PE20001485A1 - Derivados de la camptotecina que tienen actividad antitumoral - Google Patents

Derivados de la camptotecina que tienen actividad antitumoral

Info

Publication number
PE20001485A1
PE20001485A1 PE2000000206A PE0002062000A PE20001485A1 PE 20001485 A1 PE20001485 A1 PE 20001485A1 PE 2000000206 A PE2000000206 A PE 2000000206A PE 0002062000 A PE0002062000 A PE 0002062000A PE 20001485 A1 PE20001485 A1 PE 20001485A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
alcoxy
heterocycle
alkenyl
Prior art date
Application number
PE2000000206A
Other languages
English (en)
Inventor
Paolo Carminati
Franco Zunino
Sergio Penco
Lucio Merlini
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of PE20001485A1 publication Critical patent/PE20001485A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CAMPTOTECINA DE FORMULA I, DONDE R1 ES C(R5)=N-O(n)R4; R4 ES H, ALQUILO C1-C8, ALQUENILO C1-C8, CICLOALQUILO C3-C10, CICLOALQUILO C3-C10-ALQUILO C1-C8, ARILO C6-C14, HETEROCICLO, HETEROCICLO-ALQUILO C1-C8, ENTRE OTROS; R4 ES AROILO C6-C10, ARILSULFONILO C6-C10 OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH, ALQUILO C1-C8, ALCOXI, FENILO, CIANO, NITRO, NR10R11; R10 Y R11 SON H, ALQUILO C1-C8; R4 ES POLIAMINOALQUILO, GLICOSILO; n ES 0-1; R5 ES H, ALQUILO C1-C8, ALQUENILO C1-C8, CICLOALQUILO C3-C10, CICLOALQUILO C3-C10-ALQUILO C1-C8, ENTRE OTROS; R2 Y R3 SON H, OH, ALCOXI C1-C8, CUANDO R5, R2 Y R3 SON H; n ES 1, ENTONCES R4 NO ES H. SON COMPUESTOS PREFERIDOS 7-METOXIIMINOMETILCAMPTOTECINA, 7-METOXIIMINOMETILO-10-HIDROXICAMPTOTECINA, 7-[N-(4-AMINOBUTILO)-2-AMINOETOXI]IMINOMETILCAMPTOTECINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION, A COMPUESTOS INTERMEDIOS Y A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE ADEMAS UN AGENTE ANTITUMORAL. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE TUMORES, INFECCIONES VIRALES, ACTIVIDAD ANTIPLASMODIO FALCIPARUM
PE2000000206A 1999-03-09 2000-03-08 Derivados de la camptotecina que tienen actividad antitumoral PE20001485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity

Publications (1)

Publication Number Publication Date
PE20001485A1 true PE20001485A1 (es) 2000-12-07

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000206A PE20001485A1 (es) 1999-03-09 2000-03-08 Derivados de la camptotecina que tienen actividad antitumoral

Country Status (39)

Country Link
US (2) US6242457B1 (es)
EP (1) EP1044977B1 (es)
JP (1) JP4610743B2 (es)
KR (1) KR100702085B1 (es)
CN (1) CN1139592C (es)
AR (1) AR022860A1 (es)
AT (1) ATE216998T1 (es)
AU (1) AU774174B2 (es)
BG (1) BG65032B1 (es)
BR (1) BR0008840B1 (es)
CA (1) CA2362760C (es)
CO (1) CO5180590A1 (es)
CZ (1) CZ304465B6 (es)
DE (1) DE69901379T2 (es)
DK (1) DK1044977T3 (es)
EA (1) EA003605B1 (es)
EE (1) EE04679B1 (es)
EG (1) EG23999A (es)
ES (1) ES2175919T3 (es)
HK (1) HK1031222A1 (es)
HR (1) HRP20010667B1 (es)
HU (1) HU229506B1 (es)
IL (2) IL144958A0 (es)
IS (1) IS2003B (es)
ME (2) ME00017B (es)
MX (1) MXPA01009081A (es)
NO (1) NO328363B1 (es)
NZ (1) NZ513393A (es)
PE (1) PE20001485A1 (es)
PL (1) PL222208B1 (es)
PT (1) PT1044977E (es)
RS (1) RS50405B (es)
SI (1) SI1044977T1 (es)
SK (1) SK287561B6 (es)
TN (1) TNSN00045A1 (es)
TR (1) TR200102603T2 (es)
TW (1) TWI272272B (es)
WO (1) WO2000053607A1 (es)
ZA (1) ZA200107408B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010113642A (ko) 1999-01-13 2001-12-28 추후기재 약물의 효능을 증대시키기 위한 조성물 및 증대 방법
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN101480395A (zh) * 2004-03-26 2009-07-15 诺瓦提斯公司 喜树碱衍生物以固定给药方案治疗增生性疾病的用途
WO2005113018A2 (en) 2004-04-27 2005-12-01 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
MX2007007212A (es) * 2004-12-15 2007-11-07 Novartis Ag Combinaciones de agentes terapeuticos para el tratamiento del cancer.
US7799921B2 (en) * 2004-12-21 2010-09-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Stereoselective process and crystalline forms of a camptothecin
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
RU2435586C2 (ru) 2005-07-14 2011-12-10 Веллстат Байолоджикс Корпорейшн Лечение рака с применением вирусов, фторпиримидинов и камптотецинов
CN101287474B (zh) * 2005-07-27 2014-08-20 阿尔卡米亚肿瘤学股份有限公司 使用乙酰透明质酸的治疗方案
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
AU2006277960A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Formulations for 7-(T-butoxy)iminomethyl camptothecin
EA013877B1 (ru) * 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
WO2007071603A1 (en) 2005-12-21 2007-06-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treatment of drug-resistant tumors
EP1989212B1 (en) * 2006-02-17 2013-06-19 Cascade Prodrug Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
US20100166843A1 (en) * 2007-02-01 2010-07-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
CA2694389C (en) * 2007-08-01 2016-01-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Treatment of pediatric tumors
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
CN108135917B (zh) 2015-09-25 2021-07-09 Zy医疗 基于包含多糖-维生素缀合物的颗粒的药物制剂

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US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
CA2123321C (en) * 1991-11-15 2003-09-30 Randall Keith Johnson Combination chemotherapy
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
ES2214634T3 (es) * 1996-08-19 2004-09-16 Bionumerik Pharmaceuticals, Inc. Derivados muy lipofilos de la camptotecina.

Also Published As

Publication number Publication date
EA200100954A1 (ru) 2002-04-25
CA2362760A1 (en) 2000-09-14
CZ20013077A3 (cs) 2002-01-16
AU774174B2 (en) 2004-06-17
CO5180590A1 (es) 2002-07-30
HU229506B1 (en) 2014-01-28
ATE216998T1 (de) 2002-05-15
US20010008939A1 (en) 2001-07-19
IL144958A (en) 2009-08-03
NZ513393A (en) 2003-04-29
CN1343209A (zh) 2002-04-03
ZA200107408B (en) 2002-05-29
JP2002539128A (ja) 2002-11-19
PL355094A1 (en) 2004-03-22
EG23999A (en) 2008-03-19
MXPA01009081A (es) 2002-08-30
HK1031222A1 (en) 2001-06-08
US6589939B2 (en) 2003-07-08
HUP0200210A2 (hu) 2002-05-29
HRP20010667A2 (en) 2002-08-31
SK287561B6 (sk) 2011-02-04
TR200102603T2 (tr) 2002-01-21
CN1139592C (zh) 2004-02-25
BG65032B1 (bg) 2006-12-29
SK11642001A3 (sk) 2002-01-07
NO20014128L (no) 2001-08-24
CA2362760C (en) 2009-08-18
YU64301A (sh) 2005-07-19
HUP0200210A3 (en) 2004-03-29
EE200100466A (et) 2002-12-16
DE69901379D1 (de) 2002-06-06
SI1044977T1 (en) 2002-08-31
BR0008840B1 (pt) 2011-12-27
PL222208B1 (pl) 2016-07-29
RS50405B (sr) 2009-12-31
AU3160400A (en) 2000-09-28
AR022860A1 (es) 2002-09-04
DE69901379T2 (de) 2002-11-07
IS6031A (is) 2001-07-31
EA003605B1 (ru) 2003-06-26
BG105810A (en) 2002-06-28
CZ304465B6 (cs) 2014-05-21
EP1044977B1 (en) 2002-05-02
MEP4008A (xx) 2010-02-10
KR100702085B1 (ko) 2007-04-02
IS2003B (is) 2005-04-15
HRP20010667B1 (en) 2003-06-30
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
EE04679B1 (et) 2006-08-15
NO20014128D0 (no) 2001-08-24
WO2000053607A1 (en) 2000-09-14
TWI272272B (en) 2007-02-01
DK1044977T3 (da) 2002-07-08
IL144958A0 (en) 2002-06-30
BR0008840A (pt) 2002-01-08
KR20010102519A (ko) 2001-11-15
JP4610743B2 (ja) 2011-01-12
EP1044977A1 (en) 2000-10-18
ME00017B (me) 2010-06-10
TNSN00045A1 (fr) 2005-11-10
ES2175919T3 (es) 2002-11-16
US6242457B1 (en) 2001-06-05

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