transferase inhibitors
DE10110051C2 (de) 2001-03-02 2003-07-03 Clariant Gmbh Verfahren zur Herstellung von Boron- und Borinsäuren
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
GB0117645D0 (en) 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
DE10143979A1 (de) 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
US7217701B2 (en) 2001-10-11 2007-05-15 Katsuhiko Mikoshiba Intracellular calcium concentration increase inhibitors
AU2003205089B2 (en) 2002-01-10 2007-01-25 The Pennsylvania State Research Foundation Methods for the preparation of alkyl diaryl borinates and complexed diarylborinic acids
AU2003248921A1 (en) 2002-07-09 2004-01-23 Point Therapeutics, Inc. Boroproline compound combination therapy
JP2006508161A (ja) 2002-12-02 2006-03-09 ソルヴィーアス　アクチェンゲゼルシャフト 炭素−ヘテロ原子二重結合の接触水素化
EP1980564A1 (en) 2002-12-18 2008-10-15 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
US7390806B2 (en) 2002-12-18 2008-06-24 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
US20050125852A1 (en) 2003-05-09 2005-06-09 Sugen, Inc. Novel kinases
US7465836B2 (en) 2003-06-16 2008-12-16 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
EP1755661B1 (en) 2004-05-12 2014-03-12 The Brigham And Women's Hospital, Inc. Gelsolin for use in treating infections
AR049915A1 (es) 2004-06-14 2006-09-13 Anacor Pharmaceuticals Inc Compuestos con contenido de boro y metodos de uso de los mismos
WO2006062731A1 (en) 2004-11-19 2006-06-15 University Of North Texas Health Science Center At Fort Worth Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye
GB0501944D0 (en) 2005-01-31 2005-03-09 Univ Cambridge Tech Compounds for use in chemical detection and/or quantitation
ES2872962T3 (es) * 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronoftalidas para uso terapéutico
JP5084717B2 (ja) 2005-03-08 2012-11-28 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ キラル・ビスオキサゾリン触媒
US20060222671A1 (en) 2005-03-30 2006-10-05 Astion Development A/S Dermatological compositions and salts for the treatment of dermatological diseases
US20080234229A1 (en) 2005-08-18 2008-09-25 Auspex Pharmaceuticals, Inc. Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders
CN106008571A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
KR101622870B1 (ko) * 2006-02-16 2016-05-19 아나코르 파마슈티칼스 인코포레이티드 항염증제로서 보론함유 소분자
WO2007131072A2 (en) * 2006-05-02 2007-11-15 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
KR20090029797A (ko) 2006-06-12 2009-03-23 아나코르 파마슈티칼스 인코포레이티드 치주질환의 치료를 위한 화합물
US20070286822A1 (en) 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
WO2009111676A2 (en) 2008-03-06 2009-09-11 Anacor Pharmaceuticals, Inc Boron-containing small molecules as anti-inflammatory agents
MX2010009765A (es) 2008-03-06 2013-07-12 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
EP2285384A4 (en) 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
WO2010028005A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045505A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc Boron-containing small molecules as anti-protozoal agents
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
PE20120052A1 (es) 2008-12-17 2012-02-13 Anacor Pharmaceuticals Inc Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c][1,2]-oxaborol-1-ol
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
CN103140228A (zh) 2010-09-07 2013-06-05 阿纳科制药公司 苯并氧杂硼杂环戊二烯衍生物用于治疗细菌感染

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157726A1 (en) * 2007-06-20 2008-12-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules

Also Published As

Publication number Publication date
PL3251678T3 (pl) 2022-01-10
AU2011299243C1 (en) 2016-06-02
JP2018058836A (ja) 2018-04-12
CN103140228A (zh) 2013-06-05
PT3251678T (pt) 2021-11-22
US9751898B2 (en) 2017-09-05
KR20140093598A (ko) 2014-07-28
LT3251678T (lt) 2021-12-10
EP3251678A1 (en) 2017-12-06
EP2613788B1 (en) 2017-06-21
JP2013541514A (ja) 2013-11-14
US8703742B2 (en) 2014-04-22
HK1247841A1 (zh) 2018-10-05
AU2011299243A1 (en) 2013-03-28
JP6491294B2 (ja) 2019-03-27
ZA201301598B (en) 2021-08-25
SG187969A1 (en) 2013-04-30
EP2613788A2 (en) 2013-07-17
SG10201507032YA (en) 2015-10-29
EP3251678B1 (en) 2021-10-20
RS62548B1 (sr) 2021-12-31
IL244556B (en) 2020-07-30
CA2810021A1 (en) 2012-03-15
KR101949423B1 (ko) 2019-02-18
US20140315860A1 (en) 2014-10-23
ES2635333T3 (es) 2017-10-03
JP2019112431A (ja) 2019-07-11
JP5952280B2 (ja) 2016-07-13
IL225000A (en) 2016-03-31
BR112013005426A2 (pt) 2016-06-07
US20190345173A1 (en) 2019-11-14
SI3251678T1 (sl) 2022-01-31
EA201390274A1 (ru) 2013-08-30
IL244556A0 (en) 2016-04-21
MX2013002651A (es) 2013-04-19
ES2898695T3 (es) 2022-03-08
US20120115813A1 (en) 2012-05-10
EA201791850A1 (ru) 2018-01-31
EA028743B1 (ru) 2017-12-29
WO2012033858A2 (en) 2012-03-15
CN108610356A (zh) 2018-10-02
HUE059033T2 (hu) 2022-10-28
DK2613788T3 (en) 2017-08-07
WO2012033858A3 (en) 2012-05-10
BR112013005426B1 (pt) 2021-08-24
KR102152901B1 (ko) 2020-09-07
HRP20211762T1 (hr) 2022-02-18
US11008345B2 (en) 2021-05-18
AU2011299243B2 (en) 2015-09-17
JP2016199558A (ja) 2016-12-01
CY1124728T1 (el) 2022-07-22
CN108610356B (zh) 2021-02-26
DK3251678T3 (da) 2021-11-22
MX338209B (es) 2016-04-07
ES2898695T8 (es) 2022-03-16
KR20190018549A (ko) 2019-02-22
US20170355719A1 (en) 2017-12-14
CA2810021C (en) 2018-05-29

Similar Documents

Publication Publication Date Title
EA033311B1 (ru) Производные бензоксаборола в качестве антибактериальных средств
AU2015205914B2 (en) 1,6- diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections
GEP20156370B (en) Fluoro-pyridinone derivatives useful as antibacterial agents
MX349827B (es) Compuestos que contienen nitrogeno y su uso.
MX340533B (es) Derivados de 1,6- diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas.
WO2010090860A3 (en) Methods and compositions for treating bacterial infection
UY31673A1 (es) "derivados heterocíclicos de urea y métodos de uso de los mismos-211"
MX2009005603A (es) Compuestos de urea policiclicos antibacterianos.
IL221940A (en) Small anti-infective compounds, pharmaceutical preparations containing them and their use in the preparation of drugs for the treatment of bacterial infections
PH12015501609A1 (en) Phenicol antibacterials
IL211120A (en) Compound, tetracycline converted at position 7c with fluorine, a pharmaceutical preparation containing it and its use in the preparation of drugs for the treatment of bacteria-caused infection
WO2011160024A3 (en) Compounds useful as antiviral agents, compositions, and methods of use
TW200942530A (en) Pyridine compounds
GEP20156346B (en) Imidazole derivatives as pde10a enzyme inhibitors
CL2013001482A1 (es) Compuestos derivados de 3-metil-7-oxo-4-tia-1-aza-biciclo[3.2.0]heptano para utilizarse en la inhibicion de beta-lactamasas producidas por bacterias y restaurar/potenciar la actividad de antibioticos; y composicion farmaceutica que los comprende.
IN2012DN01414A (ru)
MX2009006325A (es) Compuestos de heteroaril-heteroarilo como inhibidores de cdk para el tratamiento de cancer, inflamacion e infecciones virales.
WO2015066302A3 (en) Compositions, methods of use, and methods of treatment
HK1137947A1 (en) Compositions and methods for treating, reducing, ameliorating, or preventing infections caused by antibacterial drug-resistant bacteria
IL218388A (en) Hydroxyphenyl compounds, pharmaceuticals containing them, their use in the treatment of antimicrobial infections, their preparation and intermediates in the process
IN2015DN02109A (ru)
PH12015500518A1 (en) Tricyclic tetrahydroquinoline antibacterial agents
MX2012004282A (es) Composiciones farmaceuticas.
SG178936A1 (en) Compositions and methods for treating bacterial infections using ceftaroline
MX2015014657A (es) Nuevos agentes antibacterianos de fenicol.