ITRM20020306A1 - Esteri in posizione 20 di camptotecine. - Google Patents

Esteri in posizione 20 di camptotecine.

Info

Publication number
ITRM20020306A1
ITRM20020306A1 IT2002RM000306A ITRM20020306A ITRM20020306A1 IT RM20020306 A1 ITRM20020306 A1 IT RM20020306A1 IT 2002RM000306 A IT2002RM000306 A IT 2002RM000306A IT RM20020306 A ITRM20020306 A IT RM20020306A IT RM20020306 A1 ITRM20020306 A1 IT RM20020306A1
Authority
IT
Italy
Prior art keywords
camptotecine
esters
Prior art date
Application number
IT2002RM000306A
Other languages
English (en)
Inventor
Maria Ornella Tinti
Mauro Marzi
Loredana Vesci
Claudio Pisano
Franco Zunino
Domenico Aloatti
Original Assignee
Sigma Tau Ind Farmaceuti
Istituto Naz Per Lo Studio E C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Istituto Naz Per Lo Studio E C filed Critical Sigma Tau Ind Farmaceuti
Priority to IT2002RM000306A priority Critical patent/ITRM20020306A1/it
Publication of ITRM20020306A0 publication Critical patent/ITRM20020306A0/it
Priority to TW092114165A priority patent/TWI331151B/zh
Priority to AT03730481T priority patent/ATE439362T1/de
Priority to DE60328777T priority patent/DE60328777D1/de
Priority to KR1020047016881A priority patent/KR101000963B1/ko
Priority to AU2003241161A priority patent/AU2003241161C1/en
Priority to PL03374009A priority patent/PL374009A1/xx
Priority to ES03730481T priority patent/ES2331569T3/es
Priority to SI200332302T priority patent/SI2112154T1/sl
Priority to CNB038125447A priority patent/CN100376583C/zh
Priority to PCT/IT2003/000329 priority patent/WO2003101996A2/en
Priority to DK03730481T priority patent/DK1509529T3/da
Priority to PT91627372T priority patent/PT2112154E/pt
Priority to ES09162737T priority patent/ES2432379T3/es
Priority to EP03730481A priority patent/EP1509529B1/en
Priority to JP2004509687A priority patent/JP4593270B2/ja
Priority to CA2487252A priority patent/CA2487252C/en
Priority to MXPA04011681A priority patent/MXPA04011681A/es
Priority to DK09162737.2T priority patent/DK2112154T3/da
Priority to HK05111354.2A priority patent/HK1079206B/xx
Priority to US10/512,094 priority patent/US7452900B2/en
Priority to SI200331685T priority patent/SI1509529T1/sl
Priority to EP09162737.2A priority patent/EP2112154B1/en
Priority to PT03730481T priority patent/PT1509529E/pt
Priority to PE2003000528A priority patent/PE20040533A1/es
Priority to ARP030101916A priority patent/AR040140A1/es
Publication of ITRM20020306A1 publication Critical patent/ITRM20020306A1/it
Priority to US11/783,495 priority patent/US7498340B2/en
Priority to CY20091101143T priority patent/CY1109581T1/el
Priority to CY20131100832T priority patent/CY1114692T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
IT2002RM000306A 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine. ITRM20020306A1 (it)

Priority Applications (29)

Application Number Priority Date Filing Date Title
IT2002RM000306A ITRM20020306A1 (it) 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine.
TW092114165A TWI331151B (en) 2002-05-31 2003-05-26 Esters in position 20 of camptothecins
PT03730481T PT1509529E (pt) 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas
EP03730481A EP1509529B1 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
JP2004509687A JP4593270B2 (ja) 2002-05-31 2003-05-28 カンプトテシンの２０位のエステル
KR1020047016881A KR101000963B1 (ko) 2002-05-31 2003-05-28 캄토테신의 20 번 위치의 에스테르
AU2003241161A AU2003241161C1 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
PL03374009A PL374009A1 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
ES03730481T ES2331569T3 (es) 2002-05-31 2003-05-28 Esteres de camptotecinas en la posicion 20.
SI200332302T SI2112154T1 (sl) 2002-05-31 2003-05-28 Estri v poloĹľaju 20 kamptotecinov
CNB038125447A CN100376583C (zh) 2002-05-31 2003-05-28 喜树碱20位酯
PCT/IT2003/000329 WO2003101996A2 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
DK03730481T DK1509529T3 (da) 2002-05-31 2003-05-28 Estere på camptotheciners position 20
PT91627372T PT2112154E (pt) 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas
ES09162737T ES2432379T3 (es) 2002-05-31 2003-05-28 Ésteres en posición 20 de camptotecinas
AT03730481T ATE439362T1 (de) 2002-05-31 2003-05-28 Ester in position 20 von camptothecinen
DE60328777T DE60328777D1 (en) 2002-05-31 2003-05-28 Ester in position 20 von camptothecinen
CA2487252A CA2487252C (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
MXPA04011681A MXPA04011681A (es) 2002-05-31 2003-05-28 Esteres en la posicion 20 de camptotecinas.
DK09162737.2T DK2112154T3 (da) 2002-05-31 2003-05-28 Estre i position 20 af camptothecin
HK05111354.2A HK1079206B (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
US10/512,094 US7452900B2 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
SI200331685T SI1509529T1 (sl) 2002-05-31 2003-05-28 Estri na poziciji 20 kamptotecina
EP09162737.2A EP2112154B1 (en) 2002-05-31 2003-05-28 Esters in position 20 of camptothecins
ARP030101916A AR040140A1 (es) 2002-05-31 2003-05-30 Derivados de esteres de camptotecina en la posicion 20
PE2003000528A PE20040533A1 (es) 2002-05-31 2003-05-30 Esteres en posicion 20 de las camptotecinas
US11/783,495 US7498340B2 (en) 2002-05-31 2007-04-10 Esters in position 20 of camptothecins
CY20091101143T CY1109581T1 (el) 2002-05-31 2009-11-04 Εστερες στη θεση 20 των καμπτοθεκινων
CY20131100832T CY1114692T1 (el) 2002-05-31 2013-09-24 Εστερες στη θεση 20 των καμπτοθεκινων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000306A ITRM20020306A1 (it) 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine.

Publications (2)

Publication Number Publication Date
ITRM20020306A0 ITRM20020306A0 (it) 2002-05-31
ITRM20020306A1 true ITRM20020306A1 (it) 2003-12-01

Family

ID=11456339

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002RM000306A ITRM20020306A1 (it) 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine.

Country Status (21)

Country Link
US (2) US7452900B2 (it)
EP (2) EP1509529B1 (it)
JP (1) JP4593270B2 (it)
KR (1) KR101000963B1 (it)
CN (1) CN100376583C (it)
AR (1) AR040140A1 (it)
AT (1) ATE439362T1 (it)
AU (1) AU2003241161C1 (it)
CA (1) CA2487252C (it)
CY (2) CY1109581T1 (it)
DE (1) DE60328777D1 (it)
DK (2) DK2112154T3 (it)
ES (2) ES2432379T3 (it)
IT (1) ITRM20020306A1 (it)
MX (1) MXPA04011681A (it)
PE (1) PE20040533A1 (it)
PL (1) PL374009A1 (it)
PT (2) PT1509529E (it)
SI (2) SI2112154T1 (it)
TW (1) TWI331151B (it)
WO (1) WO2003101996A2 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
KR20070008710A (ko) 2004-04-27 2007-01-17 웰스테트 바이올로직스 코포레이션 바이러스 및 캄토테신을 이용한 암치료 방법
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
JP5190958B2 (ja) 2005-07-14 2013-04-24 ウェルスタット バイオロジクス コーポレイション ウイルス、フルオロピリミジンおよびカンプトテシンを使用した癌の処置
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
US9962452B2 (en) * 2013-02-04 2018-05-08 Zhuhai Beihai Biotech Co., Ltd. Soluble complexes of drug analogs and albumin
WO2015200837A1 (en) 2014-06-27 2015-12-30 Fl Therapeutics Llc Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en) 2014-10-24 2016-04-28 Fl Therapeutics Llc 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
KR20180058759A (ko) 2015-09-25 2018-06-01 제트와이 테라퓨틱스 인코포레이티드 폴리사카라이드-비타민 접합체를 포함하는 미립자를 기재로 하는 약물 제제
CN106279286B (zh) * 2016-08-12 2018-11-30 华中科技大学 一种喜树碱膦酸酯类化合物、其制备方法及应用
CN110577551A (zh) * 2018-06-08 2019-12-17 遵义医学院 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用
CA3146510A1 (en) 2019-07-11 2021-01-14 Sun Pharma Advanced Research Company Ltd. Camptothecin derivatives with a disulfide moiety and a piperazine moiety
CN116514829A (zh) * 2020-08-21 2023-08-01 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP3186166B2 (ja) * 1992-02-10 2001-07-11 ロンザ リミテッド サリチロイル−カルニチンおよびその製造方法
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
JP3751025B2 (ja) 1995-12-15 2006-03-01 ザ デクスター コーポレイション 研摩性不織繊維ウェブ材料及びその製造方法
AU764807B2 (en) 1998-07-30 2003-08-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of L-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
DE69901379T2 (de) * 1999-03-09 2002-11-07 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori, Mailand/Milano Camptothecin-Derivate mit Antitumor-Wirkung
DE19916945C1 (de) 1999-04-15 2000-10-05 Clariant Gmbh Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6288072B1 (en) 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6629995B1 (en) 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates

Also Published As

Publication number Publication date
PE20040533A1 (es) 2004-08-26
CY1114692T1 (el) 2016-10-05
US20070213353A1 (en) 2007-09-13
US7498340B2 (en) 2009-03-03
EP2112154B1 (en) 2013-07-24
WO2003101996A8 (en) 2004-04-29
JP2005529935A (ja) 2005-10-06
CA2487252C (en) 2010-08-10
SI1509529T1 (sl) 2009-12-31
EP1509529A2 (en) 2005-03-02
WO2003101996A3 (en) 2004-01-29
MXPA04011681A (es) 2005-03-31
US20050256148A1 (en) 2005-11-17
HK1079206A1 (en) 2006-03-31
EP1509529B1 (en) 2009-08-12
WO2003101996A2 (en) 2003-12-11
PL374009A1 (en) 2005-09-19
TWI331151B (en) 2010-10-01
ATE439362T1 (de) 2009-08-15
ES2331569T3 (es) 2010-01-08
CY1109581T1 (el) 2014-08-13
AU2003241161B2 (en) 2009-10-22
SI2112154T1 (sl) 2013-12-31
ES2432379T3 (es) 2013-12-03
PT1509529E (pt) 2009-11-13
AU2003241161C1 (en) 2010-03-04
KR101000963B1 (ko) 2010-12-13
DE60328777D1 (en) 2009-09-24
PT2112154E (pt) 2013-10-02
CN100376583C (zh) 2008-03-26
CN1656101A (zh) 2005-08-17
KR20050036910A (ko) 2005-04-20
CA2487252A1 (en) 2003-12-11
DK1509529T3 (da) 2009-12-14
US7452900B2 (en) 2008-11-18
AR040140A1 (es) 2005-03-16
AU2003241161A1 (en) 2003-12-19
JP4593270B2 (ja) 2010-12-08
ITRM20020306A0 (it) 2002-05-31
DK2112154T3 (da) 2013-10-21
EP2112154A1 (en) 2009-10-28
TW200403246A (en) 2004-03-01

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